Get the latest Posaconazole shortage update for 2026. Learn which formulations are affected, what's causing supply issues, and how patients can cope.
If you depend on Posaconazole (brand name Noxafil) to protect against dangerous fungal infections, you may have noticed that getting your prescription filled has become more challenging. This article provides an up-to-date look at the Posaconazole shortage situation in 2026, explains what's causing it, and offers practical advice for patients.
Posaconazole is available in several formulations, and the supply situation differs for each:
The delayed-release tablets are the most commonly prescribed oral form of Posaconazole. As of early 2026, generic delayed-release tablets are generally available from multiple manufacturers, though periodic spot shortages have been reported at individual pharmacies. If your local pharmacy is out of stock, other pharmacies in your area may have it.
The original immediate-release (IR) oral suspension of Posaconazole (40 mg/mL) was removed from the market in 2024. This was a significant change because many patients — particularly children and adults who have difficulty swallowing tablets — relied on this formulation.
A newer product called Noxafil PowderMix (powder for delayed-release oral suspension) has been introduced as a replacement. However, it has different dosing than the old suspension, and availability may still be limited in some areas.
The IV formulation is primarily used in hospitals and is generally available for inpatient use. Supply of the IV formulation has been more stable than oral forms.
Several factors contribute to the current supply challenges:
When the original oral suspension was removed from the market in 2024, it created a gap for patients who needed a liquid formulation. The transition to the PowderMix has been gradual, and not all pharmacies have adapted.
While generic Posaconazole delayed-release tablets exist, the number of manufacturers is limited compared to more commonly prescribed drugs. Manufacturing issues at even one facility can cause regional supply disruptions.
Posaconazole is a complex molecule to synthesize, and the delayed-release tablet formulation requires specialized manufacturing processes. This makes it harder for new generic manufacturers to enter the market quickly.
Posaconazole is used primarily by immunocompromised patients — a relatively small but growing population. Pharmaceutical supply chains aren't always optimized for medications with smaller patient bases, which can lead to uneven distribution.
The Posaconazole shortage can impact patients in several ways:
Use MedFinder to search for pharmacies near you that have Posaconazole in stock. This is the fastest way to check multiple pharmacies at once. For a step-by-step guide, see: How to Find Posaconazole in Stock Near You.
Let your doctor, nurse practitioner, or pharmacist know you're having trouble finding Posaconazole. They can:
Don't wait until you're out of Posaconazole to seek a refill. Request refills at least one week before you run out. This gives you time to find an alternate pharmacy if your usual one is out of stock.
If you previously used the discontinued oral suspension, ask your doctor about the Noxafil PowderMix delayed-release oral suspension. It's designed for patients who need a liquid form, though the dosing is different from the old suspension.
If cost is adding to your access problems, there are programs that can help. Merck offers a patient assistance program for Noxafil, and discount cards from GoodRx and SingleCare can significantly reduce the cost of generic Posaconazole. Learn more in our guide to saving money on Posaconazole.
Stay informed about the Posaconazole shortage through these reliable sources:
If you've been unable to fill your Posaconazole prescription for more than a few days, contact your doctor right away. Going without antifungal prophylaxis can put you at risk for serious infections. Your doctor may consider switching you to an alternative such as:
For a detailed comparison of alternatives, see: Alternatives to Posaconazole If You Can't Fill Your Prescription.
The Posaconazole shortage in 2026 is a real challenge, but it's manageable with the right approach. Stay proactive: use tools like MedFinder to locate pharmacies with stock, communicate openly with your healthcare team, plan ahead on refills, and know your alternatives. Your health depends on consistent antifungal protection, and you deserve help finding it.
Related articles:
You focus on staying healthy. We'll handle the rest.
Try Medfinder Concierge FreeMedfinder's mission is to ensure every patient gets access to the medications they need. We believe this begins with trustworthy information. Our core values guide everything we do, including the standards that shape the accuracy, transparency, and quality of our content. We’re committed to delivering information that’s evidence-based, regularly updated, and easy to understand. For more details on our editorial process, see here.
%2C%20Color%3DOriginal.png)
