Junel Fe 1.5/30 28 Day Side Effects: What to Expect and When to Call Your Doctor

Updated:

February 24, 2026

Author:

Peter Daggett

Summarize this blog with AI:

Learn about common and serious side effects of Junel Fe 1.5/30 28 Day, how to manage them, and when you should call your doctor right away.

Junel Fe 1.5/30 28 Day Side Effects: What You Should Know

Every medication comes with potential side effects, and Junel Fe 1.5/30 28 Day is no exception. The good news is that most side effects are mild and tend to improve within the first few months of use. But it's important to know which symptoms are normal and which ones mean you should call your doctor right away.

This guide covers the common side effects, the serious warning signs, and practical tips for managing how you feel while taking Junel Fe 1.5/30 28 Day.

What Is Junel Fe 1.5/30 28 Day?

Junel Fe 1.5/30 28 Day is a combination oral contraceptive that contains two hormones — norethindrone acetate (a progestin) and ethinyl estradiol (an estrogen) — plus iron tablets for the last 7 days of each pack. It's used primarily to prevent pregnancy and is also approved to treat acne in women 15 and older. For a deeper look at how it works, see our guide on Junel Fe 1.5/30 28 Day's mechanism of action.

Common Side Effects

These side effects are the most frequently reported by women taking Junel Fe 1.5/30 28 Day. They're usually mild and often go away on their own within 2 to 3 months as your body adjusts:

  • Nausea — One of the most common complaints, especially in the first few weeks. Taking your pill with food or at bedtime can help.
  • Breakthrough bleeding or spotting — Light bleeding between periods is normal during the first 1 to 3 months. It doesn't mean the pill isn't working.
  • Breast tenderness — Your breasts may feel sore or swollen, particularly in the first cycle or two.
  • Headaches — Mild headaches are common. If they become severe or frequent, talk to your doctor.
  • Bloating — Some water retention is normal and usually mild.
  • Weight changes — Slight weight gain (usually 1 to 3 pounds from water retention) may occur. Significant weight gain is uncommon.
  • Mood changes — Some women notice mood swings, irritability, or increased anxiety.
  • Decreased libido — A lower sex drive affects some women on combination pills.
  • Acne changes — Your skin may initially break out before improving. Junel Fe 1.5/30 28 Day is actually approved to treat acne over time.
  • Vomiting — Less common than nausea, but may occur. If you vomit within 2 hours of taking your pill, use backup contraception.

Serious Side Effects

Serious side effects from Junel Fe 1.5/30 28 Day are rare, but they can be life-threatening. Call your doctor or go to the emergency room immediately if you experience any of the following:

Blood Clots

Combination oral contraceptives increase the risk of blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). Warning signs include:

  • Sudden swelling, warmth, or pain in one leg
  • Sudden shortness of breath or chest pain
  • Coughing up blood

Stroke

Seek emergency care if you experience:

  • Sudden severe headache unlike any you've had before
  • Sudden weakness or numbness on one side of your body
  • Sudden trouble speaking or understanding speech
  • Sudden vision changes

Heart Attack

Watch for:

  • Chest pain or pressure
  • Pain spreading to your arm, jaw, or back
  • Shortness of breath, sweating, or nausea

Other Serious Side Effects

  • Liver problems — Yellowing of the skin or eyes (jaundice), dark urine, severe abdominal pain
  • High blood pressure — Your doctor should check your blood pressure regularly while you're on the pill
  • Severe depression — If you develop significant mood changes or thoughts of self-harm, contact your doctor immediately
  • Gallbladder disease — Severe abdominal pain, especially on the right side
  • Severe allergic reaction — Hives, swelling of the face or throat, difficulty breathing
⚠️ Black Box Warning: Cigarette smoking increases the risk of serious cardiovascular side effects from oral contraceptives. This risk increases with age and the number of cigarettes smoked. Women over 35 who smoke should NOT use Junel Fe 1.5/30 28 Day.

Who Is at Higher Risk for Serious Side Effects?

Certain groups face a higher risk of serious complications from combination oral contraceptives:

  • Women over 35 who smoke — Significantly increased risk of blood clots, stroke, and heart attack
  • Women with migraine with aura — Higher stroke risk; should not use combination pills
  • Women with a history of blood clots — Should not take Junel Fe 1.5/30 28 Day
  • Women with uncontrolled high blood pressure — Risk of cardiovascular events increases
  • Women who are pregnant or breastfeeding — Junel Fe 1.5/30 28 Day should not be used during pregnancy. If you're breastfeeding, talk to your doctor about progestin-only options.

For a full list of who should not take this medication, see our post on what Junel Fe 1.5/30 28 Day is and who should avoid it.

How to Manage Common Side Effects

Most side effects improve with time, but here are some practical tips:

  • For nausea: Take your pill with food or right before bed.
  • For breakthrough bleeding: Be patient — it usually resolves within 3 months. Don't stop taking the pill. Make sure you're taking it at the same time every day.
  • For headaches: Over-the-counter pain relievers like acetaminophen or ibuprofen can help. Stay hydrated.
  • For bloating: Reduce salt intake and drink plenty of water.
  • For mood changes: Track your moods for a few months. If they don't improve, talk to your doctor about switching to a different formulation.
  • For decreased libido: This may improve over time. If it doesn't, a pill with a different progestin type may work better for you.

If side effects are bothering you after 3 months, don't just stop taking your pill — talk to your doctor about alternative contraceptive options that may suit you better.

It's also worth knowing that certain drug interactions can affect how Junel Fe 1.5/30 28 Day works or increase the chance of side effects.

Final Thoughts

Junel Fe 1.5/30 28 Day is a safe and effective birth control option for most women. Mild side effects like nausea, spotting, and breast tenderness are common early on but usually improve within a few months. Serious side effects are rare but important to recognize.

If you experience any warning signs of blood clots, stroke, or heart attack, seek emergency medical care immediately. And if common side effects aren't improving, talk to your doctor — there are plenty of alternatives to try.

If you need help finding Junel Fe 1.5/30 28 Day at a pharmacy near you, Medfinder can help you check stock availability in real time.

What are the most common side effects of Junel Fe 1.5/30 28 Day?

The most common side effects include nausea, breakthrough bleeding or spotting, breast tenderness, headaches, bloating, weight changes, and mood changes. These typically improve within the first 2 to 3 months of use.

When should I call my doctor about side effects from Junel Fe 1.5/30 28 Day?

Call your doctor or seek emergency care if you experience signs of blood clots (leg swelling, chest pain, shortness of breath), stroke symptoms (sudden severe headache, weakness on one side), jaundice, or severe depression. These are rare but serious.

Does Junel Fe 1.5/30 28 Day cause weight gain?

Some women experience slight weight gain (1 to 3 pounds), usually from water retention rather than fat gain. Significant weight gain is uncommon. If you notice substantial changes, talk to your doctor.

How long do side effects from Junel Fe 1.5/30 28 Day last?

Most common side effects like nausea, spotting, and breast tenderness improve within the first 2 to 3 months as your body adjusts to the hormones. If side effects persist beyond 3 months, talk to your doctor about alternatives.

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