Relagard Side Effects: What to Expect and When to Call Your Doctor

Relagard (acetic acid 0.9% / oxyquinoline 0.025% vaginal gel) is generally well-tolerated by most patients. Because it is applied locally in the vagina and has minimal systemic absorption, side effects tend to be mild and localized. That said, it's important to know what's normal, what may improve over time, and what warrants a call to your doctor.

Common Side Effects of Relagard

The most frequently reported side effects with Relagard are localized reactions at the application site. These are generally mild and often improve as your body adjusts to the medication:

Burning or stinging: The most common reaction, especially right after application. This is typically brief and mild. The acetic acid component is acidic by nature, which can cause a slight burning sensation on sensitive tissue.

Mild vaginal irritation: Some patients notice mild itching or discomfort, particularly at the beginning of treatment.

Discharge changes: The gel itself may alter vaginal discharge temporarily. This is expected and not a cause for concern.

When Side Effects Usually Appear and Resolve

Burning and stinging tend to be most noticeable immediately after insertion of the applicator and usually subside within a few minutes. If you find the initial application uncomfortable, using Relagard at bedtime (when you're lying down and less active) can minimize the sensation. Most users report that localized irritation, if it occurs, improves after the first few days of use as the vaginal tissue adjusts.

Serious Side Effects: Stop Using Relagard and Call Your Doctor If:

While rare, serious reactions can occur. Seek medical attention promptly if you experience any of the following:

Severe burning, stinging, or irritation — significantly worse than mild discomfort, or that doesn't subside after the first few minutes post-application

Signs of allergic reaction: Rash, hives, itching, swollen or blistered skin, wheezing, difficulty breathing or swallowing, unusual hoarseness, or swelling of the face, lips, tongue, or throat

Worsening vaginal symptoms: If your vaginal condition gets worse rather than better after using Relagard, contact your healthcare provider. Your symptoms may indicate a different underlying condition requiring different treatment.

Accidental Ingestion or Eye Contact

Relagard is for vaginal use only. Keep it away from your eyes, nose, and mouth, as the acetic acid can cause burning and irritation on contact. If eye contact occurs, rinse thoroughly with cool water. An overdose through vaginal application is not expected to be dangerous, but if the product is accidentally swallowed, call Poison Control at 1-800-222-1222.

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Does Relagard Have a Boxed Warning?

No — Relagard does not carry an FDA boxed warning (the most serious warning category). Given that it has limited systemic absorption and well-understood ingredients, it is considered a low-risk medication for most patients when used as directed.

Pregnancy and Breastfeeding Considerations

It is not known whether Relagard will harm an unborn baby or whether the active ingredients pass into breast milk in clinically significant amounts. Because adequate safety studies in pregnancy have not been conducted, Relagard is generally not recommended during pregnancy or breastfeeding unless your healthcare provider determines that the benefits outweigh the potential risks. Always tell your doctor if you are pregnant, planning to become pregnant, or nursing before starting Relagard.

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Tips to Minimize Discomfort When Using Relagard

Apply at bedtime to allow the gel to work while you sleep, minimizing leakage and discomfort during activity

Use an unscented, deodorant-free pad or panty liner (not a tampon) to prevent staining

Wear loose-fitting, cotton underwear to allow airflow during treatment

Wash your hands thoroughly before and after application

For more on what to avoid while using Relagard, see our guide to Relagard drug interactions.