What Is Myrbetriq? Uses, Dosage, and What You Need to Know in 2026

Myrbetriq is a prescription medication used to treat overactive bladder (OAB) — a condition that causes sudden urges to urinate, frequent urination, and sometimes urinary leakage. Here's everything you need to know about what Myrbetriq is, what it treats, how to take it, and how much it costs.

What Is Myrbetriq?

Myrbetriq is the brand name for mirabegron, an extended-release tablet manufactured by Astellas Pharma US, Inc. It was first approved by the FDA in 2012 and belongs to a drug class called beta-3 adrenergic agonists — a newer, different class from the anticholinergic drugs that dominated OAB treatment for decades.

Unlike anticholinergics (such as oxybutynin, tolterodine, and solifenacin), Myrbetriq works by relaxing the bladder muscle during filling rather than by blocking nerve signals. This targeted mechanism results in fewer systemic side effects — particularly the dry mouth, constipation, and cognitive effects that make older OAB drugs difficult to tolerate.

What Is Myrbetriq FDA-Approved to Treat?

Myrbetriq has two FDA-approved indications:

1. Overactive bladder (OAB) in adults — for symptoms of urge urinary incontinence (leaking urine when you feel the urge to go), urgency, and urinary frequency. Approved as monotherapy or in combination with solifenacin succinate (Vesicare) for patients whose symptoms aren't fully controlled with one drug.
2. Neurogenic detrusor overactivity (NDO) in pediatric patients — for children ages 3 and older who weigh at least 35 kg and have NDO (overactive bladder caused by nerve problems such as spina bifida or spinal cord injury). In children under 35 kg, the granule/oral suspension formulation is used.

Myrbetriq Dosage: How Much Should You Take?

Myrbetriq comes in two strengths: 25 mg and 50 mg extended-release tablets.

• Starting dose: 25 mg taken orally once daily
• After 4-8 weeks: Dose may be increased to 50 mg once daily based on individual efficacy and tolerability
• Maximum dose: 50 mg once daily. Higher doses (100 mg) have been studied but are not approved due to increased blood pressure and heart rhythm risks.
• Dose adjustments: Patients with severe kidney impairment (eGFR 15-29) or moderate liver disease (Child-Pugh B) should not exceed 25 mg daily. Not recommended for eGFR <15 or dialysis.

How to Take Myrbetriq

• Take once daily at the same time each day
• Swallow the tablet whole with water — do NOT crush, chew, or break it (extended-release mechanism)
• Can be taken with or without food (adults)
• If you miss a dose and more than 12 hours have passed, skip it and take the next dose at your regular time

How Long Does It Take for Myrbetriq to Work?

Most patients notice a meaningful improvement in OAB symptoms — fewer urgent bathroom trips, less urinary frequency, reduced leakage — within 4 to 8 weeks of starting Myrbetriq. Clinical trials showed statistically significant reductions in incontinence episodes, urgency episodes, and daily urination frequency compared to placebo by week 12.

What Forms Does Myrbetriq Come In?

• Extended-release tablets: 25 mg and 50 mg — for adults and pediatric patients ≥35 kg
• Granules for oral suspension: 8 mg/mL — for pediatric patients with NDO (weight-based dosing; taken with food). Not substitutable with tablets on a mg-per-mg basis.

How Much Does Myrbetriq Cost?

Without insurance, brand-name Myrbetriq costs approximately $457-$625 for 30 tablets. Generic mirabegron ER — bioequivalent and FDA-approved — is available as low as $117 with GoodRx coupons at some pharmacies. Most insurance plans cover Myrbetriq or its generic, though prior authorization or step therapy may be required.

For savings tips see How to Save Money on Myrbetriq. To understand how it works, see How Does Myrbetriq Work?.