The Everolimus Supply Situation in 2026

If you rely on Everolimus — whether it's Afinitor for cancer treatment or Zortress for transplant rejection — you've probably experienced the frustration of hearing "we don't have that in stock" at least once. Everolimus supply has been unpredictable in recent years, and many patients are still dealing with availability challenges in 2026.

This article gives you an honest, up-to-date look at the Everolimus shortage situation: what's happening, why it's happening, what it costs, and what you can do about it.

Is Everolimus Still in Shortage?

Everolimus has not been in a continuous, nationwide shortage, but it has experienced intermittent supply disruptions that affect specific strengths and formulations. In 2026, the situation looks like this:

• Brand-name Afinitor (Novartis) is generally available through specialty pharmacies, but may not always be stocked at retail pharmacies
• Afinitor Disperz (the dispersible tablet form) can be harder to find due to lower production volumes
• Generic Everolimus tablets are available from multiple manufacturers, which has improved overall supply — but certain strengths (2.5 mg, 7.5 mg) may periodically be limited
• Zortress (transplant formulation) has its own supply stream and is typically available through transplant specialty pharmacies

The FDA's drug shortage database may list specific Everolimus products as having limited availability. Check with your pharmacy or use Medfinder for the most current stock information in your area.

Why Is Everolimus Hard to Find?

Several factors contribute to the ongoing availability challenges:

Complex Manufacturing

Everolimus is a complex molecule that requires specialized manufacturing processes. Any disruption — equipment issues, raw material shortages, or regulatory compliance matters — can reduce output for weeks or months.

Specialty Distribution

Unlike common medications that are distributed to thousands of retail pharmacies, Everolimus moves through a more limited specialty pharmacy network. This means fewer locations stock it, and when demand spikes in a region, local supply can dry up quickly.

Insurance and Access Barriers

Prior authorization requirements and specialty pharmacy mandates can create bottlenecks. Even when the drug is physically available, administrative delays can make it feel like a shortage from the patient's perspective.

For a deeper explanation, read why Everolimus is so hard to find in 2026.

What Does Everolimus Cost in 2026?

Everolimus is an expensive medication. Here's what you can expect:

• Brand-name Afinitor (10 mg, 30 tablets): Approximately $15,000 to $22,000 per month without insurance
• Generic Everolimus (10 mg, 30 tablets): Approximately $500 to $3,000 per month, depending on the pharmacy and discount programs used
• Zortress: Lower per-tablet cost due to smaller doses, but still several hundred dollars per month without insurance

Most patients don't pay the full cash price. Insurance, manufacturer copay programs, and patient assistance foundations can dramatically reduce your out-of-pocket costs. Learn more in our guide on how to save money on Everolimus.

Are There New Options in 2026?

The availability of generic Everolimus has been the most significant positive development in recent years. Multiple manufacturers now produce generic versions, which has:

• Increased overall supply
• Reduced costs for many patients
• Given pharmacies more sourcing options

Additionally, the ongoing development of new targeted therapies means that for some conditions, doctors have more treatment options than ever before. If you're interested in alternatives, check out our article on alternatives to Everolimus.

How to Find Everolimus in Stock

Here are the most effective steps you can take right now:

1. Use Medfinder to check which pharmacies near you have Everolimus in stock
2. Work with a specialty pharmacy — they're most likely to have it and can ship to your home
3. Ask your doctor's office — they often have direct lines to specialty pharmacies and distributors
4. Request generic Everolimus if you're currently on brand-name Afinitor — it may be easier to find
5. Plan ahead — start refills 7 to 10 days early to account for sourcing and prior authorization delays

For detailed tips, read our full guide on how to find Everolimus in stock near you.

Final Thoughts

The Everolimus supply situation in 2026 isn't a crisis, but it's far from smooth. Intermittent disruptions, specialty pharmacy requirements, and high costs continue to make this medication harder to access than it should be.

The best thing you can do is stay informed, plan ahead, and use every resource available — from Medfinder for stock checks to patient assistance programs for financial help. Your care team is your best ally in navigating these challenges, so don't hesitate to reach out to them when you need help.

For information about side effects and what to watch for, visit our guide on Everolimus side effects.