What Is MetroCream? Uses, Dosage, and What You Need to Know in 2026

MetroCream is a prescription topical cream used to treat rosacea, a chronic skin condition that causes redness, bumps, and visible blood vessels on the face. If your dermatologist or doctor has prescribed MetroCream, here's everything you need to know about what it is, how it works, and how to use it effectively.

What Is MetroCream?

MetroCream is the brand name for metronidazole 0.75% topical cream. It contains metronidazole as its active ingredient — a nitroimidazole compound with antibiotic and anti-inflammatory properties. When applied to the skin, it helps reduce the redness, bumps, and pustules caused by rosacea.

The FDA approved MetroCream for rosacea in September 1997. It is available only by prescription in the United States. Generic versions of MetroCream (metronidazole 0.75% topical cream) are also FDA-approved and widely available.

What Is MetroCream Used For?

MetroCream is FDA-approved for the treatment of inflammatory papules and pustules of rosacea — specifically the bumps, pimples, and redness associated with this chronic facial skin condition. Rosacea primarily affects the nose, cheeks, chin, and forehead, causing:

Persistent facial redness (erythema)

Inflammatory papules (red bumps) and pustules (pimple-like lesions)

Visible blood vessels (telangiectasias)

Burning or stinging sensations on facial skin

MetroCream is primarily effective for the inflammatory component (bumps and pustules). It does not directly address visible blood vessels or severe facial redness — additional treatments may be needed for those symptoms.

How to Use MetroCream: Dosage and Application

MetroCream comes in a 45-gram tube. Here is how to use it correctly:

Wash your hands before and after applying.

Cleanse your face gently with a mild cleanser and pat dry.

Wait 15 minutes after washing before applying MetroCream to the affected areas.

Apply a thin layer to affected facial areas once or twice daily, as directed by your doctor. Avoid the eyes.

Wait 5 minutes before applying cosmetics, moisturizer, or sunscreen.

Do not use MetroCream around the eyes unless specifically directed by your doctor. If you experience significant irritation, your doctor may recommend reducing application to once daily.

When Will MetroCream Start Working?

Rosacea treatments take time. Most patients using MetroCream start to see improvement in their bumps and redness after 3–4 weeks of consistent daily use. Significant improvement typically occurs by 8–12 weeks. The key is consistency — using it daily as prescribed.

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Is MetroCream the Same as MetroGel?

MetroCream and MetroGel both contain metronidazole and are used to treat rosacea. The key differences are in formulation. MetroCream is an emollient cream base (0.75%), while MetroGel is available as a 0.75% or 1% gel. The cream formulation may be preferred by patients with dry or sensitive skin, while the gel may suit oilier skin types. Both are available as generics.

Is MetroCream a Controlled Substance?

No. MetroCream is not a controlled substance. It is a prescription medication but has no DEA scheduling and no special refill restrictions beyond what your prescriber writes.

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How Much Does MetroCream Cost?

Brand MetroCream can cost $618–$801 for a 45g tube without insurance. The generic equivalent is far more affordable: $42–$93 retail, or as low as $24–$43 with a GoodRx discount card. Most insurance plans cover the generic at Tier 1 or 2, with copays of $0–$30.

Filling Your MetroCream Prescription

Brand MetroCream may not be at every pharmacy. If you're having trouble finding it, medfinder can contact pharmacies near you to check which ones can fill your prescription, then text you the results. For generic metronidazole 0.75% cream, availability is typically not an issue at major chain pharmacies.

Learn more about what to expect: MetroCream side effects: what to expect and when to call your doctor.