What Is Yupelri? Uses, Dosage, and What You Need to Know in 2026

Yupelri (revefenacin) is a prescription inhaled medication used to treat chronic obstructive pulmonary disease (COPD) in adults. It is the first and only once-daily long-acting muscarinic antagonist (LAMA) available as a nebulizer solution in the United States. It was approved by the FDA on November 9, 2018, and is manufactured by Viatris Specialty LLC.

What Is Yupelri Used For?

Yupelri is FDA-approved for the maintenance treatment of COPD in adults. COPD is a chronic lung disease that includes two main conditions:

Chronic bronchitis: Long-term inflammation of the airway lining, causing persistent cough and mucus production

Emphysema: Damage to the air sacs (alveoli) in the lungs, reducing the surface area available for oxygen exchange

Yupelri helps keep the airways open and reduces symptoms like wheezing, shortness of breath, chest tightness, and cough. It is a maintenance medication, meaning it is taken every day to prevent symptoms — it is NOT a rescue medication for sudden breathing emergencies.

What Makes Yupelri Different From Other COPD Medications?

Most COPD bronchodilators come as dry powder inhalers (DPIs) or pressurized metered-dose inhalers (MDIs) — handheld devices that require specific breathing technique to deliver the medication properly. Yupelri is different: it is an inhalation solution used with a standard jet nebulizer connected to an air compressor.

With a nebulizer, you simply breathe normally through a mouthpiece while the machine converts the liquid medication into a fine mist. This makes Yupelri especially valuable for:

Elderly patients with reduced hand strength or coordination (arthritis, tremor)

Patients with cognitive limitations who can't reliably perform multistep inhaler techniques

Patients with severe COPD who already use a home nebulizer for other medications

How Does Yupelri Work?

Yupelri is classified as a long-acting muscarinic antagonist (LAMA) — also called an anticholinergic bronchodilator. In COPD, the muscles surrounding the airways are overly tight, making breathing difficult. Yupelri works by blocking muscarinic M3 receptors in the airway smooth muscle, preventing acetylcholine (a chemical messenger) from causing the muscles to tighten. The result is relaxed, more open airways and easier breathing.

Each dose of Yupelri provides approximately 24 hours of bronchodilation, which is why it's taken just once a day.

What Is the Correct Dose of Yupelri?

The recommended dosage of Yupelri is:

One 175 mcg unit-dose vial (3 mL) administered by oral inhalation once daily via a standard jet nebulizer with a mouthpiece.

Each foil pouch contains one pre-measured unit-dose vial. The nebulization process takes approximately 8 minutes using a PARI LC Sprint nebulizer with a PARI Trek S compressor. Yupelri can be used with any standard jet nebulizer — it does not require a proprietary device.

How to Take Yupelri: Step-by-Step

Open the foil pouch immediately before use — don't open it in advance.

Twist open the unit-dose vial and check that the solution is clear and colorless. Do not use if it's cloudy or discolored.

Squeeze all of the solution into the nebulizer cup.

Attach the mouthpiece and connect to your air compressor.

Breathe calmly, deeply, and evenly through the mouthpiece until the medication is fully delivered (approximately 8 minutes).

Discard the empty vial — it is single-use only. Never save or reuse solution.

Important: Do not mix Yupelri with other medications in the nebulizer. Do not inject or swallow the solution.

Who Should Not Take Yupelri?

Anyone with a known allergy to revefenacin or any ingredient in Yupelri

Children (Yupelri is approved only for adults)

Patients with liver disease (hepatic impairment of any degree)

Patients experiencing an acute COPD attack — Yupelri is not a rescue medication

How Is Yupelri Supplied?

Yupelri comes as a sterile, clear, colorless aqueous solution in low-density polyethylene (LDPE) unit-dose vials. Each vial contains 175 mcg of revefenacin in 3 mL of solution. The vials are individually wrapped in foil pouches to protect from light. A 30-day supply consists of 30 unit-dose vials.

For a deeper dive into how Yupelri works at a cellular level, read: How Does Yupelri Work? Mechanism of Action Explained. If you're having trouble filling your prescription, medfinder.com can help you find a pharmacy near you with Yupelri in stock.