Is Amitiza in shortage in 2026? Get the latest update on Lubiprostone availability, pricing, and what you can do if your pharmacy is out of stock.
If you've had trouble finding Amitiza (Lubiprostone) at your pharmacy lately, you may be wondering whether there's an official drug shortage. Here's the latest information as of early 2026 — plus practical steps you can take to keep your treatment on track.
As of early 2026, Amitiza (Lubiprostone) is not listed on the FDA's official drug shortage database. This means there is no formally declared national shortage of the medication.
However, that doesn't mean it's easy to find everywhere. Many patients have reported intermittent availability issues at individual pharmacies. This is sometimes called a "soft shortage" — the drug is being manufactured, but it's not consistently stocked at every pharmacy location.
The situation has actually improved since 2024-2025, when Amitiza's patents expired and generic Lubiprostone entered the market. More manufacturers producing the drug means more overall supply. But distribution gaps remain, especially in certain regions.
Even without a formal shortage, several factors can make it difficult to fill your prescription:
While generic Lubiprostone is available, only a handful of manufacturers produce it. Any disruption at one facility can cause ripple effects across the supply chain.
Pharmacies decide what to stock based on local demand. Lubiprostone is a relatively specialty medication — it's not as commonly prescribed as, say, a statin or a blood pressure pill. If your pharmacy doesn't regularly fill Lubiprostone prescriptions, they may not keep it in stock.
Prior authorization requirements and step therapy mandates from insurance companies can create delays. Even when a pharmacy has the drug, insurance hurdles can prevent you from getting it quickly. For details, see: Why Is Amitiza So Hard to Find?
Cost is a major concern for many patients, especially those without adequate insurance coverage:
For tips on reducing your costs, read: How to Save Money on Amitiza in 2026.
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Here are the most effective steps you can take today:
Use Medfinder to search for real-time Amitiza and Lubiprostone availability at pharmacies near you. It's the fastest way to find out who has it in stock without calling around.
If your prescription is for brand-name Amitiza, ask your doctor or pharmacist about switching to generic Lubiprostone. The generic is often easier to find and costs significantly less.
Independent pharmacies work with multiple wholesalers and may have access to inventory that chain pharmacies don't. They can also often special-order medications within a day or two.
Mail-order pharmacies typically maintain larger inventories. Ask your insurance company about mail-order options that cover Lubiprostone — you may be able to get a 90-day supply delivered to your door.
If you've been unable to find Amitiza for more than a week, contact your doctor. They can help you find a pharmacy with stock, switch you to an available alternative, or provide samples to bridge the gap.
For more detailed strategies, see: How to Find Amitiza in Stock Near You.
Whether you're taking brand-name Amitiza or switching to generic Lubiprostone, the side effect profile is the same. The most common side effect is nausea, which affects up to 29% of patients. Taking the medication with food and water helps reduce this.
For a complete guide to side effects, see: Amitiza Side Effects: What to Expect and When to Call Your Doctor.
While Amitiza is not in an official shortage in 2026, many patients still face challenges finding it at their local pharmacies. The good news is that generic Lubiprostone has improved supply, costs are lower than ever for the generic, and effective alternatives are readily available. Stay proactive by using tools like Medfinder, communicating with your doctor, and exploring all your options.
You focus on staying healthy. We'll handle the rest.
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