What Is Pandel? Uses, Dosage, and What You Need to Know in 2026

If you've been prescribed Pandel or have seen it mentioned in connection with your skin condition, you likely want a clear, no-jargon explanation of what it is and what to expect. Here's everything you need to know about Pandel in 2026.

What Is Pandel?

Pandel is a brand-name prescription topical cream containing hydrocortisone probutate at a concentration of 0.1% (1 mg per gram of cream). It is a synthetic corticosteroid — a lab-made version of the natural hormone cortisol — used specifically on the skin to reduce inflammation and itching. Pandel was first approved by the FDA in 1997 and is currently manufactured and distributed by ANI Pharmaceuticals, Inc.

Pandel belongs to the class of medications called topical corticosteroids and is classified as medium potency — stronger than over-the-counter 1% hydrocortisone creams, but not as strong as high-potency products like clobetasol propionate.

What Is Pandel Used For?

Pandel is FDA-approved for the relief of inflammation and itching caused by skin conditions that respond to corticosteroids — known as corticosteroid-responsive dermatoses — in adults 18 years of age and older. Specific conditions for which Pandel is commonly prescribed include:

Atopic dermatitis (eczema)

Contact dermatitis (allergic or irritant)

Seborrheic dermatitis

Plaque psoriasis and scalp psoriasis

Lichen simplex chronicus (localized neurodermatitis)

Discoid lupus erythematosus

Granuloma annulare

Pruritus ani (anal itching) and genital pruritus

What Does Pandel Come In?

Pandel is available as a cream formulation only, in one strength: 0.1% hydrocortisone probutate. It comes in an 80-gram tube (NDC 62559-325-80). The cream base contains propylene glycol, white petrolatum, light mineral oil, stearyl alcohol, and other inactive ingredients that make it cosmetically acceptable for daily use.

There is no ointment, lotion, solution, or gel formulation of Pandel, and there is no generic version of hydrocortisone probutate available in the United States as of 2026.

How to Use Pandel: Dosage and Application Instructions

Your dermatologist or prescribing provider will give you specific instructions, but the standard FDA-approved directions for Pandel are:

Wash and dry your hands before applying.

Clean and dry the affected skin area.

Apply a thin film of Pandel to the affected area once or twice daily (as directed based on severity).

Gently massage until the cream disappears.

Wash your hands after applying (unless treating your hands).

Discontinue once control is achieved — do not continue using it as a preventive measure unless your doctor says to.

If there is no improvement after 2 weeks, contact your doctor — your diagnosis may need to be reassessed.

39,333+ patients found their medications in stock

39K+

Find Pandel In Stock Today →

What NOT to Do With Pandel

Do not apply to the face, groin, or armpits unless your doctor specifically directs it

Do not use in the diaper area — diapers act as occlusive dressings and increase absorption

Do not apply under bandages or wrap the area unless directed by your doctor

Do not get it in your eyes, nose, or mouth

Do not use it on skin that has an active infection

Do not share Pandel with others, even if they have similar symptoms

Is Pandel a Controlled Substance?

No. Pandel is not a DEA-scheduled controlled substance. It is a prescription drug — meaning you need a valid prescription from a licensed provider to obtain it — but it has no abuse potential and is not subject to the prescribing restrictions that apply to opioids or other controlled substances.

Skip the calls, skip the stress.

Find Pandel In Stock Today →

50K+

Medications
Found

99%

Success
Rate

6+

Hours saved
on average

Finding Pandel in Stock Near You

Pandel is a brand-name-only drug with no generic equivalent, which means not all pharmacies stock it routinely. If you're having trouble finding it, medfinder can search pharmacies near you to locate which ones have it available. Enter your medication, dosage, and location and get results texted to you directly.

Want to understand how Pandel works at a deeper level? See our guide on how Pandel works for a plain-English explanation of its mechanism of action.