What Is Trivora 28 Day? Uses, Dosage, and What You Need to Know in 2026

Trivora 28 Day is a prescription combination oral contraceptive pill — commonly called "the pill" — used to prevent pregnancy. It's been prescribed in the United States for decades and remains one of the most well-studied hormonal contraceptive options available. Here's everything you need to know about Trivora 28 Day in plain language.

What Is Trivora 28 Day?

Trivora 28 Day is a

triphasic combination oral contraceptive containing two hormones: levonorgestrel (a synthetic progestin) and ethinyl estradiol (a synthetic estrogen). The "triphasic" part means the hormone doses change in three phases across the 21 active tablets in each pack, designed to more closely mimic the body's natural hormonal cycle.

Trivora 28 Day is made by Mayne Pharma and is a generic equivalent of the original Triphasil-28, which was developed decades ago. It is equivalent to other generics including Enpresse-28 (largely discontinued by Teva), Levonest-28, and Myzilra-28.

What Is Trivora 28 Day Used For?

Trivora 28 Day is FDA-approved for one primary use:

prevention of pregnancy. When taken correctly and consistently (one pill at the same time every day), combination oral contraceptives are highly effective — with a typical-use failure rate of about 7% per year and a perfect-use failure rate of less than 1% per year.

In addition to preventing pregnancy, combination oral contraceptives like Trivora 28 Day are commonly associated with several noncontraceptive health benefits:

• More regular, lighter, and less painful menstrual periods
• Reduced risk of iron-deficiency anemia from heavy bleeding
• Decreased incidence of functional ovarian cysts
• Reduced long-term risk of ovarian and endometrial cancer
• Decreased risk of pelvic inflammatory disease

What's in Each Pack of Trivora 28 Day?

Each 28-tablet blister pack contains four types of tablets:

• 6 blue tablets (Phase 1): 0.05 mg levonorgestrel + 0.03 mg ethinyl estradiol
• 5 white tablets (Phase 2): 0.075 mg levonorgestrel + 0.04 mg ethinyl estradiol
• 10 pink tablets (Phase 3): 0.125 mg levonorgestrel + 0.03 mg ethinyl estradiol
• 7 peach tablets (inactive/placebo): No hormones — taken during the withdrawal bleed week to maintain the daily habit

How Do You Take Trivora 28 Day?

Take one tablet daily in the order shown on the pack — starting with the blue tablets, then white, then pink, then peach — at the same time each day. Taking it in the evening with dinner or at bedtime can reduce nausea.

When starting for the first time, begin on the first day of your menstrual period (Day 1 start) for immediate protection. If you start on another day (Sunday start), use backup contraception for the first 7 days.

After finishing the 28-tablet pack, start the next pack the very next day — even if your period hasn't ended or hasn't started yet.

Who Should NOT Take Trivora 28 Day?

Trivora 28 Day is not appropriate for everyone. Do not use it if you:

• Smoke cigarettes and are over 35 years old
• Have a history of blood clots, stroke, or heart attack
• Have uncontrolled high blood pressure
• Have known or suspected breast cancer
• Have active liver disease
• Are pregnant or think you might be pregnant
• Have migraines with aura (focal neurological symptoms)

Always tell your healthcare provider your full medical history and all medications you take before starting Trivora 28 Day.

Where Can I Fill My Trivora 28 Day Prescription?

Trivora 28 Day can be filled at most pharmacies, though local stocking can be inconsistent. Use medfinder to find which pharmacies near you have it in stock before making the trip.

Want a deeper dive into the science? Read: How Does Trivora 28 Day Work? Mechanism of Action Explained.