Hyperrho Shortage in 2026: The Latest Update

If you're Rh-negative and pregnant — or planning to become pregnant — the ongoing Hyperrho shortage has probably been on your radar. Rho(D) immune globulin is one of those medications you absolutely cannot skip, and the uncertainty around supply has been stressful for patients and providers alike.

Here's what we know about the Hyperrho shortage as of early 2026, including what's causing it, what it costs, and how to find it.

Is Hyperrho Still in Shortage?

The short answer: supply remains constrained but is improving. Rho(D) immune globulin products — including Hyperrho (HyperRHO S/D), RhoGAM, WinRho SDF, and Rhophylac — have experienced intermittent shortages since 2023. The FDA has periodically listed various Rho(D) immune globulin products on its official drug shortage list.

As of early 2026, the situation is better than it was at the peak of the shortage in 2024, but Hyperrho specifically can still be difficult to find at many pharmacies. Availability varies significantly by region — some areas have consistent supply while others still face gaps.

Why Is Hyperrho Hard to Find?

The Hyperrho shortage comes down to a few key factors:

• Limited donor plasma: Hyperrho is made from the plasma of Rh-negative donors who have been sensitized to the Rh(D) antigen. This is a very small donor pool, and plasma collections have not kept pace with demand.
• Lengthy manufacturing: Plasma fractionation — the process of turning raw plasma into a finished injectable product — takes 7 to 12 months. Manufacturers can't quickly ramp up production.
• Few manufacturers: Only a handful of companies worldwide produce Rho(D) immune globulin, so any disruption at one facility can ripple through the entire market.
• Growing global demand: More countries are implementing routine Rh immunoprophylaxis, increasing competition for the same limited supply.

For a deeper dive, read our article on why Hyperrho is so hard to find.

What Does Hyperrho Cost in 2026?

Hyperrho pricing varies depending on where you get it and whether you have insurance:

• Cash price (Full Dose, 300 mcg): Approximately $150–$350 per dose
• Cash price (Mini-Dose, 50 mcg): Approximately $100–$200 per dose
• With insurance: Most insurance plans cover Rho(D) immune globulin under the medical benefit (not pharmacy benefit) when administered in a clinical setting. Your out-of-pocket cost may be $0–$50 with good coverage, or more if you haven't met your deductible.

Because Hyperrho is a plasma-derived biologic, there are no true generics and prices remain relatively high across all brands. For tips on reducing your costs, see our guide on how to save money on Hyperrho.

Are There New Options in 2026?

The Rho(D) immune globulin market hasn't seen a brand-new product enter the U.S. market recently, but there are developments worth noting:

• Expanded production: Existing manufacturers have been working to increase plasma collection and manufacturing capacity. Grifols, Kedrion Biopharma, and CSL Behring have all announced investments in production.
• Alternative products: If Hyperrho is unavailable, RhoGAM, WinRho SDF, and Rhophylac remain viable alternatives. All contain the same active ingredient.
• Research: Some researchers are exploring recombinant (non-plasma-derived) anti-D antibodies, which could eventually eliminate the dependency on human plasma donors. However, these products are still in development and not yet available.

How to Find Hyperrho in Stock

Here are the most effective strategies for locating Hyperrho or an equivalent product:

1. Search on Medfinder: Use Medfinder to check real-time pharmacy availability near your zip code.
2. Call independent pharmacies: They often have different supply chains than the big chains and may have stock when others don't.
3. Ask your OB-GYN: Many obstetric practices keep Rho(D) immune globulin in the office and administer it directly — no pharmacy visit needed.
4. Check hospital pharmacies: Hospital outpatient pharmacies and labor and delivery units typically maintain their own supply.
5. Be flexible on brand: If your doctor writes for "Rho(D) immune globulin" rather than a specific brand, the pharmacy can fill with whatever product is in stock.

For more detailed strategies, read our full guide on how to find Hyperrho in stock near you.

Final Thoughts

The Hyperrho shortage has been a challenging situation for Rh-negative patients, but supply is trending in the right direction. The most important thing is that you receive Rho(D) immune globulin on schedule — whether it's Hyperrho, RhoGAM, or another brand.

Stay proactive: search on Medfinder, talk to your doctor early, and have a backup plan. For the latest information on your specific medication, check back here or visit our pages on what Hyperrho is and Hyperrho side effects.