Prometrium can cost over $1,800 without insurance. Learn how to save with generic Progesterone, discount cards, patient assistance programs, and more.
If you've ever seen the retail price of brand-name Prometrium, you probably did a double-take. At nearly $1,800 to $1,900 for a 90-day supply, it's one of the more expensive hormone medications on the market. And during an ongoing shortage, some patients feel pressured to pay whatever it takes just to get their medication.
The good news? There are real, practical ways to cut the cost of Progesterone capsules significantly — sometimes to under $15 a month. Here's how.
Let's start with the numbers:
The price difference between brand and generic is enormous. Generic micronized Progesterone capsules are rated as therapeutically equivalent to Prometrium by the FDA, so in most cases, there's no medical reason to pay for the brand. For more on what Prometrium is and how the generic compares, see: What is Prometrium?
Prescription discount cards are one of the easiest ways to save on generic Progesterone — and they work even if you have insurance (you'd use them instead of insurance, not with it).
GoodRx is one of the most popular prescription discount platforms. As of early 2026, GoodRx shows prices for generic Progesterone capsules starting at approximately $12 to $20 for a 30-day supply at many pharmacies. Simply search for "Progesterone" on goodrx.com, compare prices at pharmacies near you, and show the coupon to your pharmacist.
SingleCare offers competitive pricing on generic Progesterone, with prices often in the $15 to $30 range for 30 capsules. You can get a free SingleCare card at singlecare.com and use it at most major pharmacies including CVS, Walgreens, and Walmart.
Several other discount card programs may offer savings on Progesterone:
Pro tip: Prices vary significantly between pharmacies, even with the same discount card. Always compare a few locations before filling your prescription. Costco, Walmart, and independent pharmacies often have the lowest prices.
If you're uninsured or underinsured and struggling with costs, patient assistance programs (PAPs) may be able to help:
NeedyMeds (needymeds.org) is a nonprofit that maintains a comprehensive database of patient assistance programs, including those for hormone medications. Search for "Progesterone" to find available resources.
RxAssist (rxassist.org) is another database of patient assistance programs that can help you find cost-reduction options for Progesterone and other medications.
Virtus Pharmaceuticals, the manufacturer of brand-name Prometrium, does not appear to offer a widely advertised patient savings card or copay assistance program as of 2026. However, it's worth calling their patient line at 1-888-848-3593 to ask about any available programs. Since generic Progesterone is widely available and very affordable with discount cards, most patients won't need manufacturer assistance.
This is the single biggest money-saver. Make sure your prescription is written for generic Progesterone (or that your doctor hasn't written "Dispense As Written" for brand-name Prometrium). The generic is FDA-rated as therapeutically equivalent and costs a fraction of the brand.
Don't assume all pharmacies charge the same price. Cash prices for the same generic medication can vary by $50 or more between pharmacies in the same city. Use GoodRx, SingleCare, or Medfinder to compare before you fill.
If your insurance or pharmacy offers 90-day supplies, you'll often save money per capsule compared to filling 30 days at a time. This also reduces the number of times you have to navigate the shortage.
Mail-order pharmacies — both insurance-affiliated and independent — sometimes offer lower prices on generics. Options to consider:
Generic Progesterone capsules are covered by most insurance plans on Tier 1 or Tier 2, meaning you'll typically pay a low copay ($5 to $25). However:
Some states offer pharmaceutical assistance programs for low-income residents. These programs can help cover the cost of generic medications including Progesterone. Contact your state's health department or visit needymeds.org for state-specific program information.
No one should have to skip their Progesterone because of cost. With generic options starting as low as $12 with a discount card, and multiple assistance programs available for those who need extra help, affordable access is within reach for most patients.
Start by making sure you're getting the generic, compare prices across pharmacies, and don't hesitate to use discount cards — they're free and can save you hundreds of dollars. If you're also having trouble finding Prometrium in stock, visit Medfinder to search pharmacy availability near you, or check out our guide on how to find Prometrium in stock.
You focus on staying healthy. We'll handle the rest.
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