Can't Find Hyperrho? You Have Options

If your pharmacy just told you Hyperrho is out of stock, take a deep breath. You're not out of options. Several other Rho(D) immune globulin products are available that do the exact same thing — and your doctor can help you switch to one of them.

In this article, we'll explain what Hyperrho is, how it works, and walk you through the best alternatives available in 2026.

What Is Hyperrho?

Hyperrho (HyperRHO S/D) is a brand-name Rho(D) immune globulin product manufactured by Grifols. It's a biological medication made from human plasma that contains antibodies against the Rh(D) antigen.

Hyperrho is primarily used to prevent Rh sensitization — a condition where an Rh-negative mother's immune system develops antibodies against Rh-positive fetal blood cells. If left unpreventd, this can lead to hemolytic disease of the fetus and newborn (HDFN), which can be life-threatening for the baby in current or future pregnancies.

Hyperrho is given as an intramuscular (IM) injection, typically at 28 weeks of pregnancy and within 72 hours after delivery. It's also used after miscarriage, ectopic pregnancy, amniocentesis, and other events where fetal-maternal blood mixing may occur.

How Does Hyperrho Work?

When an Rh-negative mother is exposed to Rh-positive fetal blood, her immune system may recognize the Rh(D) antigen as foreign and begin producing antibodies against it. These antibodies can cross the placenta in future pregnancies and attack the baby's red blood cells.

Hyperrho works by flooding the mother's system with pre-made anti-Rh(D) antibodies. These antibodies quickly find and destroy any Rh-positive fetal red blood cells in the mother's bloodstream before her own immune system can react. This prevents her body from ever "learning" to make its own anti-D antibodies.

Think of it like a cleanup crew that arrives before your immune system even notices there's a problem.

Alternatives to Hyperrho

All Rho(D) immune globulin products work the same way — they contain anti-D antibodies derived from human plasma. The differences between brands are mainly in manufacturing, formulation, and route of administration. Here are your options:

1. RhoGAM (Kedrion Biopharma)

RhoGAM is the most widely recognized and commonly used Rho(D) immune globulin product in the United States. In fact, "RhoGAM" has become almost a generic term that many patients and even providers use to refer to any Rho(D) immune globulin product.

• Available as: RhoGAM Ultra-Filtered Plus (Full Dose, 300 mcg) and MICRhoGAM Ultra-Filtered Plus (Mini-Dose, 50 mcg)
• Administration: Intramuscular (IM) injection only
• Indications: Prevention of Rh sensitization during and after pregnancy, after miscarriage or abortion, and after other sensitizing events
• Cost: Approximately $150–$350 per dose, similar to Hyperrho
• Availability: RhoGAM is generally more widely available than Hyperrho because Kedrion Biopharma is one of the larger producers. However, it can also experience shortages during periods of high demand.

RhoGAM is the most common direct substitute for Hyperrho and is functionally interchangeable for all obstetric indications.

2. WinRho SDF (Saol Therapeutics)

WinRho SDF is unique among Rho(D) immune globulin products because it can be administered both intravenously (IV) and intramuscularly (IM).

• Available as: Single-dose vials in various strengths (600 IU, 1500 IU, 2500 IU, 5000 IU, 15000 IU)
• Administration: IV or IM injection
• Indications: Rh immunoprophylaxis AND treatment of immune thrombocytopenic purpura (ITP) in Rh-positive, non-splenectomized patients
• Important note: WinRho SDF carries a boxed warning for the risk of intravascular hemolysis when administered IV for ITP. This warning does not typically apply when used IM for routine Rh immunoprophylaxis.
• Cost: Generally $200–$500+ per dose depending on strength

WinRho SDF is a solid alternative, especially in clinical settings where IV administration may be preferred.

3. Rhophylac (CSL Behring)

Rhophylac is manufactured by CSL Behring, one of the largest plasma-derived therapies companies in the world.

• Available as: Prefilled syringe, 300 mcg (1500 IU)
• Administration: IV or IM injection
• Indications: Prevention of Rh sensitization during and after pregnancy, and management of incompatible Rh transfusions
• Cost: Approximately $200–$400 per dose
• Availability: May be available when other products are not, as CSL Behring has a large global manufacturing footprint

Rhophylac's dual IV/IM capability makes it versatile, and CSL Behring's large production capacity can sometimes mean better availability during shortages.

How to Switch to an Alternative

Switching from Hyperrho to another Rho(D) immune globulin product is straightforward:

1. Talk to your doctor: Let them know Hyperrho is unavailable. They can write a new prescription for an alternative product or note on the existing prescription that substitution is acceptable.
2. Check availability: Use Medfinder to search for any Rho(D) immune globulin product in stock near you.
3. Ask about dosing: The standard dose for Rh immunoprophylaxis is 300 mcg (1500 IU) regardless of brand. Your doctor will confirm the appropriate dose for your situation.
4. Check with your insurance: Most insurance plans cover all FDA-approved Rho(D) immune globulin products for approved indications. However, it's worth confirming that the alternative is covered under your plan.

What About a Generic Version?

There is no true "generic" Rho(D) immune globulin. Because these products are derived from human plasma (they're biologics), they cannot be manufactured as simple generics like a pill. Each product requires its own specialized manufacturing process. This is one reason why prices remain high and supply can be limited across all brands.

Final Thoughts

If you can't find Hyperrho, don't delay your treatment. RhoGAM, WinRho SDF, and Rhophylac are all effective alternatives that contain the same active ingredient and serve the same purpose. The most important thing is that you receive Rho(D) immune globulin on schedule to protect your current and future pregnancies.

Use Medfinder to search for available Rho(D) immune globulin products near you, and work with your doctor to find the best option. For more information, read our Hyperrho shortage update or learn how to find Hyperrho in stock.