What Is Symbravo? Uses, Dosage, and What You Need to Know in 2026

Symbravo is a prescription medication approved by the FDA in January 2025 for adults who suffer from migraines. If you've just been prescribed Symbravo — or are researching it as a potential option — this guide covers everything you need to know: what it is, what it treats, how to take it correctly, and important safety information.

What Is Symbravo?

Symbravo is a brand-name oral tablet that combines two medications in one: meloxicam (20 mg) and rizatriptan (10 mg). It's manufactured by Axsome Therapeutics, a company specializing in central nervous system conditions. Before the FDA approved Symbravo under its current name, it was studied under the name AXS-07.

Meloxicam: A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation. It's been approved since 2000 under the brand Mobic for conditions like osteoarthritis. In Symbravo, it's formulated using MoSEIC technology to absorb faster than standard meloxicam.

Rizatriptan: A triptan medication — a type of drug specifically designed to treat migraine attacks. Rizatriptan (brand name Maxalt, now generic) has been used since 1998 and is known for its fast onset among oral triptans.

What Is Symbravo Used For?

Symbravo is FDA-approved for one specific use:

Acute treatment of migraine with or without aura in adults

This means Symbravo is used to stop or reduce a migraine that has already started — it is NOT used to prevent future migraines from occurring. It is also NOT approved for cluster headache treatment.

"Aura" refers to neurological symptoms that some people experience before or during a migraine — such as visual disturbances (flashing lights, blind spots), tingling sensations, or speech difficulties. Symbravo is effective whether or not you experience aura with your migraines.

How Should I Take Symbravo?

Take Symbravo exactly as prescribed by your doctor. Here are the key dosing rules:

Dose: One tablet (meloxicam 20 mg / rizatriptan 10 mg) taken by mouth as needed when a migraine starts

Maximum daily dose: One tablet per day — do not take a second dose for the same attack

With or without food: Symbravo can be taken either way. However, a high-fat, high-calorie meal significantly delays absorption. If you take it with food, meloxicam still reaches effective levels within about 1.5 hours.

Swallow whole: Do not cut, crush, or chew Symbravo tablets

NOT substitutable: Do not substitute with meloxicam and rizatriptan taken separately — the MoSEIC formulation changes how the drugs are absorbed

When Should I Take Symbravo During a Migraine Attack?

Research suggests that taking Symbravo early in a migraine attack produces better outcomes. The INTERCEPT trial showed excellent results when patients treated their migraine while pain was still mild. However, Symbravo also demonstrated significant effectiveness in the MOMENTUM trial when taken during moderate-to-severe attacks — so don't wait until you're debilitated if you've already confirmed it's a migraine.

Take Symbravo at the first sign that a migraine has begun. If you're unsure whether it's a migraine, consult your doctor — Symbravo should only be used when you have a confirmed migraine diagnosis.

Who Should NOT Take Symbravo?

Symbravo is contraindicated (not safe) for patients who:

Have coronary artery disease or significant cardiovascular disease

Have taken another triptan or ergot-type medication in the past 24 hours

Are currently taking or have recently taken (within 14 days) a MAO-A inhibitor

Are allergic to meloxicam, rizatriptan, NSAIDs, or aspirin (history of aspirin-sensitive asthma)

Have moderate-to-severe kidney problems (renal insufficiency) with volume depletion risk

Are within 10–14 days of coronary artery bypass graft (CABG) surgery

Is Symbravo a Controlled Substance?

No. Symbravo is not a DEA-scheduled controlled substance. It does not contain any opioids or other controlled ingredients. This means any licensed prescriber can write a prescription for it, including via telehealth, and there are no federally mandated limits on how it can be dispensed beyond standard prescription rules.

Is There a Generic for Symbravo?

No. As of 2026, there is no generic version of Symbravo. The drug was just approved in January 2025, and patent protection means a generic equivalent won't be available for years. This is one reason the drug's cash price is high (~$1,300–$1,420 for 9 tablets) and why savings programs from Axsome Therapeutics are important for patient access.

For help managing the cost, read our guide on how to save money on Symbravo in 2026.

If you're struggling to find Symbravo in stock at a pharmacy near you, medfinder can help by calling pharmacies on your behalf and texting you the results.