Updated: January 25, 2026

What Is Mifeprex? Uses, Dosage, and What You Need to Know in 2026

Author

Peter Daggett

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Basic Drug Facts
What Is Mifeprex Used For?
How Is Mifeprex Taken? The Standard Dosage
Who Should Not Take Mifeprex?
How to Get Mifeprex in 2026

Mifeprex (mifepristone) is an FDA-approved oral medication used with misoprostol to end an early pregnancy. Here's everything you need to know about it in 2026.

Mifeprex is the brand name for mifepristone, an FDA-approved oral tablet that has been used safely and effectively in the United States since 2000. It is best known as part of the two-drug medication abortion regimen, though it is also used (under a different brand name, Korlym) to treat a hormonal condition called Cushing's syndrome. This guide focuses on Mifeprex and its use for medical termination of pregnancy.

Basic Drug Facts

Generic name: Mifepristone

Brand name: Mifeprex (by Danco Laboratories)

Generics available: Yes — GenBioPro (approved 2019), Evita Solutions (approved October 2025)

Drug class: Progesterone receptor modulator (antiprogestational steroid)

Dosage form: Oral tablet, 200 mg

FDA approval date: September 28, 2000

Controlled substance: Not a federally scheduled controlled substance

Special restrictions: FDA Mifepristone REMS Program (requires certified prescribers and pharmacies)

What Is Mifeprex Used For?

Mifeprex (mifepristone 200 mg) is FDA-approved for one indication: the medical termination of intrauterine pregnancy through 70 days (10 weeks) of gestation, in combination with misoprostol. The gestational age is counted from the first day of the patient's last menstrual period.

Medication abortion accounts for nearly two out of every three abortions in the United States. When used correctly, the mifepristone-plus-misoprostol combination is approximately 97% effective in the first 63 days (9 weeks) of pregnancy. About 2 to 7 out of 100 people will need a surgical procedure because the pregnancy did not completely pass.

Other uses of mifepristone (not covered under the Mifeprex brand for this purpose):

Korlym (mifepristone 300 mg/day) for Cushing's syndrome with type 2 diabetes

Off-label: medical management of early pregnancy loss (miscarriage), cervical preparation before procedures

How Is Mifeprex Taken? The Standard Dosage

The FDA-approved medication abortion regimen is a two-step process:

Day 1: Take one 200 mg Mifeprex tablet orally (swallowed whole with water).

Day 2–3 (24–48 hours later): Take misoprostol 800 mcg buccally: place two 200 mcg tablets in each cheek pouch (between cheek and gum), hold for 30 minutes, then swallow any remaining tablets with water.

Day 14 (7–14 days after Mifeprex): Follow-up with your provider to confirm complete termination.

Who Should Not Take Mifeprex?

Mifeprex is contraindicated in people who have:

A confirmed or suspected ectopic pregnancy (Mifeprex will not terminate an ectopic pregnancy and the ectopic can rupture)

An IUD in place (it must be removed before starting treatment)

Chronic adrenal failure

Bleeding disorders or current anticoagulant therapy

Inherited porphyrias

Allergy to mifepristone, misoprostol, or other prostaglandins

Pregnancy greater than 70 days of gestation

How to Get Mifeprex in 2026

Mifeprex requires a prescription from a REMS-certified prescriber and must be filled at a REMS-certified pharmacy. In states where abortion is legal, it can be obtained in person or via telehealth and mail. medfinder can help you find which pharmacies near you are certified to fill your prescription. See our complete guide: How to find Mifeprex in stock near you.

Frequently Asked Questions

Mifeprex (mifepristone 200 mg) is FDA-approved for the medical termination of intrauterine pregnancy through 70 days (10 weeks) of gestation when used in combination with misoprostol. It is not approved as emergency contraception or for use after 70 days of pregnancy. A different brand of mifepristone (Korlym) is approved to treat Cushing's syndrome.

When used with misoprostol, Mifeprex is approximately 97% effective at ending an early pregnancy (through 63 days or 9 weeks gestation). About 2 to 7 out of 100 people will need a surgical procedure because the pregnancy did not completely pass or bleeding did not stop. Follow-up with your provider 7–14 days after treatment is required to confirm success.

No. Mifeprex (mifepristone) and Plan B (levonorgestrel) are completely different medications. Plan B is an emergency contraceptive that prevents pregnancy when taken within 72 hours of unprotected sex. Mifeprex is used to end an existing pregnancy through 10 weeks of gestation. They work through different mechanisms and are used at different points in pregnancy.

Mifeprex (mifepristone) is not a federally scheduled controlled substance under the DEA's Controlled Substances Act. However, Louisiana has classified mifepristone as a controlled substance under state law. In all other states, it is not subject to controlled substance prescribing requirements, though it is still restricted under the FDA's Mifepristone REMS Program.

Mifepristone has a half-life of approximately 18 hours with a range of 12 to 72 hours depending on the individual. Most of the drug is eliminated within 5 to 7 days. However, the medication completes its action on the pregnancy within the first 24 to 48 hours. After taking misoprostol (Day 2–3), the pregnancy termination process typically begins within 1 to 4 hours.

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