What Is Gimoti? Uses, Dosage, and What You Need to Know in 2026

Gimoti is a prescription nasal spray used to treat a condition called diabetic gastroparesis — a complication of diabetes where the stomach empties too slowly. It contains the active ingredient metoclopramide and is the only FDA-approved nasal spray for this indication. Here's everything you need to know about Gimoti in 2026.

What Is Gimoti Used For?

Gimoti is FDA-approved for:

Relief of symptoms in adults with acute and recurrent diabetic gastroparesis.

Diabetic gastroparesis occurs when the autonomic nerve damage caused by diabetes slows or paralyzes stomach muscles, leading to delayed gastric emptying. Symptoms include:

Nausea and vomiting

Feeling full quickly (early satiety)

Bloating and abdominal fullness

Upper abdominal pain or discomfort

Heartburn and regurgitation

What Makes Gimoti Different From Other Metoclopramide Products?

Gimoti contains the same active ingredient as Reglan (oral metoclopramide tablets) — but it's delivered through the nose. This nasal route has a key advantage in gastroparesis: it bypasses the stomach entirely. Because gastroparesis slows stomach emptying, an oral pill may also be absorbed slowly and unpredictably. Gimoti's nasal delivery gets metoclopramide into the bloodstream without relying on gastric absorption.

Pharmacokinetic studies confirmed that Gimoti 15 mg nasal spray is bioequivalent to oral metoclopramide 10 mg — meaning it delivers a similar amount of drug to the bloodstream.

Who Manufactures Gimoti?

Gimoti is manufactured by Patheon (a Thermo Fisher division) for Evoke Pharma, Inc., a specialty pharmaceutical company based in Solana Beach, California. Evoke Pharma holds the trademark for Gimoti and manages the patient support program through ASPN Pharmacies. The medication received FDA approval in 2020.

Gimoti Dosage: How Much to Take and When

Standard dose: 1 spray (15 mg) in 1 nostril, 30 minutes before each meal and at bedtime (up to 4 times daily).

Duration: 2 to 8 weeks per treatment course, depending on symptom response.

Maximum total duration: 12 weeks (all metoclopramide products combined).

Bottle contents: 9.8 mL — sufficient for 4 weeks of 4x/day dosing. Discard 4 weeks after opening.

How to Use Gimoti Nasal Spray Correctly

Prime the pump before first use (or if unused for 2+ weeks): press and release 10 sprays into the air.

Tilt your head slightly forward — NOT back.

Place the spray nozzle under 1 nostril, aimed away from the septum and toward the back of the nose.

Close the other nostril. Press the pump firmly and breathe in gently through the open nostril.

Remove the nozzle and breathe out slowly through the mouth.

Wipe the nozzle with a clean tissue and replace the cap.

Who Should NOT Use Gimoti?

History of tardive dyskinesia or dystonic reaction to metoclopramide.

Parkinson's disease.

GI bleeding, blockage, or perforation.

Pheochromocytoma or other catecholamine-releasing tumors.

Epilepsy.

Moderate-severe kidney or liver impairment.

Children under 18.

How Much Does Gimoti Cost?

Gimoti's retail cash price is approximately $2,499–$2,825 per bottle (4-week supply). However, most patients pay far less. With Evoke Pharma's savings program through ASPN Pharmacies, eligible commercial insurance patients pay $0, and patients without coverage pay just $20. Medicare and Medicaid patients should verify coverage through their specific plan.

Getting Gimoti Filled

Gimoti is only dispensed through ASPN Pharmacies — your doctor must send the prescription there, not to a retail pharmacy. For other medications in your treatment regimen, medfinder can help you quickly locate which pharmacies near you have your prescriptions in stock.

Want to understand how Gimoti works in your body? Read our explainer: How Does Gimoti Work? Mechanism of Action Explained in Plain English.