Blisovi Fe 1/20 Is a Low-Dose Combination Birth Control Pill Used to Prevent Pregnancy and Treat Acne

If you've been prescribed Blisovi 21 Fe 1/20 28 Day Pack — or you're considering it — you probably have questions. What's in it? How do you take it? What does it cost? This guide covers everything you need to know in plain language.

What Is Blisovi Fe 1/20?

Blisovi Fe 1/20 is a combination hormonal contraceptive (birth control pill) that contains two active hormones:

• Norethindrone Acetate 1 mg — a progestin
• Ethinyl Estradiol 0.02 mg (20 mcg) — an estrogen

It's classified as a "low-dose" oral contraceptive because it contains only 20 micrograms of estrogen, compared to 30-35 mcg in standard-dose pills.

Key facts:

• Brand name: Blisovi Fe 1/20 is a generic equivalent of Loestrin Fe 1/20
• Manufacturer: Lupin Pharmaceuticals, Inc.
• Drug class: Combination Hormonal Contraceptive (Progestin/Estrogen)
• Controlled substance: No — Blisovi Fe 1/20 is not a controlled substance
• Generic available: Yes — Blisovi Fe 1/20 itself is a generic. Other equivalents include Junel Fe 1/20, Microgestin Fe 1/20, Larin Fe 1/20, and Gildess Fe 1/20.

What's in the Pack?

Each 28-day pack contains:

• 21 active yellow tablets: Norethindrone acetate 1 mg/ethinyl estradiol 0.02 mg
• 7 brown inactive tablets: Ferrous fumarate 75 mg (an iron supplement)

The "Fe" in the name stands for iron (ferrous fumarate). The brown tablets don't contain hormones — they're there to keep you in the habit of taking a daily pill and to provide a small iron supplement during your period.

What Is Blisovi Fe 1/20 Used For?

FDA-Approved Uses

• Prevention of pregnancy: The primary indication. When taken correctly, combination oral contraceptives are about 99% effective.
• Treatment of acne vulgaris: FDA-approved for moderate acne in females aged 15 and older who also want oral contraception.

Common Off-Label Uses

Doctors also prescribe Blisovi Fe 1/20 for conditions not listed on the official label:

• Regulation of irregular menstrual cycles
• Reducing heavy menstrual bleeding (menorrhagia)
• Relief from severe menstrual cramps (dysmenorrhea)
• Management of endometriosis-related pain
• Polycystic ovary syndrome (PCOS) symptom management

How Is Blisovi Fe 1/20 Taken?

Take one tablet daily at the same time every day for 28 days:

1. Days 1-21: Take one active yellow tablet daily
2. Days 22-28: Take one brown iron tablet daily
3. Day 29: Start a new pack immediately — do not skip any days between packs

Starting the pill:

• Sunday start: Begin your first pack on the first Sunday after your period starts. Use backup contraception (like condoms) for the first 7 days.
• Day 1 start: Begin on the first day of your period. No backup contraception needed.
• Follow your doctor's specific instructions for when to start.

Important tips:

• Take the pill at the same time every day to maintain consistent hormone levels
• Swallow the tablet whole — do not crush or chew
• If you miss a pill, refer to the patient information leaflet or call your doctor for guidance
• Vomiting or severe diarrhea within 3-4 hours of taking a pill may reduce its effectiveness

Who Should Not Take Blisovi Fe 1/20?

Blisovi Fe 1/20 is not safe for everyone. Do not take it if you have or have had:

• Blood clots (deep vein thrombosis or pulmonary embolism)
• Stroke or heart attack
• Heart valve disease with complications
• Uncontrolled high blood pressure
• Diabetes with vascular complications
• Migraines with aura
• Known or suspected breast cancer
• Liver disease or liver tumors
• Known or suspected pregnancy
• Current use of Hepatitis C medications containing ombitasvir/paritaprevir/ritonavir

Critical warning: Women over 35 who smoke must not use Blisovi Fe 1/20. Smoking combined with oral contraceptive use significantly increases the risk of heart attack, stroke, and blood clots.

For a detailed look at what side effects to watch for and what drug interactions to avoid, see our companion guides.

How Much Does Blisovi Fe 1/20 Cost?

The cost varies depending on your insurance and where you fill the prescription:

• With insurance: Most patients pay $0 under the ACA contraceptive mandate. Generic oral contraceptives are covered at no cost-sharing by most plans.
• Cash price (without insurance): $34 to $75 per 28-tablet pack
• With discount coupons: As low as $13 to $20 per pack using GoodRx, SingleCare, or other discount programs

There is no manufacturer savings program from Lupin Pharmaceuticals for Blisovi Fe 1/20, but third-party discount cards are widely available. For more ways to save, check our complete savings guide.

How Does Blisovi Fe 1/20 Compare to Similar Medications?

Blisovi Fe 1/20 is one of several generics of Loestrin Fe 1/20. They all contain the same active ingredients at the same doses:

• Junel Fe 1/20 — Same formulation, different manufacturer
• Microgestin Fe 1/20 — Same formulation, different manufacturer
• Larin Fe 1/20 — Same formulation, made by Northstar
• Gildess Fe 1/20 — Same formulation, different manufacturer
• Hailey Fe 1/20 — Same formulation, different manufacturer
• Aurovela Fe 1/20 — Same formulation, different manufacturer

These are all therapeutically equivalent, meaning they work the same way at the same doses. If Blisovi Fe 1/20 is unavailable, any of these can typically be substituted. Learn more about alternatives to Blisovi Fe 1/20.

A lower-dose option is Lo Loestrin Fe, which contains only 10 mcg of ethinyl estradiol (compared to 20 mcg in Blisovi Fe 1/20). It's available as a brand-name only.

Final Thoughts

Blisovi 21 Fe 1/20 28 Day Pack is a well-established, low-dose birth control pill that's been used safely by millions of women. It's effective for preventing pregnancy and treating acne, and it's available at low or no cost for most insured patients.

If you're looking to fill your prescription, Medfinder can help you find a pharmacy near you with Blisovi Fe 1/20 in stock. And if you have questions about how it works, side effects, or finding a prescriber, we've got guides for that too.