Comprehensive medication guide to Os-Cal 500 With D including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0 with some Medicare Advantage OTC supplement benefits; generally not covered by standard Part D; some commercial plans cover it with a physician prescription for osteoporosis (M81.0) or hypocalcemia (E83.51) at a Tier 1–2 copay of $5–$15.
Estimated Cash Pricing
$9–$15 retail for brand-name Os-Cal 500 With D (75–160 count); as low as $2.51–$8.86 for generic calcium carbonate + Vitamin D3 with SingleCare or GoodRx discount cards for a 60-tablet package.
Medfinder Findability Score
82/100
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Os-Cal 500 With D is a brand-name over-the-counter dietary supplement that combines two essential bone health nutrients: calcium carbonate (500 mg per tablet) and cholecalciferol, also known as Vitamin D3. It is manufactured by Haleon, the global consumer healthcare company spun off from GlaxoSmithKline in July 2022.
Calcium carbonate is the most concentrated form of supplemental calcium, providing 40% elemental calcium by weight — meaning each 500 mg tablet delivers approximately 200 mg of usable calcium to the body. The Vitamin D3 component helps the body absorb and use that calcium effectively, making the combination significantly more beneficial for bone health than calcium alone.
Os-Cal 500 With D is available in multiple formulations: standard tablets, chewable tablets, and varying Vitamin D3 amounts (200 IU or 600 IU per tablet). It is sold OTC at most major pharmacy chains, grocery stores, warehouse retailers, and online without a prescription.
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When you take Os-Cal 500 With D with a meal, stomach acid dissolves the calcium carbonate tablet, releasing calcium ions. These ions move into the small intestine, where — facilitated by the Vitamin D3 in the supplement — they are transported across the intestinal lining into the bloodstream. Vitamin D3 is first processed by the liver, then by the kidneys into its active hormone form (calcitriol), which activates the proteins in intestinal cells responsible for absorbing calcium.
Once calcium enters the bloodstream, it is used in two critical ways: maintaining blood calcium levels that support nerve signaling, muscle contraction, and heart rhythm; and being deposited into bone tissue by osteoblasts (bone-building cells) as hydroxyapatite, the mineral compound that gives bones their density and strength.
A key limitation of calcium carbonate absorption is that the body can only absorb approximately 500 mg of elemental calcium per dose. Patients requiring more than 500 mg per day from supplements should split their dose — taking one tablet with breakfast and one with dinner — to maximize the amount actually absorbed and used by the body.
500 mg / 200 IU — tablet
Calcium carbonate 500 mg + Vitamin D3 200 IU — standard formulation
500 mg / 600 IU — tablet
Calcium carbonate 500 mg + Vitamin D3 600 IU — higher vitamin D version
500 mg / 600 IU — chewable tablet
Calcium carbonate 500 mg + Vitamin D3 600 IU — chewable formulation for those who prefer not to swallow tablets
Os-Cal 500 With D is generally widely available in the United States and is not on the FDA Drug Shortage list as of 2026. It carries a high findability score compared to most medications, reflecting that it is an OTC supplement manufactured by a major company (Haleon) with broad retail distribution. However, specific formulations — particularly the 160-count caplet or the higher-Vitamin D versions — can be inconsistently stocked at individual pharmacy locations due to seasonal demand surges, ordering cycle gaps, and SKU variability.
Patients who encounter empty shelves at their local pharmacy have several practical options: check online inventory tools at CVS, Walgreens, or Walmart; ask the pharmacist to place a special order (1–3 business days); purchase online through Amazon or Walmart.com; or ask for a generic equivalent (calcium carbonate 500 mg + Vitamin D3), which is almost always in stock under store-brand or generic labels at a lower price.
For the fastest way to find Os-Cal 500 With D near you without calling multiple pharmacies, use medfinder. medfinder contacts pharmacies in your area directly and texts you which ones have it in stock.
Os-Cal 500 With D is an over-the-counter supplement and does not require a prescription. However, many patients begin taking it based on recommendations from healthcare providers who conduct bone health evaluations, order DEXA scans, or identify low calcium or Vitamin D levels through blood tests. A wide range of provider types recommend this supplement:
Telehealth options are widely available for initial consultations and lab review related to calcium and Vitamin D supplementation. A DEXA scan for bone density assessment requires an in-person radiology visit, but pre- and post-scan consultations can typically be done via telehealth platforms such as Teladoc, MDLive, and others.
No. Os-Cal 500 With D (calcium carbonate + cholecalciferol/Vitamin D3) is not a controlled substance. It is classified as an over-the-counter dietary supplement and carries no DEA scheduling. It does not require a prescription, has no refill restrictions, and can be purchased in any quantity at any pharmacy, grocery store, or online retailer without physician authorization.
While a prescription is not required to purchase Os-Cal 500 With D, a healthcare provider's recommendation is still important for many patients — particularly to determine the correct dose, to check for drug interactions, and to confirm whether supplementation is appropriate given the patient's overall health status and dietary calcium intake.
Os-Cal 500 With D is generally well tolerated. The most common side effects are gastrointestinal and are related to the calcium carbonate component:
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Caltrate 600 + D3
Calcium carbonate 600 mg + Vitamin D3 800 IU — higher calcium and Vitamin D dose, same carbonate-based form as Os-Cal
Citracal + D (calcium citrate)
Calcium citrate with Vitamin D3 — better absorbed without food, preferred for patients on PPIs or H2 blockers
Viactiv Calcium Chews
Soft chew format with 650 mg calcium carbonate + 500 IU Vitamin D3; also contains Vitamin K (caution with anticoagulants)
Nature Made Calcium 600 + D3
USP-verified calcium carbonate 600 mg + Vitamin D3 400 IU; widely available and independently quality-tested
Prefer Os-Cal 500 With D? We can find it.
Bisphosphonates (alendronate, risedronate, ibandronate)
majorCalcium severely reduces bisphosphonate absorption. Separate by at least 30 minutes — take bisphosphonate first on empty stomach, then take Os-Cal with the subsequent meal.
Levothyroxine (Synthroid)
majorCalcium significantly reduces levothyroxine absorption. Separate by at least 4 hours.
Thiazide diuretics (hydrochlorothiazide, chlorthalidone)
majorThiazides reduce calcium excretion; combining with calcium supplements increases risk of hypercalcemia. Monitor blood calcium periodically.
Quinolone antibiotics (ciprofloxacin, levofloxacin)
moderateCalcium chelates quinolones, reducing antibiotic absorption by up to 50–90%. Separate by at least 2 hours before or 6 hours after.
Tetracycline antibiotics (doxycycline, minocycline)
moderateCalcium binds tetracyclines, reducing absorption. Separate by at least 2–3 hours.
Iron supplements
moderateCalcium can reduce iron absorption. Separate by at least 2 hours.
Bile acid sequestrants (cholestyramine, colestipol)
moderateCan reduce Vitamin D absorption from the supplement. Separate by at least 4 hours.
Orlistat (Xenical, Alli)
minorBlocks fat absorption, may reduce Vitamin D (fat-soluble) absorption. Take multivitamin/D separately if on orlistat.
Os-Cal 500 With D is a foundational supplement for bone health — simple in concept but important to use correctly. Taking it with food, splitting doses throughout the day, separating it from interacting medications (particularly bisphosphonates, levothyroxine, and certain antibiotics), and not exceeding daily calcium limits are all critical to getting maximum benefit and avoiding side effects.
It's also worth knowing that generics are just as effective as brand-name Os-Cal 500 With D — and often significantly less expensive. Look for calcium carbonate 500 mg + Vitamin D3 store-brand supplements at your pharmacy, which contain the same active ingredients at 30–50% lower cost.
If you're struggling to find Os-Cal 500 With D at your local pharmacy, medfinder can help. medfinder contacts nearby pharmacies on your behalf to find which ones have it in stock, then texts you the results. It's a fast, convenient way to locate any medication or supplement near you.
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Real-time availability
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