What You Need to Know About Phexx Drug Interactions

One of the advantages of Phexx is that it has very few drug interactions compared to systemic medications like birth control pills. Because Phexx works locally in the vagina rather than being absorbed into your bloodstream, it doesn't interact with most oral medications, supplements, or foods.

That said, there are a few important interactions and precautions to be aware of. This guide covers everything you need to know.

How Drug Interactions Work

Drug interactions happen when one medication affects how another medication works. This can mean one drug becomes less effective, more potent, or causes unexpected side effects.

With systemic medications (pills, injections), interactions are common because drugs travel through your bloodstream and can affect each other in the liver, kidneys, or other organs.

Phexx is different. It's a topical vaginal gel that stays in the vaginal canal. It isn't significantly absorbed into your bloodstream, which means it doesn't interact with most medications the way oral drugs do. However, it can interact with other products used vaginally.

Medications That Interact With Phexx

Vaginal Rings — Do Not Use Together

The most important drug interaction for Phexx is with vaginal rings (such as NuvaRing or Annovera). Phexx should not be used at the same time as a vaginal ring.

Why? Vaginal rings release hormones that are absorbed through the vaginal wall. The acidic ingredients in Phexx could potentially alter the absorption or effectiveness of these hormones. The FDA labeling for Phexx specifically states that it should not be used with vaginal rings.

If you currently use a vaginal ring for contraception, talk to your doctor before switching to or adding Phexx.

Other Vaginal Products

While not a formal drug interaction, it's worth being cautious about using Phexx alongside other vaginal products, including:

• Vaginal antifungal creams or suppositories (e.g., Miconazole, Clotrimazole) — If you're treating a yeast infection, it may be best to wait until treatment is complete before using Phexx. The combination could increase irritation.
• Vaginal moisturizers or lubricants — These could dilute Phexx or alter its pH-buffering ability. Ask your doctor or pharmacist whether your specific product is safe to use alongside Phexx.
• Vaginal antibiotics (e.g., Metronidazole vaginal gel for bacterial vaginosis) — Coordinate timing with your doctor to avoid using both products simultaneously.

Supplements and Over-the-Counter Products

Because Phexx acts locally and is not absorbed systemically, it does not interact with:

• Oral vitamins and supplements
• Over-the-counter pain relievers (Ibuprofen, Acetaminophen, Aspirin)
• Antihistamines, decongestants, or cold medicines
• Probiotics (including vaginal probiotics, though timing should be separated)

There are no known interactions between Phexx and oral supplements or OTC medications.

Food and Drink Interactions

Phexx has no known food or drink interactions. Because it's applied vaginally and not taken by mouth, what you eat or drink does not affect how Phexx works.

What to Tell Your Doctor Before Starting Phexx

Even though Phexx has minimal drug interactions, you should always give your doctor a complete picture of your health. Tell them about:

• All medications you're currently taking — including prescription drugs, OTC medications, and supplements
• Any vaginal products you use — including lubricants, moisturizers, or other contraceptives
• Whether you use a vaginal ring — this is the most important interaction to flag
• History of recurrent UTIs — Phexx is contraindicated in people with recurrent UTIs
• Known allergies — especially to Lactic Acid, Citric Acid, or Potassium Bitartrate
• Pregnancy or plans to become pregnant — Phexx should be discontinued if pregnancy occurs
• Breastfeeding status — there is no data on Phexx in breast milk

Can Phexx Be Used With Other Contraceptives?

Yes — with one exception. Phexx can be safely combined with:

• Male condoms — Yes, and this provides dual protection
• Female condoms — Yes
• Diaphragms — Generally yes, though discuss with your doctor
• Oral contraceptives (the pill) — Yes, no interaction
• Hormonal IUDs or copper IUDs — Yes, no interaction
• Implants (Nexplanon) — Yes, no interaction
• Injectable contraceptives (Depo-Provera) — Yes, no interaction

The only contraceptive you cannot use with Phexx is a vaginal ring.

Final Thoughts

Phexx has one of the simplest drug interaction profiles of any contraceptive. The main thing to remember: don't use it with a vaginal ring. Beyond that, Phexx doesn't interact with oral medications, supplements, or foods.

If you're considering Phexx, talk to your doctor about your full medication list, especially any vaginal products you use. For more about what Phexx is and how it works, check out our other guides.

Ready to fill your prescription? Use Medfinder to find Phexx in stock near you.