Blujepa Is a First-in-Class Antibiotic for UTIs and Gonorrhea

Blujepa (Gepotidacin) is a prescription antibiotic that treats uncomplicated urinary tract infections and uncomplicated urogenital gonorrhea. It belongs to a new class of antibiotics called triazaacenaphthylene bacterial type II topoisomerase inhibitors — the first drug of its kind approved by the FDA.

If you've been prescribed Blujepa or are researching it, this guide covers everything you need to know: what it is, what it treats, how to take it, who shouldn't use it, and how much it costs.

What Is Blujepa?

Here are the basics:

• Brand name: Blujepa
• Generic name: Gepotidacin (Gepotidacin mesylate)
• Drug class: Triazaacenaphthylene bacterial type II topoisomerase inhibitor
• Manufacturer: GSK (GlaxoSmithKline)
• FDA approval: March 2025 for uncomplicated UTIs; December 2025 for uncomplicated urogenital gonorrhea
• Controlled substance: No — Blujepa is not a controlled substance. It is prescription-only (Rx).
• Generic available: No. As of 2026, there is no generic version of Blujepa.

Blujepa works differently from other antibiotics. It targets bacterial DNA gyrase and topoisomerase IV through a unique binding mechanism that's distinct from fluoroquinolones. You can learn more in our article on how Blujepa works.

What Is Blujepa Used For?

Blujepa is FDA-approved for two conditions:

1. Uncomplicated Urinary Tract Infections (uUTIs)

Blujepa is approved for treating uUTIs in female patients aged 12 and older who weigh at least 40 kg (about 88 lbs). "Uncomplicated" means the infection is in the lower urinary tract (bladder) and the patient doesn't have complicating factors like kidney infection, structural abnormalities, or a catheter.

UTIs are one of the most common bacterial infections, and antibiotic resistance is a growing concern. Blujepa offers a new option, especially for patients who haven't responded to or can't take older antibiotics like Nitrofurantoin or Trimethoprim-Sulfamethoxazole.

2. Uncomplicated Urogenital Gonorrhea

As of December 2025, Blujepa is also approved for treating uncomplicated urogenital gonorrhea in patients 12 years and older weighing at least 45 kg. This approval is specifically for cases with limited or no alternative treatment options.

How Is Blujepa Taken?

Blujepa comes as 750 mg film-coated tablets. Here's how it's typically dosed:

For Uncomplicated UTIs:

• Dose: 1,500 mg (two 750 mg tablets) twice daily
• Duration: 5 days
• Total tablets: 10

For Uncomplicated Gonorrhea:

• Dose: 3,000 mg (four 750 mg tablets), then another 3,000 mg approximately 12 hours later
• Total tablets: 8

Important Instructions:

• Take after a meal to reduce stomach upset.
• Take doses about 12 hours apart.
• Complete the full course even if you start feeling better. Stopping early can lead to antibiotic resistance.

Who Should Not Take Blujepa?

Blujepa is not right for everyone. You should not take Blujepa if you have:

• A known severe allergy to Gepotidacin or any ingredient in Blujepa.
• Severe kidney impairment — Blujepa is not recommended for patients with severe renal issues.
• Severe liver impairment — Not recommended for patients with severe hepatic problems.

Use Blujepa with caution if you have:

• A history of QTc prolongation or heart rhythm problems
• Pre-existing heart disease
• A history of seizures

Always tell your doctor about all your medical conditions and medications before starting Blujepa. For a detailed list, see our guide on Blujepa drug interactions.

For information about possible side effects, read our article on Blujepa side effects.

How Much Does Blujepa Cost?

Because Blujepa is a brand-name medication with no generic alternative, it can be expensive:

• Cash price: $400–$600 for a 5-day UTI course (10 tablets)
• With insurance: Varies widely. Some plans cover it; others require prior authorization or step therapy (trying a cheaper antibiotic first).
• Medicare Part D: May be covered with formulary restrictions.

Ways to Save

• GSK copay savings card — Available for eligible commercially insured patients.
• GSK Patient Assistance Program (GSK For You) — For uninsured or underinsured patients. Apply at gskforyou.com or call 1-888-825-5249.
• Pharmacy discount cards — GoodRx, SingleCare, and others may offer savings.

For a comprehensive breakdown, see our complete guide to saving money on Blujepa.

Final Thoughts

Blujepa is an important new antibiotic option for patients with uncomplicated UTIs and gonorrhea. As a first-in-class drug, it works differently from existing antibiotics, which makes it especially valuable for patients dealing with antibiotic-resistant infections.

If you've been prescribed Blujepa, take it as directed, after meals, and for the full course. If cost or availability is a concern, Medfinder can help you find a pharmacy that has it in stock, and savings programs can help bring the price down.

Need to find Blujepa near you? Search on Medfinder.