Comprehensive medication guide to Alfuzosin XR including estimated pricing, availability information, side effects, and how to find it in stock at your local pharmacy.
Estimated Insurance Pricing
$0–$30 copay for generic alfuzosin on most commercial plans (Tier 1–2); Medicare Part D typically lists it at Tier 1 with copays of $0–$10. Quantity limits may apply.
Estimated Cash Pricing
$40–$115 retail for a 30-day supply of generic alfuzosin ER 10 mg; as low as $8–$12 with GoodRx or SingleCare discount coupons. Brand-name Uroxatral can exceed $1,000/month.
Medfinder Findability Score
72/100
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Alfuzosin XR (alfuzosin hydrochloride extended-release) is a prescription alpha-1 adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH) — an enlarged prostate — in adult men. It is the generic equivalent of the brand-name drug Uroxatral, which was first approved by the FDA in 2003.
Alfuzosin XR is available as a 10 mg extended-release tablet taken once daily with food. It is not approved for women, children, or as a treatment for hypertension. It is not a controlled substance and does not require any special prescription handling.
BPH affects roughly half of all men in their 50s and up to 90% of men in their 80s. Alpha-blockers like Alfuzosin XR are among the most widely prescribed medications in urology, offering rapid symptom relief for the majority of patients who take them.
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Alfuzosin XR works by selectively blocking alpha-1A adrenergic receptors in the smooth muscle of the prostate, bladder neck, and urethra. Alpha-1A receptors are abundant in these tissues and, when activated by adrenaline and related chemicals, cause the smooth muscle to contract — tightening the urethral passage and worsening BPH symptoms.
By blocking these receptors, alfuzosin causes the smooth muscle to relax, widening the urethra and allowing urine to flow more freely. This directly addresses the dynamic component of BPH obstruction — the muscle tension — without affecting the static component (prostate size). Alfuzosin does not shrink the prostate.
The extended-release matrix in each tablet ensures the medication is absorbed gradually over 24 hours, providing steady drug levels and once-daily dosing without requiring dose titration. Food significantly improves absorption — bioavailability is approximately 50% lower when taken on an empty stomach.
10 mg — extended-release tablet
Once daily with food; do not crush or chew
As of 2026, Alfuzosin XR is not listed on the FDA's official drug shortage database, and generic alfuzosin hydrochloride extended-release is produced by multiple manufacturers. Most patients can fill their prescription without difficulty at major retail pharmacies. However, localized stock gaps occur periodically due to wholesaler allocation cycles, manufacturer transitions, and the complexity of extended-release formulation manufacturing.
If your pharmacy is out of stock, try calling multiple pharmacies or use medfinder — a paid service that calls pharmacies near you to identify which ones have your medication in stock, then texts you the results.
Mail-order pharmacies such as Cost Plus Drugs and Amazon Pharmacy generally maintain more reliable inventory of generic medications. Patients who fill 90-day supplies via mail-order are less likely to experience stock gaps at refill time.
Alfuzosin XR is not a controlled substance, so any licensed prescriber with a valid DEA registration can prescribe it without additional licensing requirements. A urology specialist referral is not required for BPH treatment, and most men receive their initial prescription from their primary care physician.
Urologists (most commonly for moderate-severe BPH or specialist follow-up)
Primary care physicians (family medicine, internal medicine)
Geriatricians
Nurse practitioners (NPs) and physician assistants (PAs) — in all 50 states
Men's health specialists
Alfuzosin XR is available via telehealth for patients with an established BPH diagnosis. Telehealth platforms including Teladoc, MDLive, and Ro (Roman) can provide prescription refills without an in-person visit once the diagnosis is established. Initial diagnosis may still require an in-person exam, including a digital rectal exam and PSA test.
No. Alfuzosin XR (alfuzosin hydrochloride extended-release) is not a controlled substance and is not scheduled by the DEA. It can be prescribed by any licensed prescriber without special DEA registration or controlled substance protocols.
Because alfuzosin XR is not controlled, prescriptions can be written for up to a 90-day supply, refills can be authorized by telephone or electronically, and the prescription can be transferred between pharmacies without restriction. Stopping alfuzosin XR abruptly does not cause dangerous withdrawal, though BPH urinary symptoms may return temporarily.
The following side effects occurred in 2% or more of patients in clinical trials and more often than placebo:
Dizziness (6%)
Upper respiratory tract infection (3%)
Headache (3%)
Fatigue (3%)
Nausea and abdominal pain (1-2%)
Orthostatic hypotension: Significant blood pressure drop when standing; most likely in first few hours after dose or with antihypertensive co-medications
QT prolongation: May prolong the QT interval; use with caution in patients with history of QT prolongation or taking QT-prolonging drugs
Angina: Discontinue if new or worsening chest pain occurs
Priapism: Rare (<1 in 50,000); requires emergency treatment if erection persists >2-4 hours
IFIS: Intraoperative Floppy Iris Syndrome during cataract surgery — inform ophthalmologist of alpha-blocker use
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Tamsulosin (Flomax)
Most prescribed alpha-blocker for BPH; first-line in most guidelines; very affordable generic ($4-15/month with coupons); higher rate of ejaculatory side effects (8-18%) than alfuzosin
Silodosin (Rapaflo)
Most uroselective alpha-1A blocker; minimal blood pressure effect; highest ejaculatory side effect rate (>20%); generic available at $30-80/month with coupons
Doxazosin (Cardura)
Non-selective alpha-blocker for BPH and hypertension; dose titration required; very affordable ($1-8/month generic); higher orthostatic hypotension risk
Finasteride (Proscar)
5-alpha reductase inhibitor that shrinks the prostate over 3-6 months; best for large prostates; often combined with alpha-blockers; $5-30/month generic
Prefer Alfuzosin XR? We can find it.
Ketoconazole / Itraconazole (antifungals)
majorPotent CYP3A4 inhibitors — CONTRAINDICATED. Increase alfuzosin blood levels 2-3x, dramatically increasing hypotension and QT prolongation risk.
Ritonavir / Cobicistat / HIV protease inhibitors
majorPotent CYP3A4 inhibitors — CONTRAINDICATED. All boosted HIV antiretrovirals should be reviewed before prescribing alfuzosin.
Other alpha-1 blockers (tamsulosin, silodosin, doxazosin, terazosin)
majorCONTRAINDICATED — do not combine. Additive blood pressure lowering with significantly increased hypotension and syncope risk, no added benefit.
PDE5 inhibitors (sildenafil, tadalafil, vardenafil)
moderateBoth drug classes are vasodilators. Combination can cause clinically significant hypotension. Use with caution; separate dosing times; start PDE5 inhibitor at lowest dose.
Antihypertensives and diuretics
moderateAdditive blood pressure lowering. Monitor BP when starting alfuzosin in patients on antihypertensive therapy. Dose adjustments may be necessary.
QT-prolonging drugs (amiodarone, azithromycin, haloperidol, methadone)
moderateAlfuzosin can prolong the QT interval. Additive QT prolongation risk with other QT-prolonging agents. Use with caution and ECG monitoring.
Grapefruit juice
minorInhibits intestinal CYP3A4, raising alfuzosin blood levels unpredictably. Avoid grapefruit and grapefruit juice while taking alfuzosin.
Alfuzosin XR (alfuzosin hydrochloride extended-release 10 mg) is a well-established, effective alpha-blocker for BPH with a strong safety profile and a distinctive advantage over other agents in its class: a very low rate of ejaculatory side effects (approximately 1-3%). For sexually active men managing BPH, this makes alfuzosin a clinically meaningful option compared to tamsulosin or silodosin.
The medication is widely available as an inexpensive generic and covered by most insurance plans. Key reminders: always take with food, never crush or chew the tablet, and be aware of important contraindications with CYP3A4 inhibitors and other alpha-blockers.
If your pharmacy is out of Alfuzosin XR, don't give up after one call. Use medfinder to locate pharmacies near you that have your medication in stock, saving you the time and frustration of calling around yourself.
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Our medication guides are researched and written to help patients make informed decisions. All content is reviewed for accuracy and updated regularly. Learn more about our standards
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