How to Save Money on Yupelri in 2026: Coupons, Discounts, and Patient Assistance

Yupelri (revefenacin) has a list price of $1,655.34 per 30-day supply — one of the higher-priced COPD medications on the market. But the good news is that most patients don't pay anywhere near that amount. Between manufacturer savings programs, insurance coverage, and third-party discount services, there are multiple paths to affordable Yupelri. Here's what's available in 2026.

What Does Yupelri Actually Cost?

Here's a breakdown of Yupelri pricing across different scenarios:

List price (WAC): $1,655.34 per 30-day supply (per Viatris)

Average retail price: $1,625–$1,826 per 30-day supply (30 vials of 175 mcg/3 mL)

With GoodRx coupon: Approximately $1,439 per 30-day supply (about 21% off retail)

With commercial insurance + Savings Card: As little as $0 per month (up to 12 fills per year)

Medicare Part B: 80% covered; patient pays ~20% copay (reduced to $0 with Medigap supplemental insurance)

Option 1: The Yupelri Savings Card (For Commercially Insured Patients)

The most powerful savings option for commercially insured patients is the Yupelri Savings Card from Viatris. Here's how it works:

Eligible commercially insured patients may pay as little as $0 per monthly fill

Valid for up to 12 fills per calendar year (one per month)

Enroll at activatethecard.com/yupelri or yupelri.com/copay

For questions, call the LoyaltyScript program at 866-255-9018 (Mon–Fri 8 AM–8 PM EST)

Important restrictions: The savings card is NOT available to Medicare, Medicaid, TRICARE, VA, or other government-funded healthcare program beneficiaries. It is also not valid for uninsured patients (except commercially insured patients without Yupelri-specific coverage). Massachusetts residents may face additional restrictions per state law.

Option 2: Medicare Coverage (Part B)

If you have Medicare, Yupelri is typically covered under Medicare Part B as a nebulized medication administered as durable medical equipment (DME) — not under Part D like most oral prescriptions. Medicare Part B covers 80% of the allowable cost. Your 20% copay responsibility can be a significant amount given Yupelri's price.

If you have Medigap (Medicare supplemental insurance), it may cover your 20% share, potentially reducing your cost to $0. Medicare Advantage plans also cover Yupelri — check your plan's formulary. Medicare Part D may also cover Yupelri in some plans, particularly in nursing facility settings. About 90% of patients with commercial or employer-sponsored insurance pay $0 out of pocket for Yupelri, per Viatris data.

Option 3: Viatris Patient Assistance Program (Uninsured/Underinsured)

For patients who are uninsured or underinsured and cannot afford Yupelri, the Viatris Patient Assistance Program (Group One Medicines) provides the medication at no cost to qualifying patients. Here's how to apply:

Call: 800-796-9526

Email: ViatrisPAP@viatris.com

Fax application to: 877-427-7290

Eligibility period: 12 months (maximum 11 refills per enrollment)

Option 4: GoodRx and Other Discount Programs

If you don't qualify for the savings card or patient assistance program, third-party prescription discount services can reduce your cost somewhat. GoodRx coupons bring the price of Yupelri down to approximately $1,439 per 30-day supply — about 21% below the average retail price of $1,826. Similar discounts are available through Optum Perks, RxSaver, and SingleCare.

While these discounts don't bring the cost to $0, they represent meaningful savings for uninsured patients waiting for patient assistance program approval, or for commercially insured patients in coverage gap situations.

Note: Discount coupons cannot be used with insurance. You must choose one or the other — use insurance if your copay is lower, or use the discount program if you're paying cash.

Option 5: Get a 90-Day Supply via Mail-Order

Many insurance plans offer lower copays for 90-day supplies through mail-order pharmacy compared to monthly retail fills. Check with your plan's pharmacy benefit manager (Express Scripts, CVS Caremark, Optum Rx) to see if a 90-day mail-order supply reduces your per-dose cost. This is especially relevant for Medicare Advantage and commercial plan members.

When Savings Programs Don't Cover the Full Cost

If cost remains a significant barrier after exploring all the options above, talk to your doctor about whether an alternative LAMA medication — such as generic umeclidinium (formerly Incruse Ellipta) — might be clinically appropriate for your situation. See our article on alternatives to Yupelri. And remember: finding a pharmacy that has Yupelri in stock is the first step. Use medfinder.com to locate pharmacies near you that can fill your prescription.