Hyperrho can cost $150-$350 per dose. Learn how to save with patient assistance programs, insurance tips, and other strategies in 2026.
If you've been told you need Hyperrho (HyperRHO S/D) during your pregnancy, you might be wondering what it's going to cost you. Especially if you're uninsured, underinsured, or facing a high deductible, the price tag can feel daunting on top of everything else pregnancy throws at you.
In this guide, we'll break down exactly what Hyperrho costs in 2026, and walk you through every option for bringing that price down — from insurance strategies to patient assistance programs.
Hyperrho is a plasma-derived biologic, which means it's inherently expensive to manufacture. Here's what you can expect to pay out of pocket:
Most patients need two full doses during pregnancy — one at 28 weeks and one after delivery — bringing the total potential cost to $300–$700 without insurance. Additional doses may be needed after miscarriage, ectopic pregnancy, amniocentesis, or other events.
Because Hyperrho is a biologic made from human plasma, there is no generic version. All Rho(D) immune globulin products — including RhoGAM, WinRho SDF, and Rhophylac — are brand-name products with similar pricing.
Yes — most insurance plans cover Rho(D) immune globulin, but the details matter.
This is the most important distinction. When Hyperrho is administered in a doctor's office, hospital, or clinic, it's typically billed under your medical benefit — the same way a procedure or office visit is billed. This is the most common scenario and usually results in better coverage.
When filled at a retail pharmacy, it may fall under your pharmacy benefit, which could mean different copays, coinsurance, or formulary restrictions.
Most insurance plans do not require prior authorization for Rho(D) immune globulin when used for standard obstetric indications (Rh immunoprophylaxis). However, if used for an off-label indication, prior auth may be required.
Traditional pharmacy discount cards (like GoodRx, SingleCare, or RxSaver) have limited utility for Hyperrho because:
That said, if you are filling a prescription at a retail pharmacy, it's worth checking these tools:
Even with a discount card, expect to pay in the range of $100–$300 for a full dose. Discounts on biologics tend to be more modest than on traditional generic drugs.
If you're uninsured or facing financial hardship, patient assistance programs (PAPs) may provide Hyperrho at reduced cost or even free of charge.
Grifols, the manufacturer of Hyperrho, offers a patient assistance program for eligible patients. Eligibility typically requires:
Contact Grifols directly to apply. Their customer service team can walk you through the application process and eligibility requirements.
NeedyMeds is a nonprofit that maintains a database of patient assistance programs, including those for immune globulin products. Search for "Rho(D) immune globulin" or "Hyperrho" on their website to find current programs.
RxAssist is another comprehensive database of patient assistance programs. It's particularly useful for finding programs you might not discover through a simple web search.
RxHope helps connect patients with manufacturer assistance programs and can simplify the application process.
Getting Hyperrho at your doctor's office rather than a retail pharmacy can save money in several ways:
Many OB-GYN practices are set up to administer Rho(D) immune globulin on-site as part of routine prenatal care.
If Hyperrho is priced higher than other options at your pharmacy, ask about switching to RhoGAM, WinRho SDF, or Rhophylac. Pricing varies by brand and pharmacy, and one product may be significantly cheaper than another at a given location. For details, see our guide on alternatives to Hyperrho.
If you're receiving care at a hospital, ask about their financial assistance or charity care programs. Many hospitals have programs that can reduce or eliminate costs for patients who qualify based on income.
If you have a Health Savings Account (HSA) or Flexible Spending Account (FSA), Rho(D) immune globulin is an eligible expense. Using pre-tax dollars effectively gives you a discount equal to your tax rate — typically 20-30%.
It may sound unusual, but some pharmacies — especially independents — are willing to negotiate pricing on expensive medications. Ask the pharmacist if they can offer a better cash price, especially if you're paying out of pocket. The worst they can say is no.
Hyperrho is a critical medication that no Rh-negative pregnant woman should have to go without because of cost. Between insurance coverage, patient assistance programs, in-office administration, and brand flexibility, there are real strategies to make it affordable.
Start by understanding how your insurance covers it (medical vs. pharmacy benefit), explore patient assistance programs if you're uninsured, and don't be afraid to ask your provider and pharmacist about cost-saving options.
For help finding Hyperrho in stock, visit Medfinder. For more information about the medication itself, read our articles on what Hyperrho is and the current shortage update.
You focus on staying healthy. We'll handle the rest.
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