Brexafemme Is Expensive — But There Are Ways to Pay Less

Brexafemme (Ibrexafungerp) is a groundbreaking antifungal for vaginal yeast infections, but its price tag can be shocking. Without insurance, a single treatment course of Brexafemme costs between $450 and $600. That's a lot to pay for a one-day treatment — even if it works better for your particular infection than cheaper options.

In this guide, we'll break down the real cost of Brexafemme, explain every way to save money on it, and help you figure out which option works best for your situation.

Important note: Brexafemme has been temporarily unavailable since 2023 due to a recall and FDA hold. The information below applies when the drug is commercially available. If you're able to find it in stock, these savings strategies can help you afford it.

How Much Does Brexafemme Cost Without Insurance?

Brexafemme comes as 150 mg oral tablets. A standard treatment requires 4 tablets (two doses of 300 mg, taken 12 hours apart in a single day). Here's what you can expect to pay:

• Average cash price: $538 to $585 for 4 tablets
• Lowest reported prices: Around $450 at some pharmacies with discount cards
• Highest reported prices: Up to $600 or more at certain retail pharmacies

For women using Brexafemme for recurrent VVC prevention (monthly dosing for 6 months), the total cost without insurance could exceed $2,700 to $3,600 — that's 6 treatment courses over 6 months.

There is no generic version of Ibrexafungerp available as of 2026, which means there's no lower-cost generic option to fall back on.

Coupons and Discount Cards

Pharmacy discount cards can sometimes reduce the cash price of Brexafemme. Here are the major programs to check:

SingleCare

SingleCare has listed Brexafemme coupon prices starting around $501 for 4 tablets. You can print a free coupon at singlecare.com/prescription/brexafemme and present it at the pharmacy. No insurance required.

GoodRx

GoodRx may offer discounted pricing for Brexafemme. Check goodrx.com/brexafemme for the latest prices at pharmacies near you. Prices vary by location.

Other Discount Programs

Additional discount card programs worth checking include:

• RxSaver — rxsaver.com
• Optum Perks — perks.optum.com
• BuzzRx — buzzrx.com
• Inside Rx — insiderx.com
• America's Pharmacy — americaspharmacy.com

Prices across these programs typically range from $450 to $585 for a 4-tablet course. Compare several programs before filling your prescription — prices can vary significantly between pharmacies and discount cards.

Manufacturer Copay Assistance

When Brexafemme was commercially available, Scynexis (the manufacturer) offered a copay assistance savings program for eligible patients. Key details:

• Copay as low as $30 per prescription for eligible commercially insured patients
• No activation required — the pharmacy could process the savings card directly
• Not available for patients on government-funded insurance (Medicare, Medicaid, Tricare, VA)

This was one of the best ways to reduce out-of-pocket cost from hundreds of dollars to just $30. If Brexafemme returns to the market, check with the manufacturer or your pharmacy about whether this program is still active.

Patient Assistance Programs

If you're uninsured or underinsured and can't afford Brexafemme, patient assistance programs (PAPs) may help. These programs provide medications at reduced cost or free of charge to qualifying patients.

Where to Look

• NeedyMeds (needymeds.org) — Search for Brexafemme or Ibrexafungerp to find current assistance programs
• RxAssist (rxassist.org) — A comprehensive database of patient assistance programs organized by drug
• RxHope (rxhope.com) — Helps connect patients with manufacturer-sponsored assistance programs

Eligibility

Patient assistance programs typically require:

• Proof of income (often at or below 200-400% of the federal poverty level)
• No prescription drug insurance, or demonstrated financial hardship
• U.S. residency
• A valid prescription from a licensed prescriber

Application processing can take several weeks, so apply early if you anticipate needing the medication.

Insurance Coverage for Brexafemme

If you have health insurance, Brexafemme may be covered — but coverage varies widely:

• Commercial insurance: Many plans cover Brexafemme but may require prior authorization (your doctor must submit documentation showing medical necessity) and/or step therapy (you must try Fluconazole first)
• Medicare Part D: Some plans cover Brexafemme. With the $2,000 annual out-of-pocket cap (effective since 2025), your total yearly costs for all medications are limited
• Medicaid: Coverage varies by state

Tips for navigating insurance:

• Ask your doctor to submit a prior authorization if your plan requires it
• If denied, request a formulary exception — especially if you have documented azole resistance or Fluconazole treatment failure
• Check your plan's formulary online or call member services to verify coverage before filling

Other Ways to Save

Compare Pharmacy Prices

Prices for Brexafemme can vary by $100 or more between pharmacies in the same area. Use Medfinder to search for availability and compare options. Independent pharmacies sometimes offer lower prices than chains.

Ask About Therapeutic Alternatives

If cost is a major barrier, talk to your doctor about whether a less expensive alternative would work for your situation:

• Fluconazole (generic): $4 to $15 for a single treatment
• Miconazole (Monistat): $10 to $20 OTC
• Clotrimazole: $7 to $15 OTC

These options won't work for everyone — especially those with azole-resistant infections — but for many women, they're effective and dramatically cheaper. See our full comparison in alternatives to Brexafemme.

Ask Your Doctor for Samples

When pharmaceutical reps are actively marketing a drug, doctors sometimes receive samples. This is less likely during the current shortage, but worth asking about if Brexafemme returns to the market.

Final Thoughts

Brexafemme is an expensive medication — there's no way around it. At $450 to $600 per treatment course with no generic alternative, cost is a real barrier for many patients. But between manufacturer copay assistance (as low as $30), pharmacy discount cards ($450 to $585), patient assistance programs, and insurance coverage, there are meaningful ways to reduce what you pay.

If Brexafemme is currently unavailable, these savings strategies will be ready for you when the drug returns to the market. In the meantime, check Medfinder for the latest availability, and talk to your doctor about affordable alternatives to keep your yeast infections under control.