How to Save Money on Trulance in 2026: Coupons, Discounts, and Patient Assistance

Let's be direct: Trulance (plecanatide) is expensive. The average retail price for a 30-day supply is approximately $749–$830, putting it among the pricier medications for IBS-C and chronic idiopathic constipation. But there are multiple ways to reduce that cost significantly — sometimes to as little as $25 per month. Here's a complete breakdown of every savings option available in 2026.

Option 1: Salix Pharmaceuticals Savings Card (Best for Insured Patients)

The Trulance Savings Card, offered by Salix Pharmaceuticals, is the single most powerful savings tool for Trulance — if you qualify. Here are the key details:

• Savings: Out-of-pocket cost reduced to as little as $25 per prescription fill
• Eligibility: Must be commercially insured (private insurance). NOT available for Medicare, Medicaid, VA, TRICARE, or other government programs
• Limit: Up to 12 fills per year; maximum savings limits apply
• How to get it: Register at trulance.com/savings or call 1-855-846-2745

Important: The savings card requires that your out-of-pocket expense is at least $25 per fill to use. If your copay is already under $25, you may not see additional benefit. Check with your pharmacist.

Option 2: GoodRx Coupons

GoodRx coupons can reduce the retail price of Trulance to approximately $620 per month at participating pharmacies — about 17% off the average retail price of $749. GoodRx coupons are available to anyone, with or without insurance, and can be presented at the pharmacy counter in place of your insurance card.

Note: You generally cannot combine a GoodRx coupon with your insurance benefit. Compare your insurance copay versus the GoodRx price and use whichever is lower.

Option 3: SingleCare Discount Card

SingleCare's discount card can bring Trulance down to approximately $552 for 30 tablets at select pharmacies — a savings of over $270 off average retail. Like GoodRx, SingleCare is available with or without insurance and can be used at most major pharmacy chains including CVS, Walgreens, Walmart, Rite Aid, and Kroger.

Prices vary by pharmacy location, so it's worth checking the SingleCare website to compare pricing at pharmacies near you before filling.

Option 4: Salix Patient Assistance Program

For patients who are uninsured or underinsured and meet income-based eligibility requirements, Salix Pharmaceuticals operates a patient assistance program (PAP) that can provide Trulance at no cost or significantly reduced cost. Eligibility criteria vary, and the program is subject to change — contact Salix directly at 1-800-321-4576 to inquire.

Third-party patient assistance programs like The Rx Advocates (rxadvocates.org) can also help you navigate the application process for the Salix PAP, usually for a monthly service fee.

Option 5: Switch to Mail-Order for 90-Day Fills

Many insurance plans charge a lower copay per month when you fill a 90-day supply through their mail-order pharmacy. The math often works out to paying 2 months' copay for a 90-day supply. Check with your insurer's pharmacy benefit manager (such as Express Scripts, OptumRx, or CVS Caremark) to see if this option is available to you. You'll typically need a new prescription from your doctor written for a 90-day supply.

Option 6: Compare Prices at Different Pharmacies

Retail prices for brand-name medications like Trulance can vary by $100 or more between pharmacies in the same zip code. Tools like GoodRx, SingleCare, or the RxSpark discount card let you see real-time prices at pharmacies near you. A few minutes of comparison shopping can yield meaningful savings, especially if you're paying cash.

Option 7: Ask About Switching to a Covered Alternative

If cost remains prohibitive despite all these strategies, talk to your doctor about alternatives to Trulance. Generic lubiprostone (the active ingredient in Amitiza) can cost as little as $35–$200 per month and works similarly by increasing intestinal fluid secretion. Your doctor can determine whether an alternative would be appropriate for your situation.

Quick Comparison: Trulance Savings Options

• Retail price (no help): ~$749–$830/month
• With GoodRx coupon: ~$620/month
• With SingleCare coupon: ~$552/month
• With Salix savings card (commercial insurance): As low as $25/month
• With patient assistance program: Potentially $0 for eligible uninsured/underinsured patients

The Bottom Line

Trulance's list price is high, but you don't have to pay it. Commercially insured patients who use the Salix savings card can pay as little as $25 per month. Cash-pay patients can use GoodRx or SingleCare to reduce the price by 17–30%. And if you're struggling to even find the drug at a pharmacy, medfinder can help you locate which pharmacies near you have it in stock.