What Is Analpram HC? Uses, Dosage, and What You Need to Know in 2026

Analpram HC is a prescription combination topical medication used to relieve pain, itching, swelling, and inflammation in the anorectal area and on the skin. If you've been prescribed Analpram HC — or want to understand this medication better — this guide covers everything you need to know.

What Is Analpram HC?

Analpram HC is a brand-name prescription medication made by Sebela Pharmaceuticals (distributed by Legacy Pharma). It is a topical combination product containing two active ingredients:

Hydrocortisone acetate (2.5% or 1%): A low-potency corticosteroid that reduces inflammation, swelling, and itching by suppressing the inflammatory response in the skin

Pramoxine hydrochloride (1%): A topical local anesthetic that temporarily numbs the area, providing rapid relief from pain and itching — often in as little as 2 to 5 minutes

This dual-action formula makes Analpram HC particularly effective for conditions where both inflammation and pain relief are needed simultaneously.

What Is Analpram HC Used For?

Analpram HC is used to treat a range of conditions affecting the anorectal area and the skin:

Hemorrhoids: External and internal hemorrhoids causing pain, itching, swelling, and burning — one of the most common indications for this medication

Anal fissures: Small tears in the lining of the anus causing pain and discomfort

Anorectal irritation and pruritus ani: Itching and irritation of the perianal skin

Skin conditions (topical cream form): Eczema (atopic dermatitis), psoriasis, contact dermatitis, insect bites, minor burns, and other corticosteroid-responsive dermatoses

Available Forms and Strengths

Analpram HC is available in multiple formulations:

Cream: 1%/1% and 2.5%/1% (most common; 1 oz tube with multi-port applicator for anorectal use)

Lotion: 1%/1% and 2.5%/1% (2 fl oz bottle)

Foam (Epifoam/Proctofoam HC): 1%/1% (pressurized canister for rectal use)

Advanced Kits: Cream in single-use 4g tubes (treat-and-toss convenience)

Dosage and How to Use Analpram HC

Always follow your doctor's specific instructions. General dosing guidance for Analpram HC is:

Frequency: Apply 3 to 4 times daily (or every 6 to 8 hours depending on severity) to the affected area

Amount: Apply as a thin film to the affected area; use the smallest amount that provides relief

Preparation: Clean the affected area with mild soap and water, rinse, and pat dry before applying

Handwashing: Wash hands before and after applying the cream, unless treating a hand condition

Duration: Do not use longer than directed by your doctor; discontinue if no improvement after 2–3 weeks or if symptoms worsen

Important Safety Information

Before using Analpram HC, tell your doctor about:

Any allergies to hydrocortisone, pramoxine, or other local anesthetics

Any current skin infections (bacterial, fungal, or viral) — Analpram HC should not be used on infected skin

Whether you are pregnant, breastfeeding, or planning to become pregnant

Any history of diabetes, immune suppression, or adrenal disorders

Avoid using Analpram HC on your face (unless directed), in your eyes, ears, or nose, or on broken or infected skin. Do not cover the treated area with an occlusive bandage unless instructed by your doctor.

Is There a Generic Version?

Yes. Generic hydrocortisone-pramoxine topical is widely available and therapeutically equivalent to brand-name Analpram HC. It's more widely stocked at pharmacies and significantly less expensive — often as low as $40–$41 with a GoodRx coupon compared to $150–$390 for the brand.

To learn more about how Analpram HC works at the molecular level, see: How Does Analpram HC Work? Mechanism of Action Explained.

If you need help locating Analpram HC at a pharmacy near you, medfinder can call pharmacies on your behalf and text you the results.