Comprehensive medication guide to Collagenase including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$75/month
Estimated Cash Pricing
$333–$7,222/month
Medfinder Findability Score
55/100
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Collagenase is an enzymatic medication derived from the bacterium Clostridium histolyticum. It is available in two formulations for different medical uses:
Santyl (topical ointment) is used for the debridement of chronic dermal ulcers and severely burned areas. It helps remove dead tissue from wounds while preserving healthy tissue, promoting natural healing.
Xiaflex (injectable) is used to treat Dupuytren's contracture (a condition where thickened tissue in the hand causes fingers to curl inward) and Peyronie's disease (a condition involving penile curvature caused by collagen plaques).
Santyl topical ointment — topical
250 units/g, available in 30g and 90g tubes
![Why Is Collagenase So Hard to Find? [Explained for 2026]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2Fcc42dc907bba07c959e47a77ba0244018b849178-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
![How to Find a Doctor Who Can Prescribe Collagenase Near You [2026 Guide]](/_next/image?url=https%3A%2F%2Fcdn.sanity.io%2Fimages%2Fvur4atr4%2Fproduction%2Fd6435a99057f3e507bfeeb411f76f71db146cf82-1024x1024.png%3Frect%3D0%2C256%2C1024%2C512%26w%3D400%26h%3D200%26auto%3Dformat&w=828&q=75)
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Xiaflex injectable powder — powder
0.9 mg per vial (reconstituted before use by healthcare provider)
Serious side effects can include tendon rupture, ligament damage, and nerve injury (Dupuytren's) or corporal rupture and severe hematoma (Peyronie's). Xiaflex for Peyronie's disease carries a boxed warning about corporal rupture. Contact your healthcare provider immediately if you experience any severe symptoms.
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Medihoney
(medical-grade honey) — provides autolytic and osmotic debridement for wounds
Hydrogel dressings
(e.g., IntraSite Gel, Purilon Gel) — autolytic debridement alternative
NexoBrid
(anacaulase-bcdb) — enzymatic debridement agent for burns using concentrate of proteolytic enzymes enriched in bromelain
Surgical/sharp debridement
manual removal of necrotic tissue by a healthcare provider
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Povidone-iodine (Betadine)
moderateinactivates the collagenase enzyme; do not use together
Silver sulfadiazine
moderatemay reduce enzymatic activity of Collagenase
Metal-ion-containing products
moderate(aluminum, lead, silver, mercury) — inactivate collagenase
Hexachlorophene
moderatedecreases collagenase activity
Anticoagulants
moderate(warfarin, heparin) — increased bleeding risk when used with Xiaflex injections
Other topical wound care products
moderatemay interfere with Santyl activity if applied simultaneously
Acidic wound dressings/solutions
moderateCollagenase works optimally at pH 6–8; acidic products may reduce effectiveness
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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