Comprehensive medication guide to {drug} including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Desvenlafaxine XR is a serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressant approved by the FDA for the treatment of major depressive disorder (MDD). It is the active metabolite of venlafaxine (Effexor XR). Brand-name versions include Pristiq, Khedezla, Desfax, and Ellefore. Generic versions are widely available and significantly more affordable.
In addition to depression, Desvenlafaxine XR is sometimes prescribed off-label for menopausal hot flashes, generalized anxiety disorder, neuropathic pain, and fibromyalgia.
Desvenlafaxine XR works by blocking the reuptake of two key neurotransmitters in the brain: serotonin and norepinephrine. By preventing these chemicals from being reabsorbed, more serotonin and norepinephrine remain available in the brain, which helps improve mood, energy, and overall sense of well-being. The extended-release formulation allows for once-daily dosing, providing steady medication levels throughout the day.
Desvenlafaxine XR is available as both desvenlafaxine succinate ER and desvenlafaxine fumarate ER (Khedezla) formulations.
Desvenlafaxine XR is generally available at most pharmacies in 2026. It is not currently listed on the FDA Drug Shortage database. Generic versions from multiple manufacturers are widely stocked, especially the 50 mg strength. However, less common strengths (25 mg and 100 mg) may occasionally experience intermittent supply disruptions from specific generic manufacturers. If your pharmacy is out of stock, Medfinder can help you locate it nearby.
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Desvenlafaxine XR can be prescribed by a range of healthcare providers, including:
Desvenlafaxine XR is also available through telehealth platforms, making it convenient to obtain a prescription remotely.
No, Desvenlafaxine XR is not a controlled substance. It is not classified under any DEA schedule. However, it should not be stopped abruptly — gradual tapering under medical supervision is recommended to avoid discontinuation syndrome, which can include dizziness, nausea, headache, and irritability.
Important: Desvenlafaxine XR carries a boxed warning about increased risk of suicidal thoughts and behavior in children, adolescents, and young adults under 25. Monitor closely during the first few months of treatment or dose changes. Contact your doctor immediately if you experience worsening depression or unusual mood changes.
If Desvenlafaxine XR is unavailable or not the right fit, your doctor may consider these alternatives:
Always consult your healthcare provider before switching medications.
Desvenlafaxine XR has several important drug interactions to be aware of:
Always inform your doctor and pharmacist of all medications and supplements you are taking.
Desvenlafaxine XR is a widely available and affordable SNRI antidepressant that is generally easy to find at most pharmacies in 2026. With multiple generic manufacturers producing the medication, most patients should have little difficulty obtaining it — especially at the standard 50 mg dose. If you're having trouble finding Desvenlafaxine XR at your local pharmacy, try using Medfinder to check availability near you. Discount cards from GoodRx or SingleCare can bring the cash price down to as low as $15 per month for the generic version.
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