Upneeq Is a Prescription Eye Drop That Lifts Droopy Eyelids Without Surgery

Upneeq (Oxymetazoline Hydrochloride ophthalmic solution, 0.1%) is the first and only FDA-approved prescription eye drop for the treatment of acquired blepharoptosis — droopy upper eyelids — in adults. It offers a non-surgical way to temporarily lift the upper eyelid, improving both appearance and, in some cases, the field of vision.

If you're considering Upneeq or just want to understand what it is, this guide covers everything: how it works, what it's used for, how to take it, who shouldn't use it, and what it costs in 2026.

What Is Upneeq?

Here are the basics:

• Brand name: Upneeq
• Generic name: Oxymetazoline Hydrochloride ophthalmic solution, 0.1%
• Drug class: Alpha-adrenergic agonist (ophthalmic)
• Manufacturer: RVL Pharmaceuticals, Inc.
• FDA approval: Approved for acquired blepharoptosis in adults
• Controlled substance: No — Upneeq is not a controlled substance
• Generic available: No generic version is available as of 2026

Upneeq comes as a sterile ophthalmic solution in single-use containers. Each box contains 30 individual child-resistant foil pouches, with each pouch holding a 0.3 mL single-use vial — enough for one day's dose.

What Is Upneeq Used For?

FDA-Approved Use

Upneeq is approved for the treatment of acquired blepharoptosis in adults. Blepharoptosis (often just called "ptosis") is a condition where the upper eyelid droops lower than normal. "Acquired" means it developed over time rather than being present at birth. It can be caused by aging, nerve damage, muscle weakness, or previous eye surgery.

Ptosis can range from a barely noticeable droop to a significant sag that partially blocks your vision.

Off-Label Uses

Some providers prescribe Upneeq for:

• Cosmetic eyelid lift: Even people without a clinical ptosis diagnosis use Upneeq for a subtle, refreshed look — wider-appearing eyes without surgery.
• Low-lying lids causing visual obstruction: In borderline cases where ptosis isn't severe enough for surgery but still interferes with daily tasks.

How Is Upneeq Taken?

Using Upneeq is straightforward:

1. Wash your hands before handling the vial.
2. Open one single-use container by peeling back the foil pouch.
3. Tilt your head back and pull down your lower eyelid to create a small pocket.
4. Instill one drop into the affected eye(s).
5. Close your eye gently for a moment to allow the drop to absorb.
6. Discard the vial after use — do not save it for later.

Important Usage Notes

• Frequency: One drop in the affected eye(s), once daily.
• Contact lenses: Remove contacts before applying Upneeq. Wait at least 15 minutes before reinserting.
• Other eye drops: If you use other eye medications, space them at least 15 minutes apart.
• Don't touch the tip: Avoid letting the vial tip touch your eye, fingers, or any surface to prevent contamination.

For more on how the medication works inside your body, read How Does Upneeq Work? Mechanism of Action Explained.

Who Should Not Take Upneeq?

Upneeq is not right for everyone. You should not use Upneeq if you have a known allergy to Oxymetazoline or any ingredient in the formulation.

Use Upneeq with caution if you have:

• Severe or unstable cardiovascular disease
• Uncontrolled high or low blood pressure
• Orthostatic hypotension (dizziness when standing up)
• Cerebral or coronary insufficiency
• Sjögren's syndrome
• Untreated narrow-angle glaucoma (risk of acute angle closure)

Always tell your doctor about all of your medical conditions and medications before starting Upneeq. For a full list of potential drug interactions, see our guide on Upneeq drug interactions.

Pregnancy and Breastfeeding

It's unknown whether Upneeq can harm a developing fetus or pass into breast milk. If you're pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor.

How Much Does Upneeq Cost?

Without insurance, Upneeq typically costs between $225 and $350 for a 30-count box (a one-month supply). There is no generic version available, which keeps the price high.

Insurance Coverage

Coverage varies widely. Many insurance plans do not cover Upneeq, especially if they classify it as cosmetic. Some plans may cover it with prior authorization if your doctor documents that ptosis is obstructing your vision. Medicare Part D plans generally do not cover it.

Ways to Save

• Manufacturer savings program: RVL Pharmaceuticals offers a savings card through upneeq.com. Eligible commercially insured patients may pay as little as $0.
• Discount cards: Platforms like GoodRx, SingleCare, and RxSaver may offer reduced cash prices at participating pharmacies.
• Patient assistance: If you're uninsured or underinsured, check NeedyMeds.org or RxAssist.org for programs that may help cover the cost.

For a complete breakdown of savings options, read our guide to saving money on Upneeq.

Final Thoughts

Upneeq is a first-of-its-kind treatment that gives adults with droopy eyelids a non-surgical option. One drop, once a day, can temporarily lift your upper eyelid and improve your appearance or field of vision. It's generally well-tolerated, though it's important to know the side effects and discuss your medical history with your doctor before starting.

If you're ready to try Upneeq, the next step is finding a provider who prescribes it. Check out our guide on how to find a doctor who can prescribe Upneeq, and use Medfinder to find a pharmacy with it in stock.