Amitiza can cost over $500/month. Learn how to save with generic Lubiprostone, discount cards, coupons, and patient assistance programs in 2026.
If you've ever looked at the price tag for Amitiza (Lubiprostone) without insurance, you know it can be a shock. Brand-name Amitiza costs around $400 to $530 per month for a 30-day supply of the 24 mcg capsules. Even with insurance, copays can be steep depending on your plan.
The good news? In 2026, there are more ways than ever to bring that cost down. From generic versions to discount cards to patient assistance programs, this guide covers every option available to help you save money on your Amitiza prescription.
Here's what you can expect to pay out of pocket in 2026 without insurance or discount programs:
That's right — generic Lubiprostone can save you up to 85% compared to brand-name Amitiza. If you're currently paying for the brand, switching to generic is the single biggest savings opportunity.
The most impactful step you can take is switching from brand-name Amitiza to generic Lubiprostone. Here's what you need to know:
If your prescription currently specifies brand-name Amitiza, ask your doctor to change it to allow generic substitution. This one change could save you $300 to $400 per month.
Even if you're already getting the generic, discount cards can help you save even more. These free programs negotiate lower prices with pharmacies on your behalf:
Pro tip: Prices through discount cards can vary by $20 to $50+ between pharmacies. Always compare prices across at least 2-3 pharmacies before filling your prescription. Independent pharmacies sometimes offer the best discount card prices.
Important: Discount cards cannot be used together with insurance. Use whichever option gives you the lower price. If your insurance copay is $100 but a discount card offers the generic for $70, use the discount card.
If you're uninsured, underinsured, or facing financial hardship, patient assistance programs (PAPs) can provide Lubiprostone at little or no cost. Here are the key programs:
Mallinckrodt Pharmaceuticals, which owns Amitiza, offers a patient assistance program for qualifying patients. Eligibility typically requires:
Contact Mallinckrodt directly or ask your doctor's office to help you apply.
NeedyMeds.org is a nonprofit database that lists patient assistance programs, discount drug cards, and other cost-saving resources. Search for "Lubiprostone" or "Amitiza" to find all available programs.
RxAssist.org is another comprehensive database of patient assistance programs. It's particularly useful for finding manufacturer-sponsored programs and state-level assistance.
RxHope.com connects patients with available assistance programs and can help you navigate the application process.
Many insurance plans and mail-order pharmacies offer a lower per-dose cost for 90-day supplies compared to 30-day fills. Ask your doctor to write a 90-day prescription and check with your insurance about mail-order options. You might save $10 to $30 per fill compared to monthly refills.
Prices for the same generic medication can vary dramatically between pharmacies — sometimes by $50 or more. Use Medfinder to find pharmacies with Lubiprostone in stock, then compare prices using discount card apps.
Some states offer prescription assistance programs for residents who meet certain income requirements. Contact your state's department of health or aging services to see if you qualify for any local programs.
Takeda, which markets Amitiza, has historically offered copay assistance cards that reduce out-of-pocket costs for patients with commercial insurance. Check amitiza.com or call the number on your Amitiza packaging to see if a current savings program is available. Note that copay cards typically don't work with government insurance (Medicare, Medicaid, Tricare).
If cost remains a barrier even after exploring all savings options, discuss alternatives to Amitiza with your doctor. Depending on your insurance formulary, another medication like Linzess, Trulance, or Motegrity might have a lower copay.
Nobody should have to choose between their budget and their health. In 2026, the availability of generic Lubiprostone has made Amitiza significantly more affordable for most patients. Combine the generic with a discount card, and you could save hundreds of dollars every month. If you're still struggling with costs, patient assistance programs can help bridge the gap.
Start by asking your doctor about switching to generic Lubiprostone, then use Medfinder to find a pharmacy near you that has it in stock at the best price.
You focus on staying healthy. We'll handle the rest.
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