Baloxavir Marboxil Shortage Update for 2026

If you have been told your pharmacy is out of Baloxavir Marboxil (brand name Xofluza), you are experiencing what many patients across the country have dealt with during the 2025-2026 flu season. Availability of this popular single-dose flu treatment has been inconsistent, and patients are understandably frustrated.

This article gives you the latest information on the Baloxavir Marboxil shortage, explains what is causing it, and outlines what you can do to get treated as quickly as possible.

Current Status: Is Baloxavir Marboxil in Shortage?

As of early 2026, Baloxavir Marboxil is not formally listed on the FDA's official drug shortage database. However, many pharmacies have reported intermittent stock-outs, especially during peak flu months (December through March). This means the drug is technically being manufactured and distributed, but demand is outpacing what is available on pharmacy shelves in many areas.

This type of shortage—where the drug exists but is hard to find locally—is sometimes called a "practical shortage" or "spot shortage." It is especially common with seasonal medications like Xofluza that see sudden demand spikes.

What Is Causing the Shortage?

Several factors are contributing to the difficulty in finding Baloxavir Marboxil this flu season:

• High flu activity: The 2025-2026 flu season has seen significant flu activity across the United States, driving up demand for antiviral treatments.
• Single manufacturer: Xofluza is made only by Genentech (a Roche company). There is no generic version, so all supply comes from one source.
• Seasonal stocking challenges: Pharmacies must predict how much Xofluza to order before flu season begins. When flu hits harder or earlier than expected, pre-season inventory may not be enough.
• Growing popularity: More patients and doctors are choosing Xofluza for its single-dose convenience, increasing demand compared to previous years.

For a deeper dive into these factors, see our article on why Baloxavir Marboxil is so hard to find.

Shortage History

This is not the first time Xofluza has been difficult to find. Similar availability challenges occurred during the 2022-2023 and 2023-2024 flu seasons, when flu activity spiked and pharmacies ran low on stock. Each year, availability typically improves as flu season winds down in the spring.

When Will the Shortage End?

Based on historical patterns, availability of Baloxavir Marboxil usually improves after flu season peaks, which is typically in late February or March. As fewer people get the flu, demand drops and pharmacies are able to restock. However, if a second wave of flu activity occurs later in the season, shortages could persist longer.

Genentech has not announced any long-term supply disruptions. The current challenges appear to be demand-driven rather than caused by manufacturing problems.

What Should Patients Do Right Now?

If you need Baloxavir Marboxil and cannot find it, take these steps:

1. Search for availability online. Use MedFinder to find pharmacies near you that may have Xofluza in stock. See our full guide on how to find Baloxavir Marboxil in stock near you.
2. Call multiple pharmacies. Check large chains, grocery store pharmacies, and independent pharmacies. Learn more tips in our article on how to check if a pharmacy has Baloxavir Marboxil in stock.
3. Ask about alternatives. Your doctor can prescribe Oseltamivir (Tamiflu), Zanamivir (Relenza), or other flu antivirals if Xofluza is unavailable. Read about alternatives to Baloxavir Marboxil.
4. Consider telehealth. Telehealth providers can often send prescriptions to pharmacies that have the medication in stock, saving you time.
5. Look into savings programs. If cost is a barrier, learn about coupons and discounts for Baloxavir Marboxil.

How to Stay Informed

To stay updated on the Baloxavir Marboxil shortage:

• Check the FDA Drug Shortages Database for any formal shortage listings.
• Visit MedFinder regularly for the latest availability information.
• Follow Genentech or Xofluza on their official channels for supply updates.

Protecting Yourself During Flu Season

While dealing with medication availability is stressful, there are things you can do to protect yourself:

• Get your flu vaccine. The flu vaccine is still the best way to prevent the flu in the first place.
• Practice good hygiene. Wash your hands frequently, avoid touching your face, and stay home if you are sick.
• Seek treatment early. If you do get the flu, see a doctor within 48 hours of symptom onset so you can start antiviral treatment as soon as possible.

The Bottom Line

The Baloxavir Marboxil shortage in 2026 is driven mainly by seasonal demand, limited supply from a single manufacturer, and the drug's growing popularity. While it is not a formal FDA-listed shortage, real-world availability has been spotty. Use tools like MedFinder, call pharmacies proactively, and work with your doctor to find the best treatment option—whether that is Xofluza or an alternative. The most important thing is getting treated quickly.