Comprehensive medication guide to Tribenzor including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$60 copay depending on formulary tier; brand may require prior authorization and step therapy documentation; generic typically Tier 2–3. Commercially insured patients may pay as little as $5/month with the Cosette savings card.
Estimated Cash Pricing
$326–$600 retail for brand Tribenzor; as low as $36–$70 with GoodRx or SingleCare coupons for generic olmesartan/amlodipine/HCTZ for a 30-day supply.
Medfinder Findability Score
76/100
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Tribenzor is a brand-name prescription tablet that combines three blood pressure medications into one daily dose. First approved by the FDA in 2010, it is currently marketed by Cosette Pharmaceuticals, Inc. Generic versions (olmesartan/amlodipine/hydrochlorothiazide) are available from multiple manufacturers including Teva and Par Health USA.
Tribenzor is FDA-approved for the treatment of high blood pressure (hypertension) in adults who have not achieved adequate control on any two of the following drug classes: angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs), or thiazide diuretics. It is specifically indicated as substitution or add-on therapy — it is not for patients trying blood pressure medication for the first time.
The three active ingredients are olmesartan medoxomil (20 or 40 mg), amlodipine (5 or 10 mg), and hydrochlorothiazide (12.5 or 25 mg), combined in five available strength combinations taken once daily.
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Tribenzor lowers blood pressure through three complementary mechanisms, each targeting a different physiological pathway. This multi-pronged approach explains why it's effective for patients who haven't responded to simpler regimens.
Olmesartan (ARB): Blocks angiotensin II receptors, preventing a hormone that narrows blood vessels from activating. This relaxes blood vessel walls and reduces vascular resistance.
Amlodipine (CCB): Blocks L-type calcium channels in artery smooth muscle cells. Less calcium entry means muscles stay more relaxed, keeping arteries wider and reducing resistance to blood flow.
Hydrochlorothiazide (HCTZ): Acts on the kidneys to prevent sodium reabsorption, increasing urine production. This reduces blood volume, which in turn lowers the pressure blood exerts on artery walls.
20 mg / 5 mg / 12.5 mg — tablet
Starting dose; olmesartan 20 mg / amlodipine 5 mg / HCTZ 12.5 mg
40 mg / 5 mg / 12.5 mg — tablet
Olmesartan 40 mg / amlodipine 5 mg / HCTZ 12.5 mg
40 mg / 5 mg / 25 mg — tablet
Olmesartan 40 mg / amlodipine 5 mg / HCTZ 25 mg
40 mg / 10 mg / 12.5 mg — tablet
Olmesartan 40 mg / amlodipine 10 mg / HCTZ 12.5 mg
40 mg / 10 mg / 25 mg — tablet
Maximum dose; olmesartan 40 mg / amlodipine 10 mg / HCTZ 25 mg
As of 2026, Tribenzor is not on the FDA's drug shortage list and generic versions are produced by multiple manufacturers. Most patients can find it with some effort — but it's not universally stocked at every pharmacy. The five different strength combinations each need to be ordered separately, and lower dispensing volume means pharmacies maintain less buffer stock than for common single-ingredient medications.
Patients most commonly run into stock gaps when their specific strength isn't on a pharmacy's regular order, or when different distributors serving different pharmacy chains experience minor supply variations. Larger chain pharmacies and mail-order pharmacies tend to have broader inventory. Independent pharmacies can often special-order within 1–2 days.
If you're having trouble locating Tribenzor at your local pharmacy, medfinder can call pharmacies near you to find which ones have your specific strength in stock, saving you the time and frustration of calling each one yourself.
Tribenzor is not a controlled substance, so any licensed prescriber with prescription-writing authority can prescribe it without special DEA registration. It is typically prescribed for patients with hypertension not adequately controlled on simpler regimens.
Cardiologists — particularly for patients with resistant hypertension or cardiovascular comorbidities
Internal medicine physicians — frequently manage complex hypertension requiring combination therapy
Family medicine physicians — primary managers of hypertension in the general adult population
Nephrologists — for hypertension associated with chronic kidney disease (with renal function monitoring)
Nurse practitioners (NPs) and physician assistants (PAs) — with full prescribing authority in most states
Tribenzor can also be prescribed through telehealth platforms for established patients managing known hypertension. Because it is not a controlled substance, telehealth providers can send electronic prescriptions to any pharmacy without restriction. Telehealth platforms including Teladoc, MDLive, and Push Health have providers who prescribe blood pressure medications.
No. Tribenzor is not a controlled substance and has no DEA schedule. None of its three active ingredients — olmesartan, amlodipine, or hydrochlorothiazide — are controlled substances. This means Tribenzor can be prescribed by any licensed prescriber with prescription-writing authority, including physicians, nurse practitioners, and physician assistants.
Because it is not a controlled substance, Tribenzor prescriptions can be called in, faxed, or sent electronically to any pharmacy. Refills are not subject to the special restrictions that apply to Schedule II–V controlled substances. Telehealth prescribers can also prescribe Tribenzor and send it electronically without restrictions.
In clinical trials, the following side effects occurred in 2% or more of patients taking Tribenzor 40/10/25 mg:
Dizziness (most common reason for discontinuation)
Peripheral edema (ankle/leg swelling)
Headache
Fatigue
Nasopharyngitis (cold-like symptoms)
Muscle spasms
Nausea
Diarrhea
Urinary tract infections
Joint swelling
Fetal toxicity (boxed warning): Do not use during pregnancy; can cause injury or death to the developing fetus
Severe hypotension: Fainting, extreme dizziness, lightheadedness
Acute kidney injury: Reduced urine output, swelling; reported in 2.1% of Tribenzor patients in trials
Electrolyte imbalances: Low potassium, sodium, or magnesium from HCTZ component
Sprue-like enteropathy: Rare olmesartan side effect — severe chronic diarrhea with weight loss, can develop months to years after starting
Acute angle-closure glaucoma: Rare HCTZ reaction; sudden vision changes or eye pain require immediate ophthalmologic care
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Exforge HCT (amlodipine/valsartan/HCTZ)
Most similar triple combination; uses valsartan instead of olmesartan. Clinically comparable efficacy; follow-up BP check recommended after switching.
Component prescribing (generic olmesartan + amlodipine + HCTZ separately)
Same three drugs as separate tablets. Most cost-effective option (~$25–$50/month). Increases pill burden from 1 to 3 tablets.
Benicar HCT + amlodipine (olmesartan/HCTZ dual + separate CCB)
Keeps the same ARB and diuretic; adds amlodipine separately. Two pills instead of one, while preserving olmesartan.
Azor + HCTZ (amlodipine/olmesartan + separate diuretic)
Keeps the same ARB and CCB; adds HCTZ separately. Two pills instead of one. Generic amlodipine/olmesartan available.
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Aliskiren (in diabetic patients)
majorContraindicated in patients with diabetes; also avoid if GFR <60 mL/min. Increases risk of hypotension, hyperkalemia, and acute kidney failure.
Sparsentan (Filspari)
majorContraindicated; dual ARB therapy increases risk of hypotension, syncope, hyperkalemia, and acute kidney injury.
Lithium
majorHCTZ and olmesartan both reduce lithium clearance, increasing risk of lithium toxicity. Monitor lithium levels closely.
NSAIDs (ibuprofen, naproxen)
moderateReduces antihypertensive effect of both olmesartan and HCTZ; increases risk of renal impairment especially in elderly/volume-depleted patients.
Simvastatin
moderateAmlodipine increases simvastatin plasma concentrations; limit simvastatin to 20 mg/day when co-administered.
CYP3A4 inhibitors (diltiazem, ketoconazole)
moderateIncrease amlodipine exposure; monitor for increased amlodipine side effects (edema, hypotension).
Potassium-sparing diuretics (spironolactone, triamterene)
moderateOlmesartan raises potassium; combined with K-sparing diuretics risks dangerous hyperkalemia.
Cholestyramine/colestipol
moderateReduces HCTZ absorption by 43–85%; administer Tribenzor at least 4 hours before these drugs.
Antidiabetic drugs
moderateHCTZ may impair glucose tolerance; dosage adjustment of antidiabetics may be required. Monitor blood glucose.
Alcohol
minorPotentiates orthostatic hypotension; increased risk of dizziness and falls. Limit alcohol intake.
Tribenzor is an effective triple-combination blood pressure medication for patients who need more aggressive control than two-drug regimens provide. Combining olmesartan, amlodipine, and hydrochlorothiazide into a single daily tablet simplifies complex regimens and often improves adherence — which is one of the biggest challenges in long-term blood pressure management.
While Tribenzor is not in an FDA shortage, patients can still face stock gaps at individual pharmacies due to its multiple strengths and lower dispensing volume. Generic olmesartan/amlodipine/HCTZ with a discount card can bring costs as low as $36/month — and if finding your strength is the challenge, having a backup plan (component prescribing or Exforge HCT) ready can prevent dangerous medication gaps.
If you're having difficulty finding Tribenzor at your local pharmacy, medfinder can help. We call pharmacies near you to identify which ones have your specific Tribenzor strength in stock, then text you the results — so you spend less time on hold and more time taking care of your health.
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