What Is Mavyret? Uses, Dosage, and What You Need to Know in 2026

Mavyret is a prescription medication used to treat hepatitis C virus (HCV) infection. It's made by AbbVie and contains two active ingredients: glecaprevir and pibrentasvir. Together, these two drugs work in combination to stop the hepatitis C virus from replicating in your body—and in most cases, they eliminate the virus entirely within 8 weeks.

What Is Mavyret Used For?

Mavyret is FDA-approved for the treatment of acute and chronic hepatitis C virus (HCV) infection in adults and children 3 years of age and older. It works across all six major HCV genotypes (1, 2, 3, 4, 5, and 6), making it a "pangenotypic" treatment—meaning it works regardless of which type of hepatitis C you have.

Specifically, Mavyret is approved for:

Adults and children 3+ with acute HCV (new infection within the past 6 months) — approved June 2025; first and only DAA approved for acute HCV

Adults and children 3+ with chronic HCV genotypes 1–6, without cirrhosis or with compensated cirrhosis (Child-Pugh A)

Adults and children 3+ with HCV genotype 1 who were previously treated with a regimen containing an NS5A inhibitor OR an NS3/4A protease inhibitor (but not both)

How Effective Is Mavyret?

Mavyret is highly effective. In treatment-naive patients (those who have not previously been treated for HCV), cure rates are 96–98% when treatment is completed as prescribed. "Cure" in this context means achieving a sustained virologic response at 12 weeks after completing treatment (SVR12)—the HCV RNA is undetectable in your blood 12 weeks after your last dose.

Once you achieve SVR12, you are considered cured of hepatitis C. The virus is eliminated from your body. You cannot transmit HCV to others after achieving cure.

How Do You Take Mavyret?

Mavyret comes in two forms:

Tablets: 100 mg glecaprevir / 40 mg pibrentasvir per tablet. Adults and older children take 3 tablets at the same time, once daily with food.

Oral pellets: 50 mg glecaprevir / 20 mg pibrentasvir per packet. Used for younger children or those who cannot swallow tablets. Sprinkled onto soft food with low water content (like peanut butter or Nutella). Do NOT chew pellets.

The total adult daily dose is 300 mg glecaprevir + 120 mg pibrentasvir (3 tablets or 6 packets).

How Long Do You Take Mavyret?

Treatment duration depends on your HCV genotype, liver health, and prior treatment history:

8 weeks: Most treatment-naive patients with or without compensated cirrhosis; acute HCV patients

12 weeks: Genotype 1 patients previously treated with an NS5A inhibitor (but not a protease inhibitor)

16 weeks: Genotype 1 patients with NS3/4A PI treatment failure (with sofosbuvir and ribavirin)

Important Things to Know Before and During Treatment

Always take with food — absorption is significantly reduced on an empty stomach

Don't skip doses — if you miss a dose and it's less than 18 hours since your usual dose time, take it immediately. If more than 18 hours, skip and resume your normal schedule.

You'll need HBV testing before starting — Mavyret has a boxed warning for hepatitis B reactivation

Avoid certain drugs — including atazanavir, rifampin, carbamazepine, and St. John's Wort (these can make Mavyret fail)

Mavyret is NOT a controlled substance and can be prescribed by any licensed provider

Who Should NOT Take Mavyret?

Patients with moderate or severe liver impairment (Child-Pugh B or C)

Patients with any history of liver decompensation

Patients taking atazanavir or rifampin (absolute drug interactions)

Children under 3 years of age

How to Fill Your Mavyret Prescription

Mavyret is a specialty medication that requires prior authorization from your insurance and is typically dispensed through specialty pharmacies. medfinder can help you find which pharmacies near you have it in stock and can fill your prescription. For cost-saving options, see our complete guide: how to save money on Mavyret in 2026.