Upneeq can cost $225–$350/month without insurance. Learn how to save with coupons, discount cards, manufacturer programs, and patient assistance.
Upneeq (Oxymetazoline Hydrochloride ophthalmic solution, 0.1%) is the only FDA-approved prescription eye drop for acquired blepharoptosis — drooping upper eyelids. It's an effective treatment, but the price can be a barrier. Without insurance, a 30-day supply of Upneeq typically costs between $225 and $350.
The good news? There are several ways to bring that cost down. In this guide, we'll walk through every major savings option available to Upneeq patients in 2026, including coupons, discount cards, manufacturer programs, and patient assistance.
Let's start with the baseline numbers:
These prices apply when paying entirely out of pocket, without insurance or any discount programs. That's roughly $2,700 to $4,200 per year — a significant expense for a medication you use daily.
Prescription discount cards are one of the easiest ways to save on Upneeq. These programs are free to use and don't require insurance. Here are some of the best options:
SingleCare consistently offers one of the best prices for Upneeq. As of 2026, the SingleCare price for Upneeq is approximately $205 for a 30-count box — a savings of about $70 off the average cash price. You can get a free SingleCare coupon at singlecare.com and use it at most major pharmacies, including Walgreens, CVS, Walmart, and Kroger (where available).
GoodRx is another popular option for prescription savings. GoodRx prices for Upneeq vary by pharmacy and location but may offer similar or slightly different savings compared to SingleCare. Check goodrx.com/upneeq for current pricing in your area.
Several other discount card programs may offer Upneeq savings:
Prices can vary between programs and pharmacies, so it's worth comparing a few options before filling your prescription. A few minutes of research can save you $50 to $100 per month.
RVL Pharmaceuticals, the maker of Upneeq, offers a savings program for eligible patients. Here are the key details:
If you have commercial insurance — even if your plan doesn't cover Upneeq — the manufacturer savings card may still help reduce your out-of-pocket cost significantly. Always ask your doctor or pharmacist about this option.
Insurance coverage for Upneeq is inconsistent. Here's what you should know:
Some commercial plans cover Upneeq, often with prior authorization. Your doctor will need to document that:
If your plan covers Upneeq, your copay could range from $30 to $75 per fill, depending on your plan's specialty drug tier. The manufacturer savings card can often be stacked on top of insurance to further reduce your copay.
Medicare Part D coverage for Upneeq is limited. Many Medicare plans do not include Upneeq on their formulary. If yours does, expect a higher-tier copay. Unfortunately, the manufacturer savings card cannot be used with Medicare.
Medicaid coverage varies by state. Some state Medicaid programs may cover Upneeq; others will not. Contact your state's Medicaid program or ask your pharmacy to check.
If your insurance denies coverage for Upneeq, you have the right to appeal. Ask your doctor's office to submit an appeal with supporting documentation (visual field tests, clinical photos, diagnosis codes). Some patients successfully obtain coverage after an initial denial.
If you are uninsured or underinsured, patient assistance programs (PAPs) may help you get Upneeq at little or no cost:
Contact RVL Pharmaceuticals directly through their website (upneeq.com) to inquire about patient assistance options for qualifying patients who cannot afford Upneeq.
The following organizations maintain databases of patient assistance programs and may have information relevant to Upneeq:
Beyond the main savings options above, here are a few more strategies:
Upneeq pricing can vary significantly between pharmacies — sometimes by $50 to $100 or more for the same product. Use Medfinder to find pharmacies that stock Upneeq near you, then compare prices using discount card tools.
Your eye doctor's office may have sample packs of Upneeq from the manufacturer. Samples can give you a chance to try the medication before committing to a full month's purchase.
Some pharmacies or providers may offer a small discount for purchasing multiple months at once. Ask if a 90-day supply option is available and whether it comes with a reduced per-unit price.
Some telehealth platforms that prescribe and ship Upneeq offer bundled pricing that includes the consultation fee and medication in one package. This can sometimes be more cost-effective than a separate doctor visit plus pharmacy fill.
Upneeq is a valuable treatment for acquired ptosis, but the cost can be challenging — especially without insurance coverage. The most important step you can take is to not pay full price without first exploring your options. Between manufacturer savings cards, discount programs like SingleCare and GoodRx, and patient assistance programs, most patients can find a way to make Upneeq more affordable.
Start by checking the manufacturer savings program at upneeq.com. Then compare prices using discount cards. And if you're struggling to find Upneeq at all, visit Medfinder to locate a pharmacy near you, or read our guide on how to find Upneeq in stock. For more about the medication itself, see What is Upneeq?
You focus on staying healthy. We'll handle the rest.
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