How to Save Money on Entresto in 2026: Coupons, Discounts, and Patient Assistance

Entresto Is Expensive — But You Don't Have to Pay Full Price

If you've seen the price tag on Entresto, you know it's not cheap. Brand-name Entresto can cost $600 to $700 per month without insurance — that's over $7,000 a year for a medication you need to take every day to manage your heart failure.

But here's the good news: 2026 is the best year yet for Entresto savings. Between generic versions, Medicare price negotiation, manufacturer discount programs, and pharmacy coupons, there are more ways than ever to reduce what you pay. This guide walks through every option.

How Much Does Entresto Cost Without Insurance?

The retail (cash) price of Entresto varies by pharmacy and dose, but here are the typical ranges for a 30-day supply (60 tablets):

• Brand-name Entresto 24/26 mg: $600–$700/month
• Brand-name Entresto 49/51 mg: $600–$700/month
• Brand-name Entresto 97/103 mg: $600–$700/month
• Generic Sacubitril/Valsartan (any strength): $45–$255/month (depending on pharmacy and discount card)

The dramatic price difference between brand and generic is the single biggest savings opportunity. If you're currently paying for brand-name Entresto, switching to the generic could save you $400 or more per month.

Option 1: Switch to Generic Sacubitril/Valsartan

This is the most impactful money-saving step. After Entresto's patent expired in July 2025, the FDA approved generic Sacubitril/Valsartan from multiple manufacturers. The generic is:

• Bioequivalent — same active ingredients, same strengths, same effectiveness
• FDA-approved — meets the same quality and safety standards
• Much cheaper — as low as $45/month with a discount card

Ask your doctor or pharmacist about switching. In most cases, your pharmacist can automatically substitute the generic unless your prescription specifically says "dispense as written." If it does, ask your doctor to update it.

Use Medfinder to find pharmacies near you that have generic Sacubitril/Valsartan in stock.

Option 2: Use a Pharmacy Discount Card or Coupon

Even without insurance, pharmacy discount cards can dramatically reduce the price of both brand and generic Sacubitril/Valsartan. These are free to use and accepted at most major pharmacies.

Here are some popular options:

• GoodRx: Shows prices at pharmacies near you and provides free coupons. Generic Sacubitril/Valsartan prices as low as $45 per month with a GoodRx coupon.
• SingleCare: Another free discount card with competitive pricing on generic Sacubitril/Valsartan
• RxSaver: Compares prices across pharmacies and offers printable or digital coupons
• Optum Perks: Formerly known as SearchRx, offers discounts at major chains
• BuzzRx: Free savings card accepted at over 60,000 pharmacies

Tip: Prices can vary significantly between pharmacies — even pharmacies on the same street. Always compare prices at multiple locations before filling your prescription. Discount cards work best for people who are uninsured or whose insurance copay is higher than the discount card price.

Option 3: Novartis Entresto Co-Pay Savings Card

If you have commercial (private) health insurance, the Novartis co-pay savings program can reduce your out-of-pocket cost for brand-name Entresto to as little as $10 per month.

Here's how it works:

• Available to patients with commercial insurance (not Medicare, Medicaid, or other government programs)
• Annual savings limit of $4,100
• Auto-renews each calendar year
• Sign up at entresto.com/financial-support or enrollsupport.entresto.com

Important: This co-pay card only applies to brand-name Entresto, not the generic. If your pharmacy fills the generic and your copay is already low, the savings card may not be necessary. But if your plan has a high copay for brand-name Entresto and won't cover the generic, this card can save you hundreds per month.

Option 4: Medicare Price Negotiation (Part D Beneficiaries)

If you're on Medicare Part D, 2026 brings significant savings. Entresto was one of the first 10 drugs selected for price negotiation under the Inflation Reduction Act.

Key details:

• Negotiated maximum fair price: approximately $295 per 30-day supply (starting January 2026)
• This is the price Medicare pays — your out-of-pocket cost depends on your plan's cost-sharing structure
• The $2,000 annual out-of-pocket cap on Part D spending (effective 2025) provides additional protection for patients taking expensive medications
• Many Medicare Part D plans are also covering generic Sacubitril/Valsartan at lower tier copays

Talk to your Medicare Part D plan to understand your specific cost-sharing. If you haven't reviewed your plan during open enrollment, it may be worth switching to a plan with better Sacubitril/Valsartan coverage.

Option 5: Patient Assistance Programs

If you're uninsured or underinsured and can't afford Entresto even at generic prices, patient assistance programs (PAPs) may be able to help:

Novartis Patient Assistance Foundation (NPAF)

Novartis has historically provided Entresto at no cost through its Patient Assistance Foundation for eligible patients who meet income requirements. Note: As generic versions have become available, Novartis has begun phasing out PAP support for Entresto, directing patients to more affordable generic alternatives. Check current eligibility at novartis.com or call 1-800-245-5356.

Other Assistance Resources

• NeedyMeds (needymeds.org) — searchable database of patient assistance programs, discount drug cards, and other cost-saving resources
• RxAssist (rxassist.org) — comprehensive database of pharmaceutical company patient assistance programs
• RxHope (rxhope.com) — helps patients apply for manufacturer-sponsored assistance programs
• State pharmaceutical assistance programs (SPAPs) — many states offer additional prescription drug assistance for low-income residents; check with your state's health department

Other Ways to Save on Entresto

Mail-Order Pharmacy

Many insurance plans offer mail-order pharmacy options that provide a 90-day supply at a lower per-month cost than filling 30 days at a time at a retail pharmacy. Check with your insurance plan to see if this option is available.

Pill Splitting (Not Recommended for Entresto)

Do not split Entresto tablets unless specifically instructed by your doctor. The tablets are designed to deliver precise doses of both Sacubitril and Valsartan, and splitting them can result in uneven dosing.

Shop Around

Pharmacy prices for the same medication can vary by $100 or more in the same zip code. Use Medfinder or a price comparison tool like GoodRx to find the lowest price near you before filling your prescription.

Ask About Samples

Your doctor's office may have Entresto samples from Novartis representatives. While samples don't provide a long-term solution, they can help bridge you through a period when you're waiting for insurance approval or a patient assistance program application to process.

Final Thoughts

No one should have to choose between their heart failure medication and their budget. With generic Sacubitril/Valsartan available for as low as $45 per month, the Novartis co-pay card offering $10/month for commercially insured patients, and Medicare's negotiated pricing at ~$295/month, there are real options to bring your Entresto costs down dramatically in 2026.

Start by asking your doctor about generic Sacubitril/Valsartan — for most patients, this alone solves the cost problem. Then check Medfinder to find the best price at a pharmacy near you.

For more on finding Entresto, see our guides on how to find Entresto in stock and why Entresto is hard to find in 2026. And if you're looking for a doctor who prescribes Entresto, check out how to find a doctor who can prescribe Entresto near you.