What Is Fyremadel? Uses, Dosage, and What You Need to Know in 2026

If you've just been prescribed Fyremadel as part of your IVF treatment, you likely have a lot of questions. What is it, exactly? What does it do? How do you inject it? How much does it cost? This guide answers all of those questions in plain language.

What Is Fyremadel?

Fyremadel is the brand name for ganirelix acetate, an injectable medication manufactured and distributed by Ferring Pharmaceuticals. It belongs to a class of drugs called GnRH antagonists — gonadotropin-releasing hormone antagonists.

Ganirelix acetate was originally approved by the FDA in 1999 under the brand name Antagon. Other brand names include Orgalutran (used outside the US). A generic version is manufactured by Amphastar Pharmaceuticals. Fyremadel is Ferring Pharmaceuticals' branded formulation of the same active ingredient.

What Is Fyremadel Used For?

Fyremadel has one FDA-approved use: inhibition of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation (COH) as part of assisted reproductive technology (ART), primarily in vitro fertilization (IVF).

In simpler terms: when you're going through IVF, your doctor gives you FSH injections to stimulate your ovaries to produce multiple eggs. Fyremadel prevents your body from releasing those eggs too early — before your doctor has a chance to retrieve them. Without Fyremadel (or a similar medication), a premature LH surge could cause you to ovulate spontaneously and ruin the cycle.

Some off-label uses include management of endometriosis and, rarely, precocious puberty — but these are uncommon and not the primary indication.

How Is Fyremadel Supplied?

Fyremadel comes as a prefilled, single-use, sterile glass syringe containing 250 mcg of ganirelix acetate in 0.5 mL of solution. It is intended for subcutaneous (under-the-skin) injection only — not intramuscular. The needle is a 27-gauge, half-inch needle attached to the syringe. Note: The needle shield contains dry natural rubber/latex, which is important to know if you have a latex allergy.

How Is Fyremadel Dosed?

The standard dose is one 250 mcg prefilled syringe, injected subcutaneously once per day. Here's the general timeline:

1. FSH therapy begins on Day 2 or 3 of your menstrual cycle
2. Fyremadel is added on approximately Day 6-8 (or when your lead follicle reaches a certain size per ultrasound)
3. Fyremadel continues daily until at least 3 follicles reach 17 mm or larger
4. Your hCG trigger shot is given, and both FSH and Fyremadel are stopped
5. Egg retrieval follows approximately 36 hours after the hCG trigger

Most patients use Fyremadel for an average of about 5 days (range: 2-14 days), meaning a typical cycle requires 4 to 6 prefilled syringes.

How to Inject Fyremadel

Fyremadel is designed for self-injection at home after instruction from your healthcare provider. Key steps:

• Remove the syringe from the refrigerator 30 minutes before injection to let it reach room temperature
• Wash your hands with soap and water before handling the syringe
• Inject under the skin in the lower abdomen (at least 2 inches from your belly button) or upper thigh
• Rotate injection sites each day to prevent skin irritation
• Store at room temperature (68-77°F); protect from light

Is Fyremadel a Controlled Substance?

No. Fyremadel is not a controlled substance and is not scheduled by the DEA. It has no known abuse potential. However, it is a prescription-only medication that requires a doctor's order.

How Much Does Fyremadel Cost?

At retail price without insurance, a single Fyremadel prefilled syringe costs between $150 and $250. For a typical IVF cycle requiring 4-6 syringes, that's $600 to $1,500. With a GoodRx coupon, generic ganirelix acetate (the same active ingredient) can cost as low as $33-$44 per syringe. Many insurance plans don't cover fertility medications, but 21 states have mandates that may require some coverage.

Where to Find Fyremadel

Fyremadel is not widely stocked at retail pharmacies — it's a specialty medication primarily available through fertility-focused specialty pharmacies. medfinder can help you quickly find which pharmacies near you have Fyremadel in stock. For more on what to watch for once you start treatment, see our guide on Fyremadel side effects.