What Is Gynazole-1? Uses, Dosage, and What You Need to Know in 2026

Gynazole-1 is a prescription antifungal vaginal cream used to treat vaginal yeast infections. Its convenience — a single-dose application — sets it apart from multi-day OTC alternatives. Here's everything you need to know about Gynazole-1, including what it is, what it treats, how to use it correctly, and what to expect.

What Is Gynazole-1?

Gynazole-1 is the brand name for butoconazole nitrate 2% vaginal cream, USP. It is an imidazole antifungal medication formulated specifically for intravaginal use. The "1" in the name refers to its single-dose format: the entire dose (approximately 5 grams of cream containing 100 mg of butoconazole nitrate) is delivered in a single pre-filled disposable applicator.

Gynazole-1 is manufactured by Padagis (formerly Perrigo) and is dispensed only by prescription. There is no FDA-approved generic version as of 2026. It is not a controlled substance.

What Does Gynazole-1 Treat?

Gynazole-1 is FDA-approved for the local treatment of vulvovaginal candidiasis (VVC) — the medical term for vaginal yeast infections caused by Candida species. It has been clinically demonstrated to be effective against infections caused by Candida albicans, which is responsible for the majority of vaginal yeast infections.

Common symptoms of vulvovaginal candidiasis that Gynazole-1 treats include:

• Vaginal itching and irritation
• Vaginal burning, especially during urination or sex
• Thick, white, odorless vaginal discharge (cottage cheese-like consistency)
• Vulvar redness and swelling

Gynazole-1 Dosage and How to Use It

The recommended dose of Gynazole-1 is:

One applicatorful (approximately 5 grams of cream, 100 mg butoconazole nitrate) inserted intravaginally as a single dose. It is typically administered at bedtime.

How to use the applicator correctly:

1. Wash your hands thoroughly before handling the applicator
2. Lie on your back with knees drawn upward and spread apart
3. Gently insert the applicator high into the vagina (unless you are pregnant — in that case insert gently and do not force it)
4. Push the plunger to release the full dose of cream
5. Remove the applicator and discard it (it is a single-use, disposable applicator)
6. Wash your hands again afterward

What to Expect After Using Gynazole-1

Most patients begin feeling relief from symptoms within 24 hours of a single application. The bioadhesive formulation is designed to remain in the vaginal tissue for approximately 4 days after application, providing sustained antifungal activity without the need for multiple doses.

If you do not feel better within 4 days, contact your healthcare provider. You may have a different type of infection or a less common Candida species that requires a different treatment.

Is Gynazole-1 Safe in Pregnancy?

The safety and effectiveness of Gynazole-1 in pregnant women has not been established in adequate and well-controlled studies. The prescribing information states it should be used during pregnancy only when the potential benefit justifies the potential risk to the fetus. If you are pregnant, use the vaginal applicator extra gently and follow your doctor's instructions closely.

Key Facts at a Glance

Brand name: Gynazole-1

Generic name: Butoconazole nitrate 2% vaginal cream

Drug class: Imidazole antifungal

Indication: Vulvovaginal candidiasis (vaginal yeast infections)

Dosage form: Single-dose prefilled vaginal applicator (5g cream, 100mg butoconazole nitrate)

Manufacturer: Padagis (formerly Perrigo)

Controlled substance: No

Generic available: No (brand-name only as of 2026)

Retail price: ~$165–$169 (savings programs and coupons can significantly reduce this)

Bottom Line

Gynazole-1 is a single-dose prescription antifungal cream that offers a convenient, evidence-based treatment for vaginal yeast infections. It requires a prescription and can be challenging to find at some pharmacies due to its brand-name-only status. Want to understand how it works at a biological level? Read our guide on how Gynazole-1 works. Having trouble finding it? medfinder can help you locate a pharmacy that has it in stock.