Comprehensive medication guide to Gynazole-1 including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$25–$60 copay depending on plan tier; some commercial plans cover it while others require prior authorization. Medicare generally does not cover Gynazole-1. The manufacturer savings card can bring the cost down to $25 for commercially insured patients.
Estimated Cash Pricing
Retail price is approximately $165–$169 per single-dose applicator; as low as $94.33 with a GoodRx coupon or $112 with SingleCare. The Padagis savings program can reduce cost to $25 for commercially insured patients.
Medfinder Findability Score
60/100
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Gynazole-1 is the brand name for butoconazole nitrate 2% vaginal cream, USP — a single-dose prescription antifungal medication used to treat vaginal yeast infections. The "1" in its name refers to its single-dose format: one pre-filled disposable applicator delivers the full 5-gram dose (100 mg of butoconazole nitrate) intravaginally.
Gynazole-1 is FDA-approved for the local treatment of vulvovaginal candidiasis (VVC) — vaginal yeast infections caused by Candida species. It is manufactured by Padagis (formerly Perrigo) and is available only by prescription. As of 2026, there is no FDA-approved generic version.
Butoconazole nitrate belongs to the imidazole class of antifungals. It works by disrupting the fungal cell membrane, leading to the death or growth inhibition of Candida organisms causing the infection.
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Butoconazole nitrate is an imidazole antifungal that targets the fungal cell membrane. It works by inhibiting the conversion of lanosterol to ergosterol — a critical step in building the fungal cell wall. Ergosterol is the structural equivalent of cholesterol in human cells; without it, the fungal cell membrane loses structural integrity.
When ergosterol production is blocked, the fungal cell membrane becomes leaky and abnormal. Essential cellular contents escape, leading to osmotic disruption or growth inhibition of the fungal cell. In laboratory studies, butoconazole has demonstrated both fungicidal (kills fungi) and fungistatic (stops growth) activity against Candida species, including Candida albicans.
Gynazole-1's bioadhesive formulation allows it to remain in vaginal tissue for approximately 4 days after a single application, providing extended antifungal activity without the need for repeat dosing. Only about 1.7% of the applied dose is absorbed systemically, which accounts for its minimal systemic side effect profile.
2% — Vaginal cream, single-dose prefilled applicator (5g)
One applicatorful (100 mg butoconazole nitrate) inserted intravaginally as a single dose, typically at bedtime
Gynazole-1 can be moderately difficult to find at local pharmacies. While there is no active FDA shortage as of 2026, it is a brand-name-only medication with no generic equivalent, and pharmacies stock it less frequently than OTC antifungals. Patients commonly report needing to check multiple pharmacies before finding it available.
The primary drivers of its limited availability are its brand-name-only status (no generic to drive volume), its relatively high retail price ($165–$169), inconsistent insurance coverage, and competition from lower-cost OTC alternatives. Most pharmacies can special-order Gynazole-1 within 1–2 business days if it is not currently in stock.
If you're having trouble locating Gynazole-1, medfinder can call pharmacies in your area on your behalf to find which ones have it in stock — and text you the results.
Because Gynazole-1 is not a controlled substance, it can be prescribed by any licensed healthcare provider with prescribing authority. There are no special DEA registration requirements or prescriber restrictions associated with this medication.
Healthcare providers who commonly prescribe Gynazole-1 include:
Gynazole-1 can also be prescribed via telehealth. Since it is not a controlled substance, no prior in-person visit is required. Telehealth platforms offering women's health services can prescribe butoconazole after a virtual consultation.
No. Gynazole-1 (butoconazole nitrate) is not a controlled substance and is not scheduled by the DEA. It is a prescription-only medication, but there are no special requirements for how it can be prescribed — it can be prescribed via telehealth without a prior in-person visit, and there are no restrictions on the number of refills a prescriber can authorize.
Patients do not need to present a photo ID to fill Gynazole-1 at the pharmacy, and pharmacies do not face the same reporting or tracking requirements they would for controlled substances. However, a valid prescription from a licensed healthcare provider is required.
Gynazole-1 is generally well-tolerated. In controlled clinical trials of 314 patients, 5.7% reported adverse events, with only 1% considered treatment-related. Common side effects include:
Important warning: Gynazole-1 contains mineral oil, which can weaken latex condoms and vaginal diaphragms. Do not use latex contraceptive products for 72 hours after treatment. Serious side effects, including allergic reactions, are rare but require immediate medical attention.
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Miconazole (Monistat)
OTC imidazole antifungal available in 1-, 3-, and 7-day vaginal cream and suppository formats. Most widely stocked option for vaginal yeast infections. $15–$25 OTC.
Clotrimazole (Gyne-Lotrimin)
OTC imidazole antifungal available as 3- and 7-day vaginal cream. First-line OTC option per CDC guidelines. $10–$20 OTC.
Terconazole (Terazol)
Prescription triazole antifungal available as 3- or 7-day vaginal cream or suppository. Generic available. Good alternative for non-albicans Candida. ~$30–$80 with coupon.
Fluconazole (Diflucan)
Oral prescription triazole taken as a single 150 mg tablet. Widely available generic at $5–$20 with coupon. Avoid in pregnancy. Most convenient prescription oral option.
Tioconazole (Vagistat-1)
OTC single-dose intravaginal ointment (6.5%). Similar single-dose convenience as Gynazole-1 at a lower OTC price. $15–$25.
Prefer Gynazole-1? We can find it.
Latex condoms and diaphragms
moderateMineral oil in Gynazole-1 can weaken latex or rubber contraceptive devices. Do not rely on latex condoms or vaginal diaphragms for 72 hours after application.
Warfarin (Coumadin)
minorLow risk with topical use due to minimal systemic absorption (~1.7% of dose). However, imidazoles as a class can inhibit CYP2C9, potentially affecting warfarin metabolism. Inform provider if taking warfarin; INR monitoring may be warranted.
Other intravaginal products
minorAvoid using other intravaginal creams, suppositories, or douches simultaneously. Combination may reduce efficacy or cause additional irritation.
Gynazole-1 is a clinically effective, FDA-approved single-dose treatment for vaginal yeast infections. Its bioadhesive single-dose format is a significant convenience advantage over multi-day OTC regimens, and it is a legitimate first-line option for uncomplicated VVC in non-pregnant women. However, its brand-name-only status, relatively high retail price, and inconsistent pharmacy stocking make it a medication that requires some proactive planning to fill.
Patients can significantly reduce their out-of-pocket costs through the Padagis savings program (as low as $25 for commercially insured patients), GoodRx ($94+), or SingleCare ($112+). When pharmacies don't have it in stock, most can special-order it within 1–2 business days, or a clinical alternative like fluconazole or terconazole may be appropriate.
If you're having trouble finding Gynazole-1 at a pharmacy near you, medfinder can call pharmacies in your area on your behalf and text you which ones have it in stock — saving you the time and frustration of calling pharmacies yourself.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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