Comprehensive medication guide to Zomacton including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$150 copay per fill for commercially insured patients; Tier 3–4 specialty on most plans. Ferring's copay savings card can reduce out-of-pocket costs by up to $500/month for eligible patients. Prior authorization required on virtually all plans.
Estimated Cash Pricing
$620–$707 retail per 10 mg vial (brand only; no generic available); approximately $569 with SingleCare coupon for a single vial. Monthly cost varies significantly by prescribed dose and patient weight.
Medfinder Findability Score
55/100
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Zomacton is a brand-name prescription growth hormone medication manufactured by Ferring Pharmaceuticals. Its active ingredient is somatropin — a recombinant human growth hormone (rHGH) that is biologically identical to the growth hormone naturally produced by the pituitary gland. Zomacton has been FDA-approved for pediatric growth conditions since 1995 and received approval for adult growth hormone deficiency in January 2018.
Zomacton is indicated for pediatric patients with growth failure due to growth hormone deficiency (GHD), Turner syndrome, idiopathic short stature (ISS), SHOX deficiency, and short stature born small for gestational age (SGA) with no catch-up growth by ages 2-4. For adults, it is used to replace endogenous growth hormone in patients with GHD.
Zomacton is available as a lyophilized powder in 5 mg and 10 mg single-patient-use vials that must be reconstituted before subcutaneous injection. An optional needle-free delivery device (ZOMA-Jet) is available for the 5 mg formulation. There is no generic version of Zomacton available in the United States.
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Zomacton works by replacing the growth hormone your pituitary gland is not producing in sufficient amounts. The active ingredient somatropin is a 191-amino-acid recombinant polypeptide with a molecular weight of approximately 22,124 daltons — chemically identical to natural pituitary-derived human growth hormone. It is manufactured using recombinant DNA technology by inserting the human GH gene into E. coli bacteria.
After subcutaneous injection, somatropin enters the bloodstream and binds to growth hormone receptors on the liver and other target tissues. This triggers the liver to produce insulin-like growth factor 1 (IGF-1), which mediates most of growth hormone's biological effects: stimulating cartilage cell proliferation at the growth plates (in children with open epiphyses), increasing cellular protein synthesis, promoting fat breakdown (lipolysis), and helping maintain bone density and body composition in adults.
Serum IGF-1 levels are used clinically to monitor the effectiveness of Zomacton treatment and guide dose adjustments. Growth hormone also has counter-regulatory effects on insulin signaling, which is why blood glucose monitoring is recommended during therapy, particularly for patients with existing diabetes or risk factors for glucose intolerance.
5 mg — injection (lyophilized powder for reconstitution)
Co-packaged with bacteriostatic 0.9% sodium chloride (0.9% benzyl alcohol). Use within 14 days after reconstitution. ZOMA-Jet needle-free device available.
10 mg — injection (lyophilized powder for reconstitution)
Co-packaged with bacteriostatic water for injection (0.33% metacresol). Use within 28 days after reconstitution. Benzyl alcohol-free formulation.
Zomacton is not listed on the FDA's Drug Shortage Database as of 2026, meaning there is no active national supply shortage. However, it is a specialty pharmacy-only medication, and most retail pharmacies do not stock it. Patients are commonly surprised to find that their local CVS or Walgreens cannot fill the prescription — Zomacton requires cold-chain handling, reconstitution, and specialized billing that only specialty pharmacies are equipped to provide.
Access barriers that patients commonly experience include insurance prior authorization delays (typically 3-14 business days), restricted specialty pharmacy networks where plans only cover certain pharmacies, and formulary non-preference on some insurance plans that require step therapy through a preferred somatropin brand. Cash prices without assistance are high — approximately $620-$707 per 10 mg vial at retail.
If you are having trouble locating a pharmacy with Zomacton in stock, medfinder calls pharmacies near you and texts you results showing which ones can fill your prescription — saving you hours of hold time and phone calls.
Zomacton is not a controlled substance, so it can be prescribed by any licensed physician. In practice, it is almost always managed by endocrinology specialists because diagnosis requires specialized testing (GH stimulation tests, IGF-1 levels, bone age X-rays) and ongoing monitoring. Most insurance plans require the prescribing authority to be a qualified specialist for prior authorization approval.
Prescriber types who commonly manage Zomacton therapy:
Telehealth availability for Zomacton is limited: initial diagnosis requires in-person testing, but established patients may be able to receive follow-up care and prescription renewals through telehealth endocrinology services in their state. Ask your current specialist whether telehealth follow-up appointments are available.
No. Zomacton (somatropin) is not classified as a controlled substance under the DEA Controlled Substances Act. It is a Schedule-unscheduled prescription biologic, meaning it does not have the prescribing restrictions associated with Schedule II-V controlled drugs.
This means prescriptions for Zomacton can be called in or faxed electronically, do not require paper prescriptions, can include refills on the same prescription (up to the number authorized by your doctor), and are not subject to DEA quantity limit rules. However, Zomacton does require a valid prescription from a licensed healthcare provider and is not available over the counter. Most insurance plans also require prior authorization before dispensing, regardless of its controlled substance status.
The most frequently reported side effects (occurring in ≥10% of patients in clinical trials) include:
Serious side effects requiring medical attention:
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Norditropin (somatropin)
Novo Nordisk. Prefilled FlexPro pens (5 mg, 10 mg, 15 mg, 30 mg); no reconstitution required; can store at room temperature up to 3 weeks for 5 and 10 mg pens. Often formulary-preferred. Same active ingredient as Zomacton.
Genotropin (somatropin)
Pfizer. Multiple delivery systems including pen cartridges and MiniQuick single-dose syringes (no refrigeration before use). Widely covered on commercial plans. Same active ingredient as Zomacton.
Omnitrope (somatropin)
Sandoz. Generally the lowest-cost somatropin option. Available as pen and vials. Often Tier 1-2 on commercial formularies. Same active ingredient as Zomacton.
Skytrofa (lonapegsomatropin)
Ascendis Pharma. Once-weekly dosing for pediatric GHD patients ≥1 year, ≥11.5 kg. Not approved for adults. May improve adherence for patients who struggle with daily injections.
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Glucocorticoids (prednisone, hydrocortisone, dexamethasone)
moderateCan inhibit growth-promoting effects of somatropin and suppress IGF-1 production. Careful dose management of both agents required; hypoadrenalism risk in patients on replacement glucocorticoids.
Insulin and oral hypoglycemic agents
moderateZomacton decreases insulin sensitivity; may increase blood glucose levels. Doses of antidiabetic medications may need to increase after starting Zomacton. Monitor glucose regularly.
Oral estrogens (contraceptives, HRT)
moderateOral estrogen reduces hepatic GH response, lowering IGF-1 levels. Higher Zomacton doses may be required. Transdermal estrogen does not have the same effect.
Levothyroxine (thyroid hormone replacement)
moderateSomatropin can unmask or worsen hypothyroidism and may reduce thyroid hormone levels. Monitor thyroid function periodically and adjust levothyroxine dose as needed.
CYP450-metabolized drugs (cyclosporine, anticonvulsants, statins)
minorGrowth hormone may alter the clearance of CYP450-metabolized drugs. Monitor drug levels and clinical response; dose adjustments may be needed.
Zomacton is a clinically effective and well-established recombinant human growth hormone that has been helping children grow and adults maintain metabolic health since 1995. Manufactured by Ferring Pharmaceuticals, it is one of several FDA-approved somatropin products available in the United States and is backed by decades of clinical evidence.
The biggest challenges with Zomacton are not clinical — they are logistical and financial. As a specialty-only biologic with no generic available, patients must navigate prior authorization, specialty pharmacy networks, and potentially high out-of-pocket costs. Ferring's savings programs (up to $6,000/year for eligible uninsured patients; up to $500/month for insured patients) can significantly reduce the financial burden for those who qualify.
If you're struggling to find which specialty pharmacy near you has Zomacton in stock, medfinder is a paid service that calls pharmacies on your behalf and texts you results — helping you get your prescription filled faster without hours spent on hold.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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