Alternatives to Cloderm If You Can't Fill Your Prescription

Cloderm (clocortolone pivalate 0.1% cream) is a mid-potency topical corticosteroid that works well for eczema, psoriasis, contact dermatitis, and other inflammatory skin conditions. But when your pharmacy doesn't have it in stock, or your insurance won't cover it, you need a backup plan. This guide covers the most common and medically appropriate alternatives to Cloderm — and what to discuss with your doctor or dermatologist.

Why Alternatives Matter: Understanding Cloderm's Potency Class

Topical corticosteroids are ranked in 7 potency classes, from Class 1 (super-potent, like clobetasol) down to Class 7 (least potent, like low-dose hydrocortisone). Cloderm is a Class 4 (medium potency) topical steroid. When switching, your dermatologist will generally recommend staying within the same potency class or choosing the closest alternative that's actually available and covered by your insurance.

Top Alternatives to Cloderm (Clocortolone Pivalate)

1. Triamcinolone Acetonide (Kenalog, generic)

Triamcinolone acetonide 0.1% cream is one of the most widely prescribed topical steroids in the United States and is the most commonly available mid-potency option. It's a Class 4–5 corticosteroid depending on the formulation (cream vs. ointment vs. lotion). Generics are inexpensive — often $5–$20 with insurance or discount cards — and stocked at virtually every pharmacy. It's a first-line alternative when Cloderm is unavailable.

• Best for: Eczema, dermatitis, psoriasis on body (not face/genitals)
• Note: Widely available, inexpensive, multiple formulations

2. Mometasone Furoate (Elocon, generic)

Mometasone furoate 0.1% cream is a Class 4–5 topical corticosteroid with the advantage of once-daily dosing, compared to Cloderm's three-times-daily regimen. Generic mometasone is widely available and relatively affordable. It's available in cream, ointment, and lotion forms, making it versatile for different skin types and body areas.

• Best for: Eczema, psoriasis, dermatitis; patients who prefer once-daily dosing
• Note: Preferred by many insurers as a step therapy alternative to Cloderm

3. Betamethasone Valerate (Valisone, generic)

Betamethasone valerate 0.1% cream or ointment is a Class 4–5 mid-potency corticosteroid that's been in use for decades. It's available as a generic and is well-stocked at most pharmacies. The cream formulation is appropriate for most body areas but should be used cautiously on the face and skin folds.

• Best for: Moderate eczema and psoriasis on the body
• Note: Less preferred than triamcinolone or mometasone due to slightly higher potency variation

4. Fluocinolone Acetonide (Synalar, generic)

Fluocinolone acetonide 0.025% cream or ointment is another Class 4 mid-potency option that closely matches Cloderm's potency level. Generic versions are available and reasonably priced. Fluocinolone is commonly used for eczema, psoriasis, and seborrheic dermatitis.

• Best for: Patients who need a Class 4 equivalent to Cloderm
• Note: Available in oil formulations for scalp use

Why Cloderm Has Unique Advantages Not All Alternatives Share

Cloderm is specifically formulated without lanolin, propylene glycol, or added fragrance — making it a Category C corticosteroid with an unusually low risk of contact sensitization. If you have sensitive skin or a history of reactions to other topical steroids, your dermatologist may have specifically chosen Cloderm for this reason. Not all alternatives share these same low-allergenicity properties.

When asking your doctor about alternatives, mention any past reactions to other topical steroids so they can factor that into their recommendation.

Nonsteroidal Alternatives for Eczema (When Steroids Are Problematic)

If steroid-related side effects or long-term use restrictions are a concern, your doctor may consider nonsteroidal topical options:

• Tacrolimus (Protopic): A topical calcineurin inhibitor appropriate for eczema on sensitive areas like the face and eyelids.
• Pimecrolimus (Elidel): Mild nonsteroidal option for mild-to-moderate eczema.
• Crisaborole (Eucrisa): A PDE4 inhibitor for mild-to-moderate atopic dermatitis; available for children as young as 3 months.

Talk to Your Doctor Before Switching

Never switch topical steroid medications without consulting your prescriber. Potency class, formulation, body location, and your personal skin history all matter. If you'd prefer to stick with Cloderm, read our guide on how to find Cloderm in stock near you before giving up on your original prescription.