What Is Clinpro 5000? Uses, Dosage, and What You Need to Know in 2026

Clinpro 5000 is a prescription-strength toothpaste manufactured by 3M ESPE (now Solventum) that contains 1.1% sodium fluoride — five times the fluoride concentration found in standard OTC toothpastes. It's prescribed by dentists to patients at moderate to high risk for dental cavities (caries) as part of a professional preventive care program.

What Is Clinpro 5000 Used For?

Per the FDA-approved prescribing information, Clinpro 5000 is indicated for use as part of a professional program for the prevention and control of dental caries. Dentists typically prescribe it to patients who:

Have a history of frequent cavities or active dental decay

Have dry mouth (xerostomia) — often from medications, autoimmune disease, or radiation therapy

Have exposed root surfaces or recession, which are more susceptible to decay

Wear orthodontic appliances, which can trap plaque near enamel

Have white spot lesions — early signs of enamel demineralization

Have many dental restorations (fillings, crowns) or a history of recurrent decay

What Makes Clinpro 5000 Different From Regular Toothpaste?

There are two key differences:

5x more fluoride. Regular OTC toothpastes contain 1,000–1,450 ppm fluoride. Clinpro 5000 contains 5,000 ppm (1.1% sodium fluoride). This higher concentration penetrates deeper into demineralized enamel and provides stronger protection against acid attacks from cariogenic bacteria.

Functionalized tri-calcium phosphate (fTCP). This exclusive ingredient delivers calcium and phosphate simultaneously with fluoride to the tooth surface — working together to rebuild enamel more effectively than fluoride alone.

Clinpro 5000 Dosage: How Much to Use and How Often

The standard dosage is:

Amount: A thin ribbon or pea-sized amount (~0.5 cm) applied to a soft-bristled toothbrush

Frequency: Once daily, in place of regular toothpaste (not in addition to it)

Duration: Brush for at least 2 minutes

After brushing: Adults: spit out, then do not eat, drink, or rinse mouth for at least 30 minutes (best used at bedtime)

Children (6–16): Rinse mouth thoroughly with water immediately after brushing

Children under 6: Do not use unless specifically recommended by a dentist

Available Formulations and Flavors

Clinpro 5000 comes in one concentration — 1.1% sodium fluoride (5000 ppm) — and is available in three flavors:

Vanilla Mint (NDC 48878-3120-4)

Spearmint (NDC 48878-3130-4)

Bubble Gum (NDC 48878-3140-4) — often preferred by younger patients

Each tube is 4 oz (113g) — a 6-month supply when used as directed.

Is Clinpro 5000 a Controlled Substance?

No. Clinpro 5000 is not a controlled substance and is not scheduled by the DEA. While it does require a prescription, there are no special dispensing restrictions, no quantity limits enforced by the DEA, and no requirement for a written (non-faxed) prescription. Most dentists can call it in, fax it, or e-prescribe it.

Who Manufactures Clinpro 5000?

Clinpro 5000 is manufactured by Solventum US OpCo LLC, formerly 3M ESPE Dental Products (3M spun off its healthcare division under the Solventum brand in 2024). It is made at 3M's St. Paul, Minnesota facility.

Finding and Affording Clinpro 5000

Clinpro 5000 is not always easy to find at retail pharmacies. medfinder can help you locate it at pharmacies near you. For cost information, GoodRx and SingleCare offer coupons that reduce the price to as low as $16–$18 per tube — see our full guide on how to save money on Clinpro 5000.