Having trouble finding Entresto at your pharmacy? Learn why Entresto can be hard to find in 2026, what's causing stock-outs, and what you can do right now.
You need Entresto to manage your heart failure, but your pharmacy just told you it's out of stock. Sound familiar? Thousands of patients across the country have run into this frustrating problem — and it's not your pharmacy's fault.
In this guide, we'll explain what Entresto is, why it can be hard to find, and — most importantly — what you can do to get your medication filled as quickly as possible.
Entresto (Sacubitril/Valsartan) is a prescription medication used to treat heart failure. It belongs to a class of drugs called angiotensin receptor-neprilysin inhibitors (ARNIs) and is manufactured by Novartis.
Entresto works by combining two active ingredients. Sacubitril blocks an enzyme called neprilysin, which allows helpful natural peptides to stay in your body longer. These peptides relax blood vessels, reduce fluid overload, and take pressure off the heart. Valsartan blocks angiotensin II receptors, which lowers blood pressure and reduces the strain on a weakened heart. You can learn more in our detailed guide on how Entresto works.
Entresto is FDA-approved for adults and children aged 1 year and older with heart failure. For adults with heart failure with reduced ejection fraction (HFrEF), it has been shown to reduce the risk of cardiovascular death and hospitalization compared to older treatments like Enalapril.
There are several reasons why you might have trouble finding Entresto at your local pharmacy in 2026:
Entresto has become one of the most prescribed heart failure medications in the United States. With approximately 6 million Americans living with heart failure — and guidelines increasingly recommending Entresto as first-line therapy — demand has grown significantly since its launch in 2015. Novartis reported $7.8 billion in Entresto sales in 2024 alone, which gives you an idea of just how widely this drug is used.
Entresto's core U.S. patent expired in July 2025, and the FDA approved the first generic versions of Sacubitril/Valsartan in mid-2024. While generic competition is great for lowering prices, the transition period can create temporary confusion and supply disruptions. Some pharmacies may be switching between brand and generic suppliers, and not all generic manufacturers may have ramped up production to full capacity yet.
Sacubitril/Valsartan is a complex combination drug that requires precise co-crystallization of two active ingredients. This manufacturing complexity means it's harder to produce than a simple single-ingredient generic. Supply chain disruptions — whether from raw material shortages, shipping delays, or quality control issues — can ripple through and cause localized stock-outs.
With Entresto being one of the first 10 drugs selected for Medicare price negotiation under the Inflation Reduction Act (with a negotiated price of about $295 per month starting in 2026), there has been a shift in how insurers handle the drug. Some plans may prefer generic Sacubitril/Valsartan over brand-name Entresto, which can create confusion at the pharmacy counter and temporary availability issues as supply chains adjust.
If your pharmacy doesn't have Entresto in stock, don't panic. Here are several steps you can take:
Medfinder lets you search for pharmacies near you that have Entresto in stock right now. Instead of calling pharmacy after pharmacy, you can check availability in seconds. Learn more in our guide on how to find Entresto in stock near you.
If your pharmacy is out of brand-name Entresto, ask your pharmacist or doctor about the generic version. Generic Sacubitril/Valsartan contains the same active ingredients and works the same way — and it's often significantly cheaper, with prices as low as $45 per month with a discount card.
Chain pharmacies tend to run out of high-demand medications faster. Independent pharmacies and specialty pharmacies that focus on cardiovascular medications may have better stock. They can also often special-order medications and get them within 1-2 business days.
If you absolutely cannot find Entresto and are at risk of running out, talk to your doctor. They may be able to prescribe a temporary alternative medication — like an ACE inhibitor (Enalapril) or an ARB (Valsartan) — to keep you covered until Entresto is back in stock.
Don't wait until your last pill to refill. Try to request refills at least 7-10 days before you run out. This gives your pharmacy time to order the medication if it's not currently on the shelf.
Entresto is an essential medication for many heart failure patients, and running into availability issues can be scary. The good news is that with generics now on the market and Medicare pricing reforms taking effect in 2026, both access and affordability are improving.
If you're struggling to find Entresto, start by checking Medfinder for real-time pharmacy availability near you. And if cost is a concern, read our guide on how to save money on Entresto in 2026.
You shouldn't have to worry about finding the medication that keeps your heart working. We're here to help.
You focus on staying healthy. We'll handle the rest.
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