How to Save Money on Rezdiffra (Resmetirom) in 2026: Coupons, Discounts, and Patient Assistance

Rezdiffra (resmetirom) is not a cheap medication. With a wholesale acquisition cost of approximately $47,400 per year — roughly $3,950 per month — it is one of the more expensive specialty drugs on the market. But here is the reality: most patients do not pay anywhere near the full list price.

Between manufacturer savings programs, commercial insurance coverage, and patient assistance for those who qualify, many patients access Rezdiffra at dramatically reduced cost. This guide breaks down exactly what Rezdiffra costs in 2026 and every legitimate way to lower your out-of-pocket expenses.

What Does Rezdiffra Cost Without Insurance?

Without any insurance or savings programs, here is what Rezdiffra costs as of 2026:

Monthly cost: Approximately $3,950–$4,116 (30-day supply, either 80 mg or 100 mg — same price regardless of strength)

Annual cost: Approximately $47,400/year (the wholesale acquisition cost set by Madrigal Pharmaceuticals)

Generic available: No — there is no generic resmetirom as of 2026, and none expected in the near term.

The Institute for Clinical and Economic Review (ICER) assessed Rezdiffra's price to be within the cost-effectiveness benchmark of $39,600–$50,100 per year, meaning the pricing is considered reasonable relative to its clinical benefit. That said, even a cost-effective drug can be unaffordable at list price. Here is how to reduce your cost.

Option 1: Madrigal Copay Savings Card (Best Option for Commercially Insured Patients)

If you have commercial insurance (coverage through an employer or private plan — not Medicare or Medicaid), the Rezdiffra Copay Savings Card from Madrigal Pharmaceuticals is your most powerful savings tool. Eligible commercially insured patients may pay as little as $0 per month.

Eligibility requirements:

Must have commercial (private) insurance — not Medicare, Medicaid, Medigap, VA, or TRICARE

Insurance must not cover the full cost of Rezdiffra

Must be 18 years or older and reside in the U.S. or its territories

To enroll: visit copay.rezdiffra.com or ask your specialty pharmacy pharmacist or Madrigal Patient Support navigator to enroll you.

Option 2: Madrigal Patient Assistance Program (For Uninsured or Underinsured Patients)

Madrigal Pharmaceuticals offers a Patient Assistance Program (PAP) for patients who do not have insurance or whose insurance does not cover Rezdiffra, and who meet income eligibility requirements. Qualifying patients may receive Rezdiffra at no cost or a significantly reduced cost.

To find out if you qualify and to apply: call Madrigal Patient Support at 877-219-7770 or visit madrigalpharma.com. Your prescriber's office can also initiate the process.

Option 3: Medicare Part D Coverage

Rezdiffra is covered under Medicare Part D as a specialty tier prescription drug. Prior authorization is required. Starting in 2025, the Inflation Reduction Act's $2,000 annual out-of-pocket cap applies to all Part D plans — meaning your maximum annual drug cost is capped at $2,000, regardless of how expensive the medication is.

Before the $2,000 cap is reached, costs vary by plan phase. Some patients may face significant costs in the early months of the year before the cap kicks in. Ask your Medicare plan about the Medicare Prescription Payment Plan — which allows you to spread costs throughout the year rather than paying a lump sum early in the year.

Option 4: GoodRx and Other Discount Cards

GoodRx, SingleCare, and similar discount platforms do not work at specialty pharmacies — and Rezdiffra is only dispensed at specialty pharmacies. While GoodRx may list Rezdiffra pricing information, the discount card itself cannot be used to fill the prescription at a specialty pharmacy.

For commercially insured patients, the Madrigal Copay Savings Card will almost always provide better savings than any third-party discount card. For uninsured patients, the Madrigal Patient Assistance Program is the better route.

Option 5: 90-Day Supply

Some insurance plans and specialty pharmacies offer a lower per-fill cost when you fill a 90-day supply instead of monthly. This can also reduce the number of shipments and administrative touchpoints. Ask your specialty pharmacy whether your plan allows 90-day fills for Rezdiffra and whether there is a cost advantage.

Cost Summary: What Patients Actually Pay in 2026

Commercial insurance + Copay Savings Card: As low as $0/month

Medicare Part D (after $2,000 OOP cap): $0/month (remaining year after cap is met)

Uninsured + Patient Assistance Program (eligible): Possibly $0

Cash price, no programs: ~$3,950–$4,116/month (~$47,400/year)

One More Tool: medfinder

If you're unsure which specialty pharmacy near you carries Rezdiffra, medfinder calls pharmacies on your behalf to find which ones can fill your prescription. This can save you hours of phone calls and help you get started on treatment faster. For more tips, see: How to Find Rezdiffra in Stock Near You.