Comprehensive medication guide to Trelegy including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$30–$75 copay; Tier 3–4 brand, prior authorization and step therapy typically required.
Estimated Cash Pricing
$580–$700 per inhaler (30-day supply) at retail; GSK savings card may reduce cost to $0 for eligible commercially insured patients.
Medfinder Findability Score
72/100
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Trelegy Ellipta is a once-daily triple combination inhaler made by GlaxoSmithKline (GSK). It contains three active ingredients — Fluticasone Furoate (an inhaled corticosteroid), Umeclidinium (a long-acting muscarinic antagonist), and Vilanterol (a long-acting beta2-agonist). It is FDA-approved for the maintenance treatment of COPD (including chronic bronchitis and emphysema) and for maintenance treatment of asthma in adults aged 18 and older. Trelegy is not intended for acute bronchospasm or rescue use.
Trelegy combines three mechanisms of action in a single inhaler:
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Together, these three components reduce inflammation, open the airways, and help patients breathe more easily with just one inhalation per day.
100/62.5/25 mcg
Fluticasone Furoate 100 mcg / Umeclidinium 62.5 mcg / Vilanterol 25 mcg (approved for COPD and asthma)
200/62.5/25 mcg
Fluticasone Furoate 200 mcg / Umeclidinium 62.5 mcg / Vilanterol 25 mcg (approved for asthma only)
Trelegy Ellipta is generally available at most pharmacies, earning a findability score of 72 out of 100. There is no formal FDA shortage listing as of early 2026. However, some patients report intermittent difficulty finding it in stock at local pharmacies due to high demand and supply chain variability. Insurance-related access barriers — including prior authorization and step therapy requirements — can also delay access. If your local pharmacy is out of stock, try checking larger chain pharmacies, specialty pharmacies, or using Medfinder to locate availability near you.
Trelegy is most commonly prescribed by:
Trelegy can also be prescribed via telehealth platforms that connect patients with qualified providers.
No. Trelegy Ellipta is not a controlled substance and has no DEA schedule. It does not have abuse potential and does not require special prescribing restrictions. However, it is a prescription-only medication and requires prior authorization from many insurance plans.
Rinsing your mouth with water after each use can help prevent thrush. Serious side effects may include pneumonia, paradoxical bronchospasm, cardiovascular effects, adrenal suppression, and glaucoma or cataracts with long-term use. Contact your doctor if you experience worsening breathing, chest pain, or signs of infection.
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Breztri Aerosphere
(Budesonide / Glycopyrrolate / Formoterol Fumarate) — Another triple combination ICS/LAMA/LABA inhaler, FDA-approved for COPD. Uses a metered-dose inhaler (MDI) device instead of dry powder.
Breo Ellipta
(Fluticasone Furoate / Vilanterol) — A dual ICS/LABA inhaler using the same Ellipta device. Suitable for patients who may not need triple therapy.
Anoro Ellipta
(Umeclidinium / Vilanterol) — A dual LAMA/LABA inhaler for COPD patients without a significant inflammatory component.
Symbicort
(Budesonide / Formoterol) — A widely used dual ICS/LABA inhaler available as a generic, often more affordable than Trelegy.
Prefer Trelegy? We can find it.
Strong CYP3A4 inhibitors
moderate(Ketoconazole, Itraconazole, Ritonavir, Clarithromycin, Cobicistat) — May increase Fluticasone and Vilanterol levels, raising the risk of side effects.
MAO inhibitors and tricyclic antidepressants
moderateMay potentiate cardiovascular effects of Vilanterol.
Beta-blockers
moderateMay block the bronchodilatory effects of Vilanterol. Avoid non-selective beta-blockers.
Other anticholinergic drugs
moderateAdditive anticholinergic effects with Umeclidinium.
Other long-acting beta-agonists (LABAs)
moderateDo not use with other LABA-containing products.
Non-potassium-sparing diuretics
moderateMay worsen hypokalemia and ECG changes.
Trelegy Ellipta is a convenient once-daily triple therapy inhaler that simplifies treatment for COPD and asthma patients who need all three medication classes. While the cash price of $580–$700 per inhaler is steep, GSK's savings card can reduce out-of-pocket costs to as little as $0 for eligible commercially insured patients. For uninsured patients, the GSK Patient Assistance Program (GSK For You) may provide the medication at no cost. No generic is currently available, with patent protection expected through the late 2020s. If you're having trouble finding Trelegy in stock, try using Medfinder to check availability at pharmacies near you.
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