Cytomel Shortage Update: What Patients Need to Know in 2026

If you rely on Cytomel (Liothyronine Sodium) to manage your thyroid condition, the ongoing supply challenges have probably tested your patience. In this 2026 update, we'll cover the current state of Cytomel availability, why shortages keep happening, what it costs today, and your best options for getting your prescription filled.

Is Cytomel Still in Shortage in 2026?

The situation in 2026 is best described as "tight but not impossible." Cytomel and generic Liothyronine are not consistently listed on the FDA's official drug shortage database, but real-world availability tells a different story. Many patients report that their regular pharmacy is frequently out of stock, needs to order it, or can only provide partial fills.

The shortage isn't a single event — it's a pattern of intermittent supply disruptions that has persisted since the broader thyroid medication supply issues began around 2018. Some months are better than others, and availability varies significantly by region and pharmacy.

Why Is Cytomel Hard to Find?

Several factors contribute to the ongoing Cytomel supply challenges:

Few Manufacturers

Only a handful of companies manufacture Liothyronine tablets. Pfizer makes brand-name Cytomel, and a limited number of generic manufacturers produce Liothyronine Sodium. When any single manufacturer hits a production snag, the effects cascade through the supply chain.

Growing Demand

More healthcare providers are recognizing the value of T3 supplementation for hypothyroid patients who don't feel well on T4 (Levothyroxine) alone. This is especially true in integrative and functional medicine. As more prescriptions are written, the fixed supply gets stretched thinner. For more background, see why Cytomel is so hard to find.

Levothyroxine Shortage Spillover

The Levothyroxine shortage that escalated in 2023-2025 pushed some prescribers and patients toward Liothyronine, further straining an already limited supply.

Pharmaceutical Tariffs

Tariffs on imported pharmaceutical ingredients introduced in 2025 have added manufacturing costs and may be contributing to production decisions that affect supply.

How Much Does Cytomel Cost in 2026?

Cost remains a real concern for many patients:

• Brand-name Cytomel: Approximately $80 to $300+ per month at retail cash price, depending on dose and quantity
• Generic Liothyronine: Approximately $80 to $100 retail, but as low as $24 to $30 with discount coupons from GoodRx, SingleCare, or other programs
• With insurance: Co-pays for generic Liothyronine typically range from $5 to $30, depending on your plan

For detailed savings strategies, read our guide on how to save money on Cytomel.

New Options and Developments

While no major new T3 products have launched recently, there are some developments worth noting:

• Compounded Liothyronine has become increasingly popular, with more compounding pharmacies offering sustained-release T3 formulations
• Combination therapy (Levothyroxine + Liothyronine) continues to gain acceptance as a treatment approach
• Telehealth prescribing has made it easier to find doctors who are willing to prescribe T3 medications — see how to find a doctor who prescribes Cytomel

How to Find Cytomel in Stock

Here are the best strategies for locating Cytomel right now:

1. Use Medfinder — search for Cytomel or Liothyronine to find pharmacies near you with current stock
2. Try independent pharmacies — they often have more flexible supply chains than large chains
3. Ask about different strengths — sometimes one tablet strength is available while another is backordered. Your doctor can adjust your prescription accordingly
4. Consider mail-order pharmacies — they may have access to larger inventories
5. Explore compounding pharmacies — if commercial products are unavailable, a compounding pharmacy can prepare Liothyronine to your doctor's specifications

For a complete walkthrough, see how to find Cytomel in stock near you.

What to Do If You're Running Out

If you're down to your last few days of Cytomel, take these steps immediately:

• Call your doctor's office — they may have samples or can call in a prescription to a pharmacy that has stock
• Ask your pharmacist about a partial fill — getting even a few days' supply buys you time
• Don't skip doses silently — let your doctor know so they can monitor your thyroid levels and adjust as needed
• Consider a temporary alternative — your doctor may bridge you with an alternative medication until Cytomel is back in stock

Final Thoughts

The Cytomel supply situation in 2026 remains challenging but manageable with the right approach. Stay proactive: fill prescriptions early, use Medfinder to find pharmacies with stock, explore all your options, and keep an open line of communication with your doctor.

Your thyroid health is too important to leave to chance. The medication is out there — it just takes a little more effort to find it right now.