Comprehensive medication guide to Methscopolamine including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$10–$50 copay for generic when covered; Tier 2–3 on most commercial plans that include it; Medicare Part D coverage is plan-specific — check your formulary. No manufacturer savings program is available.
Estimated Cash Pricing
$150–$185 retail for generic methscopolamine bromide; as low as $45–$48 with GoodRx or SingleCare coupons for a 30-day supply.
Medfinder Findability Score
62/100
On this page
Methscopolamine bromide is a prescription anticholinergic medication used as adjunctive therapy for peptic ulcer disease in adults. It is a quaternary ammonium derivative of scopolamine — chemically modified to act primarily in the peripheral nervous system (especially the GI tract) rather than crossing into the brain.
The brand-name versions Pamine and Pamine Forte have been discontinued. Generic methscopolamine bromide tablets (2.5 mg and 5 mg) remain available from a limited number of manufacturers. It is taken orally 30 minutes before meals and at bedtime.
Methscopolamine is also used as a drying agent in combination cold and allergy products (combined with antihistamines and decongestants). It is not a controlled substance and can be prescribed by any licensed provider.
We have a 99% success rate finding medications, even during nationwide shortages.
Need this medication?
Methscopolamine is a muscarinic acetylcholine receptor antagonist. It blocks muscarinic receptors in the gastrointestinal tract, preventing acetylcholine from activating them. This produces several effects that reduce ulcer symptoms:
Reduces the volume and total acid content of gastric secretion
Inhibits gastrointestinal motility (slows gut movement and cramping)
Inhibits salivary secretion
Because it is a quaternary ammonium compound (permanently charged), methscopolamine does not easily cross the blood-brain barrier. This distinguishes it from scopolamine, which readily enters the brain and causes CNS side effects like confusion and drowsiness. Methscopolamine's peripheral selectivity makes it a more targeted GI agent, though it still affects other peripheral organs with muscarinic receptors (eyes, sweat glands, bladder, heart).
Importantly, the FDA prescribing information notes that methscopolamine has not been shown to heal peptic ulcers, prevent recurrence, or prevent complications. It provides symptomatic relief as an adjunct to primary treatment.
2.5 mg — tablet
Standard starting dose; taken 30 minutes before each of 3 meals and optionally at bedtime
5 mg — tablet
Higher dose for severe symptoms; taken 30 minutes before meals and at bedtime (20 mg/day total)
Methscopolamine is not on the FDA's Drug Shortage Database in 2026, but it can still be difficult to find at many retail pharmacies. The discontinuation of the brand-name Pamine and a significant decline in prescribing volume means many chain pharmacies simply don't keep it in stock. Independent pharmacies and mail-order services are often more reliable sources.
Most pharmacies can special-order methscopolamine bromide within 1-2 business days if you request it ahead of time. Always call ahead before making a trip to the pharmacy. If your usual pharmacy cannot reliably supply it, consider transferring your prescription to an independent pharmacy or using your insurance plan's mail-order service for a 90-day supply.
For the fastest way to find methscopolamine in stock near you, use medfinder — a service that contacts pharmacies in your area to check which ones can fill your prescription, then texts you the results.
Methscopolamine bromide is not a controlled substance, so it can be prescribed by any licensed healthcare provider without special DEA registration requirements. There are no state-level restrictions specific to this drug.
Gastroenterologists
Primary care physicians (family medicine, internal medicine)
Internists
Nurse practitioners (NPs), subject to state prescribing authority
Physician assistants (PAs), subject to state prescribing authority
Because methscopolamine is not a controlled substance, it can be prescribed via telehealth without requiring a prior in-person visit. This makes it accessible through telemedicine platforms for patients who have difficulty getting an in-person GI appointment.
No. Methscopolamine bromide is not a controlled substance and has no DEA scheduling classification. It does not have abuse potential in the way that narcotics, stimulants, or sedatives do. This means:
Any licensed prescriber can write a methscopolamine prescription without special DEA registration.
It can be prescribed via telehealth without requiring an in-person visit.
It can be called in, faxed, or e-prescribed to any pharmacy without restriction.
There are no regulatory limits on the number of refills (though your doctor may set clinical follow-up requirements).
This is in contrast to scopolamine (Transderm Scop), which is also not scheduled, but methscopolamine is frequently confused with it. The two drugs are different products with different uses and formulations.
Dry mouth (xerostomia)
Blurry vision and dry eyes
Drowsiness and fatigue
Dizziness (especially when standing)
Constipation
Decreased sweating (risk of overheating)
Headache
Nausea, bloating, change in taste
Insomnia or anxiety
Severe allergic reaction (rash, swelling, difficulty breathing)
Fast or irregular heartbeat (tachycardia)
Inability to urinate (urinary retention)
Heat stroke symptoms (no sweating, confusion, high temperature)
Diarrhea (possible sign of intestinal blockage — stop drug and call doctor)
Confusion or delirium (especially in elderly patients)
Know what you need? Skip the search.
Hyoscyamine (Levsin)
Anticholinergic antispasmodic in the same drug class; more widely available; used for IBS and GI cramping
Dicyclomine (Bentyl)
Anticholinergic antispasmodic used for IBS and bowel spasms; available as capsule and liquid; easier to find than methscopolamine
Glycopyrrolate (Robinul)
Quaternary ammonium anticholinergic structurally similar to methscopolamine; used for peptic ulcer and hyperhidrosis
Omeprazole (Prilosec)
Proton pump inhibitor; the preferred first-line treatment for peptic ulcer healing; available OTC and by prescription
Famotidine (Pepcid)
H2 receptor blocker; effective for acid suppression; available OTC; widely stocked at all pharmacies
Prefer Methscopolamine? We can find it.
Pramlintide (Symlin)
majorContraindicated — synergistic inhibition of GI motility can cause dangerous gut slowing (paralytic ileus)
Other anticholinergics (scopolamine, oxybutynin, antihistamines, bladder medications)
majorAdditive anticholinergic toxicity — severe dry mouth, urinary retention, constipation, confusion, heat stroke risk
Tricyclic antidepressants (amitriptyline, nortriptyline)
moderateAdditive anticholinergic effects; monitor for dry mouth, urinary retention, constipation, confusion
Antipsychotics (quetiapine, aripiprazole, loxapine)
moderateAdditive anticholinergic effects; methscopolamine may reduce GI absorption of some antipsychotics
Opioids and CNS depressants
moderateEnhanced sedation; increased risk of constipation and urinary retention
Botulinum toxin products
moderatePotentiates neuromuscular weakness and systemic anticholinergic effects
Aluminum hydroxide antacids
moderateDecreases oral absorption of methscopolamine; separate doses by at least 2 hours
Cholinesterase inhibitors (donepezil, galantamine, rivastigmine)
moderatePharmacodynamic antagonism — opposes the mechanism of Alzheimer's medications; may reduce effectiveness of both drugs
Methscopolamine bromide remains a legitimate medication option for patients with peptic ulcer symptoms who benefit from anticholinergic antispasmodic therapy. While newer drug classes have largely replaced it as primary ulcer treatment, it continues to serve a role for some patients in 2026. The biggest practical challenges are availability (pharmacies often don't stock it routinely) and cost (retail price around $150-$185 without discounts, dropping to $45-$48 with GoodRx or SingleCare).
If you've been prescribed methscopolamine, plan ahead for refills — start looking 7-10 days before you run out. Independent pharmacies and mail-order services are your most reliable sources. Always discuss with your doctor if availability becomes a recurring barrier, as there are effective and widely available alternatives.
To find methscopolamine at a pharmacy near you, use medfinder — enter your medication, dosage, and zip code, and medfinder contacts local pharmacies on your behalf to identify who can fill your prescription.
Medfinder Editorial Standards
Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
Real-time availability
Medfinder is actively checking pharmacy inventory for Methscopolamine. We don't publish a number until we have enough verified pharmacy checks to be accurate — start a search and our team confirms current availability near you, usually within 24 hours.
ChatGPT
Claude
Gemini