What Is Depo-SubQ Provera 104? Uses, Dosage, and What You Need to Know in 2026

If you or your provider have discussed using Depo-SubQ Provera 104 for birth control or endometriosis pain, you likely have a lot of questions. What is it exactly? How is it different from regular Depo-Provera? What do you need to know before your first injection? This complete guide covers everything you need to know in 2026.

What Is Depo-SubQ Provera 104?

Depo-SubQ Provera 104 is the brand name for medroxyprogesterone acetate (MPA) 104 mg/0.65 mL injectable suspension, manufactured by Pfizer. It is a progestin-only hormonal contraceptive that is injected subcutaneously (just under the skin) into the thigh or abdomen every 12–14 weeks (approximately every 3 months).

Medroxyprogesterone acetate (MPA) is a synthetic form of the hormone progesterone. Progesterone plays a key role in the female reproductive cycle, and synthetic progestins like MPA can be used to mimic or manipulate those hormonal effects for medical purposes.

What Is Depo-SubQ Provera 104 Used For?

Depo-SubQ Provera 104 is FDA-approved for two indications:

Contraception (birth control): Prevents pregnancy by suppressing ovulation, thickening cervical mucus, and altering the uterine lining. In clinical studies, no women became pregnant during a full year of use when the injection was given on schedule.

Endometriosis-associated pain management: Reduces pelvic pain caused by endometriosis by suppressing estradiol levels, which slows endometriosis tissue growth and reduces associated inflammation. This is one of the few injectable medications with FDA approval for both contraception and endometriosis pain.

How Is Depo-SubQ Provera 104 Different From Depo-Provera CI?

Patients often confuse Depo-SubQ Provera 104 with Depo-Provera CI (150 mg intramuscular). Both contain medroxyprogesterone acetate, but they differ in several important ways:

Dose: Depo-SubQ Provera 104 uses 104 mg; Depo-Provera CI uses 150 mg.

Route: Depo-SubQ Provera 104 is subcutaneous (under the skin); Depo-Provera CI is intramuscular (into the muscle).

Generic: No FDA-approved generic for Depo-SubQ Provera 104; generic medroxyprogesterone 150mg IM is available for Depo-Provera CI.

Administration: Both require administration by a healthcare professional; both are given every 12–14 weeks.

How Is Depo-SubQ Provera 104 Dosed and Administered?

Dose: 104 mg (0.65 mL) subcutaneously every 12–14 weeks.

Injection sites: Anterior thigh or abdomen, rotating sites with each injection.

Who administers it: A licensed healthcare professional. The syringe must be shaken vigorously before use to create a uniform suspension.

First injection timing: For sexually active women with regular menses, the first injection must be given within the first 5 days of a normal menstrual period. Women who are breastfeeding should wait until at least 6 weeks postpartum.

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Who Should NOT Use Depo-SubQ Provera 104?

Depo-SubQ Provera 104 is contraindicated in people who have:

Active thrombophlebitis or a history of blood clots or stroke

Known, suspected, or past breast cancer

Significant liver disease

Undiagnosed vaginal bleeding

Current pregnancy

Current meningioma or history of meningioma (added December 2025)

Important 2025 Safety Update: Meningioma Warning

In December 2025, the FDA added a warning to the Depo-SubQ Provera 104 label regarding a possible increased risk of meningioma (a typically benign brain tumor) with prolonged use. The drug has NOT been recalled and remains available. Discuss the updated risk-benefit profile with your provider, especially if you've been on this medication for more than 1 year.

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Finding Depo-SubQ Provera 104 at Your Pharmacy

Because Depo-SubQ Provera 104 is a brand-only quarterly injectable, many pharmacies don't stock it routinely. If you're having trouble finding it, medfinder can locate which pharmacies near you currently have it in stock by contacting them on your behalf.

For a complete breakdown of what to expect once you start, read our full side effects guide: Depo-SubQ Provera 104 Side Effects: What to Expect and When to Call Your Doctor.