What Is Cloderm? Uses, Dosage, and What You Need to Know in 2026

Cloderm is a prescription topical cream that many dermatologists recommend for inflammatory skin conditions — but for patients who haven't used it before, there's a lot to understand. This guide covers what Cloderm is, what it treats, how to use it correctly, and the key safety facts you need to know in 2026.

What Is Cloderm?

Cloderm is the brand name for clocortolone pivalate 0.1% cream — a mid-potency (Class 4) topical corticosteroid first approved by the FDA on August 22, 1977. It belongs to the corticosteroid family of drugs, which work by reducing inflammation in the skin. Currently distributed by EPI Health, LLC, Cloderm is formulated as a water-washable emollient cream that doesn't contain lanolin, propylene glycol, or added fragrance — features that make it particularly suitable for patients with sensitive skin.

Generic versions — clocortolone pivalate 0.1% cream — are available from manufacturers Dr. Reddy's and Prasco.

What Conditions Does Cloderm Treat?

Cloderm is FDA-approved for corticosteroid-responsive dermatoses — a broad category of skin conditions where inflammation is the key driver. Conditions commonly treated with Cloderm include:

• Atopic dermatitis (eczema): Clinical trials showed statistically significant improvement at Day 4 compared to placebo.
• Psoriasis vulgaris: Phase 3 trials showed superiority to placebo from Day 7 through Day 28.
• Contact dermatitis: Allergic and irritant contact dermatitis respond well to mid-potency topical steroids.
• Seborrheic dermatitis: A common condition causing scaly patches, redness, and itching on the scalp or face.
• Other eczematous dermatoses: Including nummular eczema, dyshidrotic eczema, and similar inflammatory rashes.

How Is Cloderm Dosed?

The standard dosing for Cloderm is:

• Apply sparingly to the affected area three times daily
• Rub in gently until absorbed
• Wash hands after application (unless treating the hands)
• Do not cover or wrap the treated area unless directed by your doctor (occlusive dressings can increase absorption and risk of side effects)

The drug is for external use only. Do not use near the eyes, in the mouth, or vaginally. For the face or sensitive areas (genitals, underarms), use only if specifically directed by your doctor.

What Forms and Sizes Does Cloderm Come In?

Cloderm is available exclusively as a 0.1% cream in three sizes:

• 45 gram tube
• 90 gram tube
• 75 gram pump bottle (convenient for larger treatment areas)

It is not available as an ointment, gel, solution, or lotion — only as a cream. Store between 59°F–86°F (15°C–30°C); avoid freezing.

Is Cloderm a Controlled Substance?

No. Cloderm is not a controlled substance and has no DEA schedule. It requires a prescription, but it can be prescribed by any licensed healthcare provider, refilled as your prescriber directs, and filled at any pharmacy without special handling requirements.

Who Should Not Use Cloderm?

Cloderm is contraindicated in patients who are hypersensitive to clocortolone pivalate or any inactive ingredients in the formulation. Use with caution in:

• Pregnant women (Category C; use only if benefits outweigh risks, in small amounts for short periods)
• Breastfeeding women (avoid applying to the breast; use smallest effective amount)
• Patients with diabetes (topical steroids can increase blood glucose)
• Children (use the smallest effective amount; avoid occlusive dressings)

For a complete overview of side effects and precautions, see our guide to Cloderm side effects.