Upneeq Shortage Update: What's Happening in 2026?

If you've been struggling to find Upneeq at your pharmacy, you may be wondering: is Upneeq in shortage? The short answer is no — Upneeq is not currently listed on the FDA Drug Shortage Database. But that doesn't mean it's easy to find.

In this article, we'll give you the latest information on Upneeq availability in 2026, explain why it can be difficult to locate, break down current pricing, and share what you can do to get your prescription filled.

Is Upneeq Still in Shortage?

As of early 2026, Upneeq (Oxymetazoline Hydrochloride ophthalmic solution, 0.1%) is not in a formal drug shortage. The FDA Drug Shortage Database does not list Upneeq, and the manufacturer, RVL Pharmaceuticals, continues to produce and distribute the medication.

However, many patients report difficulty finding Upneeq at their local pharmacy. This is a real problem — but it's an availability and distribution issue, not a manufacturing shortage. For a deeper dive into why this happens, read our article on why Upneeq is so hard to find.

Why Is Upneeq Hard to Find?

There are several reasons Upneeq is difficult to locate, even though it's technically available:

Limited Distribution Model

Upneeq is distributed primarily through specialty pharmacies, eye care providers, and aesthetic clinics — not through the standard retail pharmacy supply chain. Most CVS, Walgreens, and Walmart locations do not routinely stock it.

Niche Indication

Upneeq treats acquired blepharoptosis (drooping eyelids), which is a real medical condition but affects a smaller population than common conditions like high blood pressure or diabetes. Lower demand means fewer pharmacies carry it.

Insurance Barriers

Many insurance plans don't cover Upneeq, or they require prior authorization. When patients can't afford the cash price, pharmacies may stop stocking it due to low sales volume.

Growing Awareness

Interest in Upneeq has been growing since its FDA approval in 2020, driven by social media and word-of-mouth. More patients are asking for it, but the supply chain hasn't fully expanded to meet demand at the retail pharmacy level.

How Much Does Upneeq Cost in 2026?

Understanding the cost picture is important when navigating availability:

• Cash price: $225 to $350 for a 30-count box (one month supply)
• With SingleCare coupon: Approximately $205
• With manufacturer savings card: Eligible commercially insured patients may pay as little as $0
• Insurance: Coverage varies widely. Many plans do not cover Upneeq, especially if they classify ptosis treatment as cosmetic. Some plans cover it with prior authorization when ptosis is documented to impair vision.

For a full breakdown of ways to save, check out our guide on how to save money on Upneeq in 2026.

Are There New Options in 2026?

As of early 2026, Upneeq remains the only FDA-approved prescription eye drop for acquired blepharoptosis. There is no generic version available. However, there are other approaches patients and doctors can consider:

• Surgical ptosis repair: A more permanent solution for moderate to severe cases, often covered by insurance when it affects vision.
• Off-label eye drops: Some doctors prescribe Phenylephrine or Brimonidine eye drops off-label for mild ptosis, though neither is FDA-approved for this indication.
• Eyelid crutches: Mechanical devices attached to eyeglasses that hold the eyelid open — a drug-free alternative.

For more detail on each option, read our article on alternatives to Upneeq.

How to Find Upneeq in Stock

If you need Upneeq, here are the most effective strategies for finding it:

1. Check Medfinder

Medfinder lets you search for pharmacies near you that have Upneeq in stock. It's faster and easier than calling pharmacies one by one.

2. Contact Your Eye Doctor

Many ophthalmologists, optometrists, and oculoplastic surgeons who prescribe Upneeq also dispense it from their office or have preferred specialty pharmacies. Ask your prescriber for recommendations.

3. Try Specialty Pharmacies

Specialty and independent pharmacies are much more likely to carry Upneeq than major chain pharmacies. Search for specialty pharmacies in your area or ask your doctor for a referral.

4. Use Telehealth

Telehealth platforms can provide a consultation and ship Upneeq directly to your door. This can be ideal for patients in areas with limited pharmacy options. Learn more in our guide to finding a doctor who can prescribe Upneeq.

5. Verify Stock Before You Go

Before making a trip to the pharmacy, call ahead or use our guide on checking pharmacy stock to confirm Upneeq is available at your location. This saves time and frustration.

Final Thoughts

Upneeq is not in shortage, but its limited distribution can make it feel like it is. The key takeaway for 2026: Upneeq is available — you just may need to look beyond your local chain pharmacy to find it.

Use Medfinder to check availability, talk to your eye doctor about where to get it, and explore telehealth options if local access is limited. And if cost is a barrier, don't miss our article on saving money on Upneeq.