Phexx Is a Non-Hormonal Vaginal Contraceptive Gel Used On-Demand Before Intercourse to Prevent Pregnancy

Phexx (also marketed as Phexxi) is an FDA-approved, non-hormonal vaginal gel that prevents pregnancy by maintaining the natural acidity of the vagina. Unlike birth control pills, patches, or hormonal IUDs, Phexx contains no hormones — it uses a combination of Lactic Acid, Citric Acid, and Potassium Bitartrate to keep vaginal pH in the range that limits sperm movement.

Here's everything you need to know about Phexx in 2026, from how it works to what it costs.

What Is Phexx?

Phexx is a prescription vaginal gel contraceptive. Here are the key facts:

• Brand name: Phexx (also known as Phexxi)
• Generic name: Lactic Acid, Citric Acid, and Potassium Bitartrate vaginal gel
• Drug class: Non-hormonal vaginal contraceptive (acid-buffering spermicidal gel)
• Manufacturer: Evofem Biosciences, Inc.
• FDA-approved: Yes, for prevention of pregnancy
• Controlled substance: No — Phexx is not a controlled substance
• Generic available: No generic version is currently available

What Is Phexx Used For?

Phexx is FDA-approved for one indication:

• Prevention of pregnancy in females of reproductive potential, as an on-demand method of contraception

It is meant to be used each time you have vaginal intercourse. It is not a daily medication — you only use it when you need it.

There has been some off-label interest in Phexx for bacterial vaginosis prevention due to its pH-regulating properties, but this is investigational and not an approved use.

How Is Phexx Taken?

Phexx comes as a 5-gram pre-filled vaginal applicator. Each box contains 12 applicators.

Dosage Instructions

1. Insert one pre-filled applicator of Phexx (5 grams) vaginally immediately before or up to one hour before each act of vaginal intercourse.
2. If more than one act of intercourse occurs within one hour, apply an additional dose.
3. Each applicator is single-use — do not reuse applicators.

Important Timing Notes

• Phexx is not effective when used after intercourse. It must be applied before.
• You can use Phexx during any part of your menstrual cycle.
• You can start using Phexx as soon as it is safe to resume intercourse after childbirth, abortion, or miscarriage.

The active ingredients are Lactic Acid (1.8%), Citric Acid (1%), and Potassium Bitartrate (0.4%). For more on how these ingredients work together, see our article on how Phexx works.

Who Should Not Take Phexx?

Phexx is not appropriate for everyone. You should not use Phexx if you have:

• A history of recurrent urinary tract infections (UTIs) or urinary tract abnormalities — Phexx may increase UTI risk
• A known allergy to Lactic Acid, Citric Acid, Potassium Bitartrate, or any inactive ingredient in the gel

Additionally:

• Do not use Phexx with a vaginal ring — they should not be used together
• Phexx is not effective after intercourse — it is not a form of emergency contraception
• Discontinue if you become pregnant — Phexx is a contraceptive, not for use during pregnancy

For a complete list of side effects and risks, see our Phexx side effects guide.

How Much Does Phexx Cost?

Here's what you can expect to pay for Phexx in 2026:

• Retail cash price: About $795 for a box of 12 applicators
• With insurance: Most plans cover Phexx at no cost under the ACA contraceptive mandate. Some plans may require prior authorization.
• With coupons: SingleCare coupons can reduce the cash price to approximately $374 for 12 applicators
• Medicaid: Coverage varies by state
• Manufacturer programs: Evofem offers savings programs through phexx.com, including copay assistance for commercially insured patients and telehealth with home delivery

For a complete breakdown of savings options, read our guide to saving money on Phexx.

Final Thoughts

Phexx is a unique contraceptive option for people who want hormone-free, on-demand birth control. It's easy to use — just one applicator before intercourse — and it's covered by most insurance plans at no cost.

If Phexx sounds right for you, talk to your doctor or find a prescriber near you. When you're ready to fill your prescription, use Medfinder to check which pharmacies have it in stock.